MAPK signaling pathway (WP1337)

Danio rerio

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Authors

Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

mitogen activated protein kinase signaling pathway mitogen activated protein kinase signaling pathway

Participants

Label Type Compact URI Comment
LPS Metabolite chebi:16412
IP3 Metabolite chebi:16595
Ca2+ Metabolite hmdb:HMDB0000464
cAMP Metabolite hmdb:HMDB0000058
Ca2+ Metabolite hmdb:HMDB0000464
DAG Metabolite chebi:18035
traf6 GeneProduct ensembl:ENSDARG00000028058 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7189
mef2ca GeneProduct ensembl:ENSDARG00000029764 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4208
srfa GeneProduct ensembl:ENSDARG00000053918 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6722
elk4 GeneProduct ensembl:ENSDARG00000077092 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000158711
rap1aa GeneProduct ensembl:ENSDARG00000012553 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5906
crk GeneProduct ensembl:ENSDARG00000055635 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1398
pdgfba GeneProduct ensembl:ENSDARG00000086778 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5155
akt3b GeneProduct ensembl:ENSDARG00000087205 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10000
ecsit GeneProduct ensembl:ENSDARG00000062834 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:51295
MAP3K13 GeneProduct ensembl:ENSDARG00000009493 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9175
rasgrp4 GeneProduct ensembl:ENSDARG00000061796 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:115727
map3k7 GeneProduct ensembl:ENSDARG00000020469 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6885
mapk9 GeneProduct ensembl:ENSDARG00000077364 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5601
grb2a GeneProduct ensembl:ENSDARG00000105276 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2885
mknk1 GeneProduct ensembl:ENSDARG00000018411 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8569
dusp1 GeneProduct ensembl:ENSDARG00000100515 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1843
stmn1a GeneProduct ensembl:ENSDARG00000004169 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3925
elk1 GeneProduct ensembl:ENSDARG00000078066 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2002
egfra GeneProduct ensembl:ENSDARG00000013847 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1956
ppp3cca GeneProduct ensembl:ENSDARG00000014962 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5533
nfatc1 GeneProduct ensembl:ENSDARG00000036168 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4772
arrb2b GeneProduct ensembl:ENSDARG00000011545 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:409
maptb GeneProduct ensembl:ENSDARG00000087616 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4137
rap1b GeneProduct ensembl:ENSDARG00000008867 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5908
ikbkg GeneProduct ensembl:ENSDARG00000017037 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8517
bdnf GeneProduct ensembl:ENSDARG00000018817 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:627
daxx GeneProduct ensembl:ENSDARG00000000729 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1616
mapk10 GeneProduct ensembl:ENSDARG00000102730 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5602
tnfb GeneProduct ensembl:ENSDARG00000013598 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7124
mos GeneProduct ensembl:ENSDARG00000069744 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4342
mapk14a GeneProduct ensembl:ENSDARG00000000857 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1432
ikbkb GeneProduct ensembl:ENSDARG00000079123 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3551
arrb1 GeneProduct ensembl:ENSDARG00000043241 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:408
lrrk2 GeneProduct ensembl:ENSDARG00000006169 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000188906
casp3b GeneProduct ensembl:ENSDARG00000055045 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:836
flna GeneProduct ensembl:ENSDARG00000074201 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2316
prkacab GeneProduct ensembl:ENSDARG00000016809 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5566
mapkapk2a GeneProduct ensembl:ENSDARG00000002552 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9261
tnfrsf1a GeneProduct ensembl:ENSDARG00000018569 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000067182
map3k14a GeneProduct ensembl:ENSDARG00000074060 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000006062
hspb1 GeneProduct ensembl:ENSDARG00000041065 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3315
zak GeneProduct ensembl:ENSDARG00000044615 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:51776
gna12a GeneProduct ensembl:ENSDARG00000025826 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2768
tgfb1a GeneProduct ensembl:ENSDARG00000041502 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7040
map3k1 GeneProduct ensembl:ENSDARG00000098405 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4214
map3k2 GeneProduct ensembl:ENSDARG00000062884 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10746
max GeneProduct ensembl:ENSDARG00000024844 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4149
dusp10 GeneProduct ensembl:ENSDARG00000052465 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:11221
rasgrf2a GeneProduct ensembl:ENSDARG00000075054 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5924
PDGFRB GeneProduct ensembl:ENSDARG00000100897 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5159
tab1 GeneProduct ensembl:ENSDARG00000036613 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10454
map3k4 GeneProduct ensembl:ENSDARG00000104835 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4216
gadd45aa GeneProduct ensembl:ENSDARG00000043581 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1647
map2k5 GeneProduct ensembl:ENSDARG00000011851 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5607
cdc25b GeneProduct ensembl:ENSDARG00000010792 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:994
CU855885.1 GeneProduct ensembl:ENSDARG00000101527 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3554
