Estrogen metabolism (WP1302)

Rattus norvegicus

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Authors

Kristina Hanspers , Martina Summer-Kutmon , and Susan Coort

Activity

last edited

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

steroid metabolic pathway

Participants

Label Type Compact URI Comment
2-Hydroxyestrone Metabolite hmdb:HMDB0000343
Estrone Metabolite hmdb:HMDB0000145
2-Hydroxyestradiol Metabolite hmdb:HMDB0000338
Estrone sulfate Metabolite hmdb:HMDB0001425
Oxygen Metabolite hmdb:HMDB0001377
Estrone-2,3-quinone Metabolite pubchem.compound:148381
16a-Hydroxyestrone Metabolite hmdb:HMDB0000335
2-Methoxyestrone 3-glucuronide Metabolite hmdb:HMDB0004482
Estradiol-3-glucuronide Metabolite hmdb:HMDB0006224
Superoxide Metabolite hmdb:HMDB0002168
2-Methoxyestradiol Metabolite hmdb:HMDB0000405
Estrone-17-glucuronide Metabolite hmdb:HMDB0004483
4-Methoxyestradiol Metabolite hmdb:HMDB0000405
Estrone-3-glucuronide Metabolite hmdb:HMDB0004483
2-Methoxyestrone Metabolite hmdb:HMDB0000010
Estrone-3,4-quinone Metabolite pubchem.compound:114862
Comt GeneProduct ensembl:ENSRNOG00000001889
Ugt1a3 GeneProduct ensembl:ENSRNOG00000018740
Cyp1a2 GeneProduct ensembl:ENSRNOG00000016173
Ugt1a1 GeneProduct ncbigene:24861
Ste GeneProduct ensembl:ENSRNOG00000001957
Sult1a1 GeneProduct ensembl:ENSRNOG00000019342
Arse GeneProduct ensembl:ENSRNOG00000028350
Nqo1 GeneProduct ensembl:ENSRNOG00000012772
Cyp1a1 GeneProduct ensembl:ENSRNOG00000019500
UGT1A9 GeneProduct ncbigene:396552
Ugt1a2 GeneProduct ncbigene:396527
GSTM1 GeneProduct ncbigene:24423
Sts GeneProduct ncbigene:24800
Cyp1b1 GeneProduct ensembl:ENSRNOG00000040287

References

  1. Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, et al. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10937–42. PubMed Europe PMC Scholia
  2. Estrogen metabolism by conjugation. Raftogianis R, Creveling C, Weinshilboum R, Weisz J. J Natl Cancer Inst Monogr. 2000;(27):113–24. PubMed Europe PMC Scholia
  3. 2-Methoxyestradiol, a promising anticancer agent. Lakhani NJ, Sarkar MA, Venitz J, Figg WD. Pharmacotherapy. 2003 Feb;23(2):165–72. PubMed Europe PMC Scholia
  4. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM. Mol Endocrinol. 2003 Jul;17(7):1344–55. PubMed Europe PMC Scholia
  5. Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, et al. Carcinogenesis. 2003 Apr;24(4):697–702. PubMed Europe PMC Scholia
  6. Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Guillemette C, Bélanger A, Lépine J. Breast Cancer Res. 2004;6(6):246–54. PubMed Europe PMC Scholia
  7. Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases. Abel EL, Lyon RP, Bammler TK, Verlinde CLMJ, Lau SS, Monks TJ, et al. Chem Biol Interact. 2004 Dec 30;151(1):21–32. PubMed Europe PMC Scholia
  8. Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL. Breast Cancer Res. 2005;7(6):R909-21. PubMed Europe PMC Scholia