Iron homeostasis (WP1596)
Mus musculus
Iron is nessisary for all mammalian cells but is also toxic in excess. This pathway shows the regulation of iron between a cell and the blood stream.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Martijn Van Iersel , Kristina Hanspers , Samuel Sklar , Egon Willighagen , Daniela Digles , Martina Summer-Kutmon , and Eric WeitzActivity
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Cited In
- Podocyte-specific KLF6 primes proximal tubule CaMK1D signaling to attenuate diabetic kidney disease (2024).
- Astrocyte secretome remodeling under iron deficiency: potential implications for brain iron homeostasis (2025).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
iron homeostasis pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Iron | Metabolite | hmdb:HMDB0000692 | |
| Transferrin | GeneProduct | ensembl:ENSMUSG00000032554 | |
| Fth1 | GeneProduct | ncbigene:14319 | |
| Trfr2 | GeneProduct | ensembl:ENSMUSG00000029716 | |
| Ftl1 | GeneProduct | ensembl:ENSMUSG00000050708 | |
| hepcidin-2 | GeneProduct | ensembl:ENSMUSG00000056978 | |
| Ireb2 | GeneProduct | ensembl:ENSMUSG00000032293 | |
| hepcidin | GeneProduct | ensembl:ENSMUSG00000050440 | |
| Tnf | GeneProduct | ensembl:ENSMUSG00000024401 | |
| IL-6 | GeneProduct | ensembl:ENSMUSG00000025746 | |
| hemojuvelin | GeneProduct | ensembl:ENSMUSG00000038403 | |
| Hfe | GeneProduct | ensembl:ENSMUSG00000006611 | |
| IL6R | GeneProduct | ensembl:ENSMUSG00000027947 | |
| Ferroportin | GeneProduct | ensembl:ENSMUSG00000025993 | |
| IL-1 | GeneProduct | ensembl:ENSMUSG00000027399 |