rac2 GeneProduct ensembl:ENSDARG00000038010 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5880
prkcdb GeneProduct ensembl:ENSDARG00000070651 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5580
ppp5c GeneProduct ensembl:ENSDARG00000034313 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5536
map2k1 GeneProduct ensembl:ENSDARG00000007825 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5604
rac1b GeneProduct ensembl:ENSDARG00000087954 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5879
CABZ01078737.1 GeneProduct ensembl:ENSDARG00000100461 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7850
tab2 GeneProduct ensembl:ENSDARG00000021509 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:23118
tgfbr1a GeneProduct ensembl:ENSDARG00000017494 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7046
mapk1 GeneProduct ensembl:ENSDARG00000027552 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5594
CABZ01062511.1 GeneProduct ensembl:ENSDARG00000105744 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5801
ptpn5 GeneProduct ensembl:ENSDARG00000074866 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:84867
pla2g4f.1 GeneProduct ensembl:ENSDARG00000056535 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000159337
braf GeneProduct ensembl:ENSDARG00000017661 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:673
ntrk1 GeneProduct ensembl:ENSDARG00000004586 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4914
atf2 GeneProduct ensembl:ENSDARG00000023903 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1386
map2k4a GeneProduct ensembl:ENSDARG00000063583 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6416
fosab GeneProduct ensembl:ENSDARG00000031683 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2353
prkcg GeneProduct ensembl:ENSDARG00000004561 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5582
myca GeneProduct ensembl:ENSDARG00000045695 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4609
sos2 GeneProduct ensembl:ENSDARG00000060506 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6655
tgfb2 GeneProduct ensembl:ENSDARG00000027087 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7042
elk1 GeneProduct ensembl:ENSDARG00000078066 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2002
mapk7 GeneProduct ensembl:ENSDARG00000023110 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5598
dusp4 GeneProduct ensembl:ENSDARG00000044688 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1846
cacng3a GeneProduct ensembl:ENSDARG00000058460 Homology Mapping from Homo sapiens to Danio rerio: Original ID = H:CACNG3
hspa8 GeneProduct ensembl:ENSDARG00000068992 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3312
mapk12b GeneProduct ensembl:ENSDARG00000006409 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6300
mapk8ip1a GeneProduct ensembl:ENSDARG00000102229 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000121653
ppm1ab GeneProduct ensembl:ENSDARG00000043250 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5494
il1b GeneProduct ensembl:ENSDARG00000098700 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3553
elk4 GeneProduct ensembl:ENSDARG00000077092 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000158711
unm_sa808 GeneProduct ensembl:ENSDARG00000078378 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7186
mapk13 GeneProduct ensembl:ENSDARG00000058470 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5603
taok1b GeneProduct ensembl:ENSDARG00000098304 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:57551
map2k6 GeneProduct ensembl:ENSDARG00000099184 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5608
dusp8b GeneProduct ensembl:ENSDARG00000039232 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000184545
akt2 GeneProduct ensembl:ENSDARG00000011219 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:208
mapkapk5 GeneProduct ensembl:ENSDARG00000028082 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8550
RASA2 GeneProduct ensembl:ENSDARG00000078775 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5922
dusp7 GeneProduct ensembl:ENSDARG00000101413 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1849
fgfr1b GeneProduct ensembl:ENSDARG00000011190 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2260
tgfb3 GeneProduct ensembl:ENSDARG00000019367 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7043
egf GeneProduct ensembl:ENSDARG00000052739 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1950
ddit3 GeneProduct ensembl:ENSDARG00000059836 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1649
MAP3K6 GeneProduct ensembl:ENSDARG00000104760 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9064
map3k8 GeneProduct ensembl:ENSDARG00000061710 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1326
ngfb GeneProduct ensembl:ENSDARG00000014050 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000134259
crkl GeneProduct ensembl:ENSDARG00000028699 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1399
taok2b GeneProduct ensembl:ENSDARG00000100620 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9344
mapk3 GeneProduct ensembl:ENSDARG00000070573 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5595
mapk8a GeneProduct ensembl:ENSDARG00000031888 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5599
nr4a1 GeneProduct ensembl:ENSDARG00000000796 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3164
PRKCA GeneProduct ensembl:ENSDARG00000099841 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000154229
atf4a GeneProduct ensembl:ENSDARG00000039515 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:468
pdgfab GeneProduct ensembl:ENSDARG00000098578 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000197461
atf4a GeneProduct ensembl:ENSDARG00000039515 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:468
ntrk2b GeneProduct ensembl:ENSDARG00000098511 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000148053
faslg GeneProduct ensembl:ENSDARG00000098913 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:356
PDGFRB GeneProduct ensembl:ENSDARG00000100897 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000113721
ppm1bb GeneProduct ensembl:ENSDARG00000011496 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5495
