LIN-12/Notch Lateral Signaling (WP2223)
Caenorhabditis elegans
Lateral signaling targets and negative regulation of LET-23 signaling. The LIN-12/Notch pathway plays two related roles in vulval development; to prevent adjacent induced vulval precursor cells (VPCs) from both becoming 1° VPCs and to induce VPCs adjacent to the 1°VPC to take a 2° cell fate. See figure 14 in http://www.wormbook.org/chapters/www_vulvaldev/vulvaldev.pdf.
Authors
Karen Yook , Stefan Raats , Kristina Hanspers , and Egon WillighagenActivity
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Cited In
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Organisms
Caenorhabditis elegansCommunities
Annotations
Pathway Ontology
Notch signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| LIN-12 | GeneProduct | ensembl:WBGene00003001 | |
| lst-1 | GeneProduct | ensembl:WBGene00003083 | |
| lst-2 | GeneProduct | ensembl:WBGene00003084 | |
| lst-4 | GeneProduct | ensembl:WBGene00003086 | |
| ark-1 | GeneProduct | ensembl:WBGene00000186 | |
| lip-1 | GeneProduct | ensembl:WBGene00003043 | |
| dpy-23 | GeneProduct | ensembl:WBGene00001082 | |
| lst-3 | GeneProduct | ensembl:WBGene00003085 | |
| LET-23 | GeneProduct | ensembl:WBGene00002299 | |
| LET-60 | GeneProduct | ensembl:WBGene00002335 | |
| MPK-1 | GeneProduct | ensembl:WBGene00003401 | |
| sli-1 | GeneProduct | ensembl:WBGene00004829 | |
| unc-101 | GeneProduct | ensembl:WBGene00006829 | |
| apm-1 | GeneProduct | ensembl:WBGene00000150 | |
| gap-1 | GeneProduct | ensembl:WBGene00001515 |
References
- Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Yoo AS, Bais C, Greenwald I. Science. 2004 Jan 30;303(5658):663–6. PubMed Europe PMC Scholia
- Vulval development. Sternberg PW. WormBook. 2005 Jun 25;1–28. PubMed Europe PMC Scholia