DNA replication (WP13)

Saccharomyces cerevisiae

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DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia] Based on www.genomeknowledge.org

Authors

Kdahlquist , David Koren , Thomas Kelder , Christine Chichester , Egon Willighagen , Kristina Hanspers , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

DNA replication pathway

Participants

Label Type Compact URI Comment
GTP Metabolite cas:2564-35-4
ATP Metabolite cas:1927-31-7
dCTP Metabolite cas:2056-98-6
dGTP Metabolite cas:2564-35-4
dATP Metabolite cas:1927-31-7
ADP Metabolite cas:58-64-0
RFA2 GeneProduct ncbigene:855404
POL1 GeneProduct ncbigene:855621
PRI1 GeneProduct ncbigene:854825
PRI2 GeneProduct ncbigene:853821
DPB2 GeneProduct ncbigene:856305
POL2 GeneProduct ncbigene:855459
ORC2 GeneProduct ncbigene:852352
RPL40A GeneProduct ncbigene:854658
MCM6 GeneProduct ncbigene:852673
CDC46 GeneProduct ncbigene:850980
CDC54 GeneProduct ncbigene:856130
MCM3 GeneProduct ncbigene:856680
MCM2 GeneProduct ncbigene:852258
CDC47 GeneProduct ncbigene:852501
MCM10 GeneProduct ncbigene:854656
POL12 GeneProduct ncbigene:852245
RFC3 GeneProduct ncbigene:855426
RFC2 GeneProduct ncbigene:853531
RFC5 GeneProduct ncbigene:852383
RFC4 GeneProduct ncbigene:854059
RFC1 GeneProduct ncbigene:854392
POL30 GeneProduct ncbigene:852385
CDC7 GeneProduct ncbigene:851545
RFA1 GeneProduct ncbigene:851266
CDC45 GeneProduct ncbigene:850793
HYS2 GeneProduct ncbigene:853462
CDC2 GeneProduct ncbigene:851456
CDC6 GeneProduct ncbigene:853244
UBI4 GeneProduct ncbigene:850620
CDT1 Protein uniprot:P47112

References

  1. A yeast chromosomal origin of DNA replication defined by multiple functional elements. Marahrens Y, Stillman B. Science. 1992 Feb 14;255(5046):817–23. PubMed Europe PMC Scholia
  2. Regulation of chromosome replication. Kelly TJ, Brown GW. Annu Rev Biochem. 2000;69:829–80. PubMed Europe PMC Scholia
  3. DNA replication in eukaryotic cells. Bell SP, Dutta A. Annu Rev Biochem. 2002;71:333–74. PubMed Europe PMC Scholia