Brain derived neurotrophic factor (WP2148)

Rattus norvegicus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Brain-derived neurotrophic factor (BDNF) is a growth factor found in the central and peripheral nervous systems. BDNF binds to two well-characterized receptors, TrkB and p75 (aka, low-affinity nerve growth factor receptor) to influence neuronal cell survival and differentiation. In the hippocampus, BDNF activity is also implicated in learning and memory.

Authors

David , Daniela Digles , Martina Summer-Kutmon , and Alex Pico

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

brain-derived neurotrophic factor signaling pathway

Participants

Label Type Compact URI Comment
mBDNF GeneProduct ncbigene:24225
proBDNF GeneProduct ncbigene:24225
TrkB GeneProduct ncbigene:25054
tPA GeneProduct ncbigene:25692
PAI-1 GeneProduct ncbigene:24617
Erk2 (MAPK 1) GeneProduct ncbigene:116590
p75 GeneProduct ncbigene:24596
plasminogen GeneProduct ncbigene:85253
MAP2K1 GeneProduct ncbigene:170851
Ras GeneProduct ncbigene:24525
Raf GeneProduct ncbigene:24703
BDNF GeneProduct ncbigene:24225

References

  1. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen S, et al. Science. 2004 Oct 15;306(5695):487–91. PubMed Europe PMC Scholia
  2. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, et al. Nat Neurosci. 2005 Aug;8(8):1069–77. PubMed Europe PMC Scholia
  3. Prenatal stress differentially alters brain-derived neurotrophic factor expression and signaling across rat strains. Neeley EW, Berger R, Koenig JI, Leonard S. Neuroscience. 2011 Jul 28;187:24–35. PubMed Europe PMC Scholia
  4. Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing. Ding Q, Ying Z, Gómez-Pinilla F. Neuroscience. 2011 Sep 29;192:773–80. PubMed Europe PMC Scholia