EGFR1 signaling pathway (WP1323)

Danio rerio

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The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: NetPath

For a description of pathway objects, see the WikiPathways Legend.

Authors

Michiel Adriaens , Alex Pico , Christine Chichester , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

epidermal growth factor/neuregulin signaling pathway

Participants

Label Type Compact URI Comment
zgc:77033 GeneProduct ncbigene:406598
wu:fc58a04 GeneProduct ncbigene:325179
LOC562134 GeneProduct ncbigene:562134
cdc42l GeneProduct ncbigene:793158
htt GeneProduct ncbigene:30214
cblb GeneProduct ncbigene:556277
pak1 GeneProduct ncbigene:373103
stxbp1 GeneProduct ncbigene:574003
hat1 GeneProduct ncbigene:447833
crkl GeneProduct ncbigene:556443
jak2b GeneProduct ncbigene:30298
mapk1 GeneProduct ncbigene:360144
LOC792354 GeneProduct ncbigene:792354
mta2 GeneProduct ncbigene:326078
prkcb1 GeneProduct ncbigene:393953
SNRPD2 GeneProduct ncbigene:550244
rbb4l GeneProduct ncbigene:322129
map3k3 GeneProduct ncbigene:560211
pik3r3 GeneProduct ncbigene:100000252
camk2a GeneProduct ncbigene:550436
LOC568935 GeneProduct ncbigene:568935
cbl GeneProduct ncbigene:492364
CH211-67F24.8 GeneProduct ncbigene:561670
wu:fk86g11 GeneProduct ncbigene:559145
KRT18 GeneProduct ncbigene:352912
gab1 GeneProduct ncbigene:406666
FOXO1A GeneProduct ncbigene:768121
wu:fb92a07 GeneProduct ncbigene:100002263
sp1 GeneProduct ncbigene:324109
dnm2 GeneProduct ncbigene:559334
zgc:172209 GeneProduct ncbigene:562720
DDEF1 GeneProduct ncbigene:326709
spry2 GeneProduct ncbigene:335098
egfr GeneProduct ncbigene:378478
LOC563639 GeneProduct ncbigene:563639
plcg1 GeneProduct ncbigene:373867
LOC795505 GeneProduct ncbigene:795505
sh3gl2 GeneProduct ncbigene:394091
tnip1 GeneProduct ncbigene:449958
LOC565173 GeneProduct ncbigene:565173
elf3 GeneProduct ncbigene:560869
ptpn6 GeneProduct ncbigene:335573
LOC558321 GeneProduct ncbigene:558321
zgc:64130 GeneProduct ncbigene:394184
zgc:76867 GeneProduct ncbigene:404612
tgif1 GeneProduct ncbigene:321756
prkcz GeneProduct ncbigene:555737
pld2 GeneProduct ncbigene:565743
STAT2 GeneProduct ncbigene:565200
LOC567895 GeneProduct ncbigene:567895
zgc:175192 GeneProduct ncbigene:568309
jund GeneProduct ncbigene:564873
nras GeneProduct ncbigene:30380
zgc:56041 GeneProduct ncbigene:393212
smad3b GeneProduct ncbigene:326283
rps6ka3b GeneProduct ncbigene:100009657
appl2 GeneProduct ncbigene:100000135
egf GeneProduct ncbigene:403045
LOC793823 GeneProduct ncbigene:793823
grb2 GeneProduct ncbigene:406308
LOC100149498 GeneProduct ncbigene:100149498
LOC100149671 GeneProduct ncbigene:100149671
zgc:162129 GeneProduct ncbigene:798009
EPN1 GeneProduct ncbigene:406671
wu:fc83c01 GeneProduct ncbigene:325488
im:7150469 GeneProduct ncbigene:567938
zgc:92074 GeneProduct ncbigene:403063
src GeneProduct ncbigene:325084
znf259 GeneProduct ncbigene:406382
plcg2 GeneProduct ncbigene:561747
sh2d3ca GeneProduct ncbigene:558860