fgfr2 GeneProduct ensembl:ENSDARG00000058115 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000066468
cdc42l2 GeneProduct ensembl:ENSDARG00000057869 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:998
fgfr3 GeneProduct ensembl:ENSDARG00000004782 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000068078
lamtor3 GeneProduct ensembl:ENSDARG00000057075 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8649
fgfr4 GeneProduct ensembl:ENSDARG00000069105 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000160867
jun GeneProduct ensembl:ENSDARG00000043531 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3725
sos1 GeneProduct ensembl:ENSDARG00000100503 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000115904
jund GeneProduct ensembl:ENSDARG00000067850 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3727
rras GeneProduct ensembl:ENSDARG00000006553 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000126458
hrasa GeneProduct ensembl:ENSDARG00000098497 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000174775
rps6ka5 GeneProduct ensembl:ENSDARG00000060551 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9252
map3k12 GeneProduct ensembl:ENSDARG00000103651 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7786
tp53 GeneProduct ensembl:ENSDARG00000035559 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7157
rras2 GeneProduct ensembl:ENSDARG00000036252 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000133818
nfkb1 GeneProduct ensembl:ENSDARG00000105261 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4790
GNG12 GeneProduct ensembl:ENSDARG00000098123 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000172380
CABZ01068093.1 GeneProduct ensembl:ENSDARG00000101721 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000105499
nf1a GeneProduct ensembl:ENSDARG00000012982 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000196712
rasgrp2 GeneProduct ensembl:ENSDARG00000062328 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000068831
akt1 GeneProduct ensembl:ENSDARG00000099657 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:207
rasgrp3 GeneProduct ensembl:ENSDARG00000077864 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000152689
rasgrp4 GeneProduct ensembl:ENSDARG00000061796 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000171777
rasa1b GeneProduct ensembl:ENSDARG00000073665 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5921
RASGRF1 GeneProduct ensembl:ENSDARG00000073824 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000058335
hsc70 GeneProduct ensembl:ENSDARG00000012381 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000173110
ntf3 GeneProduct ensembl:ENSDARG00000059043 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000185652
rapgef2 GeneProduct ensembl:ENSDARG00000005482 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000109756
prkacba GeneProduct ensembl:ENSDARG00000001782 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000142875
hsc70 GeneProduct ensembl:ENSDARG00000012381 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3303
prkacab GeneProduct ensembl:ENSDARG00000016809 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000165059
stk3 GeneProduct ensembl:ENSDARG00000011312 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6788
dusp3a GeneProduct ensembl:ENSDARG00000061255 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000108861
map4k3b GeneProduct ensembl:ENSDARG00000071357 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8491
chuk GeneProduct ensembl:ENSDARG00000011662 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000213341
tgfbr2b GeneProduct ensembl:ENSDARG00000034541 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7048
nfkb2 GeneProduct ensembl:ENSDARG00000038687 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000077150
map4k6 GeneProduct ensembl:ENSDARG00000033444 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000168067
rela GeneProduct ensembl:ENSDARG00000098696 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000173039
map2k7 GeneProduct ensembl:ENSDARG00000008279 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5609
relb GeneProduct ensembl:ENSDARG00000086173 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000104856
ppp3r1a GeneProduct ensembl:ENSDARG00000092659 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5534
nlk2 GeneProduct ensembl:ENSDARG00000028793 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:51701
dusp2 GeneProduct ensembl:ENSDARG00000098108 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000158050
dusp16 GeneProduct ensembl:ENSDARG00000102474 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000111266
fas GeneProduct ensembl:ENSDARG00000043586 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:355
mknk2b GeneProduct ensembl:ENSDARG00000015164 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000099875
pla2g4aa GeneProduct ensembl:ENSDARG00000024546 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000116711
nfatc3a GeneProduct ensembl:ENSDARG00000076297 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000072736
map3k5 GeneProduct ensembl:ENSDARG00000005416 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4217
MAP3K11 GeneProduct ensembl:ENSDARG00000091521 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4296
taok3b GeneProduct ensembl:ENSDARG00000094052 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000135090
dusp6 GeneProduct ensembl:ENSDARG00000070914 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1848
map2k2a GeneProduct ensembl:ENSDARG00000006609 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5605
mapk11 GeneProduct ensembl:ENSDARG00000045836 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000185386
rps6ka4 GeneProduct ensembl:ENSDARG00000044436 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000162302
mapkapk3 GeneProduct ensembl:ENSDARG00000089016 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000114738
rac3b GeneProduct ensembl:ENSDARG00000020795 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000169750
mapk8ip2 GeneProduct ensembl:ENSDARG00000063157 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000008735
mapk8ip3 GeneProduct ensembl:ENSDARG00000062531 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000138834
flnbl GeneProduct ensembl:ENSDARG00000097351 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000136068
flnca GeneProduct ensembl:ENSDARG00000018566 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000128591
hsc70 GeneProduct ensembl:ENSDARG00000012381 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000204388
hsc70 GeneProduct ensembl:ENSDARG00000012381 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000204390
hsc70 GeneProduct ensembl:ENSDARG00000012381 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000126803
MRAS GeneProduct ensembl:ENSDARG00000075285 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:22808
nras GeneProduct ensembl:ENSDARG00000038225 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4893
raf1a GeneProduct ensembl:ENSDARG00000096415 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5894
pla2g4f.1 GeneProduct ensembl:ENSDARG00000056535 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000243708
pla2g4f.1 GeneProduct ensembl:ENSDARG00000056535 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000188089
cacng2a GeneProduct ensembl:ENSDARG00000032565 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000166862
cacng5b GeneProduct ensembl:ENSDARG00000039240 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000075429
cacng4b GeneProduct ensembl:ENSDARG00000074669 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000075461
CACNA2D3 GeneProduct ensembl:ENSDARG00000106018 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000157445
cacng8a GeneProduct ensembl:ENSDARG00000020450 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000142408
cacng7b GeneProduct ensembl:ENSDARG00000070624 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000105605
cacng6a GeneProduct ensembl:ENSDARG00000036457 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000130433
cacna1aa GeneProduct ensembl:ENSDARG00000037905 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000141837
cacna1bb GeneProduct ensembl:ENSDARG00000079295 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000148408
cacna1c GeneProduct ensembl:ENSDARG00000008398 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000151067
cfap74 GeneProduct ensembl:ENSDARG00000075917 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000157388
cacna1ea GeneProduct ensembl:ENSDARG00000062346 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000198216
cacna1fb GeneProduct ensembl:ENSDARG00000023683 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000102001
cacna1sb GeneProduct ensembl:ENSDARG00000042552 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000081248
cacna2d1a GeneProduct ensembl:ENSDARG00000014804 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000153956
cacnb1 GeneProduct ensembl:ENSDARG00000002167 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000067191
cacnb2a GeneProduct ensembl:ENSDARG00000099045 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000165995
cacnb3b GeneProduct ensembl:ENSDARG00000076030 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000167535
cacnb4a GeneProduct ensembl:ENSDARG00000009738 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000182389
cacng1b GeneProduct ensembl:ENSDARG00000052360 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000108878
cacna1i GeneProduct ensembl:ENSDARG00000070522 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000100346
cacna1ha GeneProduct ensembl:ENSDARG00000060496 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000196557
cacna1g GeneProduct ensembl:ENSDARG00000089913 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000006283
cacna2d2b GeneProduct ensembl:ENSDARG00000078169 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000007402
cacna2d4b GeneProduct ensembl:ENSDARG00000023886 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000151062
fgf4 GeneProduct ensembl:ENSDARG00000105230 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2249
fgf2 GeneProduct ensembl:ENSDARG00000104348 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000138685
fgf3 GeneProduct ensembl:ENSDARG00000101540 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000186895
fgf4 GeneProduct ensembl:ENSDARG00000105230 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000075388
fgf5 GeneProduct ensembl:ENSDARG00000035377 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000138675
fgf6a GeneProduct ensembl:ENSDARG00000009351 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000111241
fgf7 GeneProduct ensembl:ENSDARG00000059387 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000140285
fgf8a GeneProduct ensembl:ENSDARG00000003399 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000107831
fgf10a GeneProduct ensembl:ENSDARG00000030932 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000070193
fgf11b GeneProduct ensembl:ENSDARG00000043907 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000161958
fgf12b GeneProduct ensembl:ENSDARG00000062542 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000114279
fgf13b GeneProduct ensembl:ENSDARG00000056633 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000129682
fgf14 GeneProduct ensembl:ENSDARG00000040982 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000102466
fgf20a GeneProduct ensembl:ENSDARG00000007356 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000078579
fgf21 GeneProduct ensembl:ENSDARG00000100846 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000105550
fgf22 GeneProduct ensembl:ENSDARG00000076510 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000070388
fgf23 GeneProduct ensembl:ENSDARG00000045854 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000118972
fgf18a GeneProduct ensembl:ENSDARG00000088048 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000156427
fgf17 GeneProduct ensembl:ENSDARG00000102778 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000158815
fgf16 GeneProduct ensembl:ENSDARG00000042233 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000196468
fgf19 GeneProduct ensembl:ENSDARG00000098663 Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000162344
pak2a GeneProduct ensembl:ENSDARG00000068177 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5062

References

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  11. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, et al. Cell Death Differ. 2012 Oct;19(10):1623–33. PubMed Europe PMC Scholia