EPO receptor signaling (WP1284)

Rattus norvegicus

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The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.

Authors

Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

erythropoietin signaling pathway

Participants

Label Type Compact URI Comment
Epor GeneProduct ncbigene:24336
Jak2 GeneProduct ncbigene:24514
Src GeneProduct ncbigene:83805
Stat1 GeneProduct ncbigene:25124
Shc1 GeneProduct ncbigene:85385
Grb2 GeneProduct ncbigene:81504
Map2k1 GeneProduct ncbigene:170851
Mapk3 GeneProduct ncbigene:50689
Mapk1 GeneProduct ncbigene:116590
Map2k2 GeneProduct ncbigene:58960
Pdk1 GeneProduct ncbigene:116551
Akt1 GeneProduct ncbigene:24185
Pik3cg GeneProduct ensembl:ENSRNOG00000009385
Epo GeneProduct ncbigene:24335
Socs1 GeneProduct ncbigene:252971
Stat5b GeneProduct ncbigene:25126
Cish GeneProduct ncbigene:83681
Stat5a GeneProduct ncbigene:24918
Stat3 GeneProduct ncbigene:25125
Ptprc GeneProduct ncbigene:24699
Ptpru GeneProduct ncbigene:116680
Raf1 GeneProduct ncbigene:24703
Sos1 GeneProduct ncbigene:313845
Irs2 GeneProduct ncbigene:29376
Irs1 GeneProduct ncbigene:25467
Rasa1 GeneProduct ncbigene:25676

References

  1. The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
  2. The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia