Serotonin and anxiety-related events (WP2140)
Mus musculus
Stress and anxiety disorders are risk factors for depression and these behaviours are modulated by corticotropin releasing factor (CRFR1) and serotonin (5-HT2R) receptors. (Source: Berg et al "5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms")
Authors
Yves Slenter , Linda Rieswijk , Martina Summer-Kutmon , Kristina Hanspers , and Egon WillighagenActivity
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Cited In
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
disease pathway signaling pathwayCell Type Ontology
neuron cerebral cortex neuronDisease Ontology
anxiety disorderLabel | Type | Compact URI | Comment |
---|---|---|---|
Serotonin | Metabolite | hmdb:HMDB0000259 | |
ketanserin | Metabolite | chebi:6123 | |
Serotonin Receptor Htr2a | GeneProduct | ensembl:ENSMUSG00000034997 | |
Arc | GeneProduct | ensembl:ENSMUSG00000022602 | |
Serotonin Receptor Htr2c | GeneProduct | ensembl:ENSMUSG00000041380 | |
Serotonin Receptor Htr1a | GeneProduct | ensembl:ENSMUSG00000021721 | |
C-Fos | GeneProduct | ensembl:ENSMUSG00000021250 | |
Plek | GeneProduct | ensembl:ENSMUSG00000020120 | |
Ppp3ca | GeneProduct | mgi:MGI:107164 | |
Prkcb1 | GeneProduct | ensembl:ENSMUSG00000052889 | |
Plcd4 | GeneProduct | ensembl:ENSMUSG00000026173 | |
Grin2d | GeneProduct | ensembl:ENSMUSG00000002771 | |
Nlgn1 | GeneProduct | ensembl:ENSMUSG00000063887 | |
Crhr1 | GeneProduct | ensembl:ENSMUSG00000018634 | |
CRF_MOUSE | Protein | uniprot:Q8CIT0 |
References
- 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. Berg KA, Clarke WP, Chen Y, Ebersole BJ, McKay RD, Maayani S. Mol Pharmacol. 1994 May;45(5):826–36. PubMed Europe PMC Scholia
- CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, et al. Nat Neurosci. 2010 May;13(5):622–9. PubMed Europe PMC Scholia
- Enhanced function of prefrontal serotonin 5-HT(2) receptors in a rat model of psychiatric vulnerability. Benekareddy M, Goodfellow NM, Lambe EK, Vaidya VA. J Neurosci. 2010 Sep 8;30(36):12138–50. PubMed Europe PMC Scholia