Hepatocyte growth factor receptor signaling (WP193)

Mus musculus

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Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.

Authors

Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Eric Weitz , and Denise Slenter

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Cell Type Ontology

hepatocyte

Pathway Ontology

Rho/Rac/Cdc42 mediated signaling pathway scatter factor/hepatocyte growth factor signaling pathway

Participants

Label Type Compact URI Comment
Rapgef1 GeneProduct ncbigene:107746
Raf1 GeneProduct ncbigene:110157
Rap1b GeneProduct ncbigene:215449
Src GeneProduct ncbigene:20779
Ptk2 GeneProduct ncbigene:14083
Crk GeneProduct ncbigene:12928
Ptk2b GeneProduct ncbigene:19229
Pxn GeneProduct ncbigene:19303
Gab1 GeneProduct ncbigene:14388
Pten GeneProduct ncbigene:19211
Hgf GeneProduct ncbigene:15234
Map2k2 GeneProduct ncbigene:26396
Rasa1 GeneProduct ncbigene:218397
Map4k1 GeneProduct ncbigene:26411
Met GeneProduct ncbigene:17295
Map2k1 GeneProduct ncbigene:26395
Itga1 GeneProduct ncbigene:109700
Elk1 GeneProduct ncbigene:13712
Rap1a GeneProduct ncbigene:109905
Mapk1 GeneProduct ncbigene:26413
Pak1 GeneProduct ncbigene:18479
Mapk8 GeneProduct ncbigene:26419
Pik3ca GeneProduct ncbigene:18706
Crkl GeneProduct ncbigene:12929
Stat3 GeneProduct ncbigene:20848
Hras1 GeneProduct ncbigene:15461
Sos1 GeneProduct ncbigene:20662 Son of sevenless homolog 1 (Drosophila) (predicted)
Jun GeneProduct ncbigene:16476
Grb2 GeneProduct ncbigene:14784
Itgb1 GeneProduct ncbigene:16412
Dock1 GeneProduct ncbigene:330662 Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
Ptpn11 GeneProduct ncbigene:19247
Mapk3 GeneProduct ncbigene:26417
Fos GeneProduct ncbigene:14281

References

  1. An overview of the c-MET signaling pathway. Organ SL, Tsao MS. Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S7–19. PubMed Europe PMC Scholia