stat1a GeneProduct ncbigene:30768
casp9 GeneProduct ncbigene:492763
LOC100003514 GeneProduct ncbigene:100003514
jak1 GeneProduct ncbigene:30280
dusp1 GeneProduct ncbigene:406340
si:dkey-217m5.1 GeneProduct ncbigene:564535
rps6ka3a GeneProduct ncbigene:338219
LOC558153 GeneProduct ncbigene:558153
CH211-125M10.3 GeneProduct ncbigene:558144
pik3r2 GeneProduct ncbigene:404211
LOC562032 GeneProduct ncbigene:562032
HRAS GeneProduct ncbigene:550286
zgc:112145 GeneProduct ncbigene:550427
smad2 GeneProduct ncbigene:30639
stat3 GeneProduct ncbigene:30767
pitpna GeneProduct ncbigene:393909
LOC571285 GeneProduct ncbigene:571285
mapk14a GeneProduct ncbigene:65237
kras GeneProduct ncbigene:445289
si:ch211-240l19.1 GeneProduct ncbigene:561159
zgc:172137 GeneProduct ncbigene:100007679
LOC564517 GeneProduct ncbigene:564517
pik3cd GeneProduct ncbigene:394174
fos GeneProduct ncbigene:394198
rac1 GeneProduct ncbigene:327204
LOC559524 GeneProduct ncbigene:559524
zgc:158742 GeneProduct ncbigene:571626
jun GeneProduct ncbigene:335916
rasa1 GeneProduct ncbigene:100002155
mapk3 GeneProduct ncbigene:399480
zgc:172250 GeneProduct ncbigene:100002225
PTPN12 GeneProduct ncbigene:393642
ripk1l GeneProduct ncbigene:567460
LOC571965 GeneProduct ncbigene:571965
raf1 GeneProduct ncbigene:30716
CSK GeneProduct ncbigene:556454
zgc:153534 GeneProduct ncbigene:767738
socs1 GeneProduct ncbigene:445073
creb1 GeneProduct ncbigene:573207
ptpn11 GeneProduct ncbigene:333979
si:ch211-197i12.3 GeneProduct ncbigene:555476
LOC560913 GeneProduct ncbigene:560913
map2k1 GeneProduct ncbigene:406728
CEACAM1 GeneProduct ncbigene:114465
pbp GeneProduct ncbigene:406627
ELK4 GeneProduct ncbigene:30093
RAB5A GeneProduct ncbigene:337737
ptk2bb GeneProduct ncbigene:245950
cav2 GeneProduct ncbigene:415240
LOC100008005 GeneProduct ncbigene:100008005
LOC100151336 GeneProduct ncbigene:100151336
atf1 GeneProduct ncbigene:325609
prkci GeneProduct ncbigene:117507
cx43 GeneProduct ncbigene:30236
hdac1 GeneProduct ncbigene:192302
zgc:92024 GeneProduct ncbigene:445098
LOC564899 GeneProduct ncbigene:564899
LOC557201 GeneProduct ncbigene:557201
LOC100007590 GeneProduct ncbigene:100007590
LOC557176 GeneProduct ncbigene:557176
LOC561737 GeneProduct ncbigene:561737
cebpa GeneProduct ncbigene:140815
LOC556726 GeneProduct ncbigene:556726
ralb GeneProduct ncbigene:445255
cebpb GeneProduct ncbigene:140814
pxn GeneProduct ncbigene:399546
LOC559119 GeneProduct ncbigene:559119
cav1 GeneProduct ncbigene:323695
LOC557123 GeneProduct ncbigene:557123
si:dkeyp-192m14.7 GeneProduct ncbigene:568170
crk GeneProduct ncbigene:445234
zgc:110206 GeneProduct ncbigene:550519
CH211-251J10.3 GeneProduct ncbigene:799483
LOC568321 GeneProduct ncbigene:568321
mapk7 GeneProduct ncbigene:541323
KRT8 GeneProduct ncbigene:797433
wasla GeneProduct ncbigene:100009637

References

  1. Control of MAPK signalling: from complexity to what really matters. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV. Oncogene. 2005 Aug 25;24(36):5533–42. PubMed Europe PMC Scholia