G1 to S cell cycle control (WP1195)

Canis familiaris

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In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Authors

Kristina Hanspers , Christine Chichester , and Martina Summer-Kutmon

Activity

last edited pathway curation

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Cited In

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Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

G1/S DNA damage checkpoint pathway cell cycle checkpoint pathway

Participants

Label Type Compact URI Comment
RB1 GeneProduct ensembl:ENSCAFG00000004436 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5925
E2F2 GeneProduct ensembl:ENSCAFG00000013273 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1870
E2F1 GeneProduct ensembl:ENSCAFG00000007435 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1869
POLE GeneProduct ensembl:ENSCAFG00000006215 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5426
CDKN1B GeneProduct ensembl:ENSCAFG00000013244 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1027
CDK6 GeneProduct ensembl:ENSCAFG00000001998 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1021
PCNA GeneProduct ensembl:ENSCAFG00000006030 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5111
CDK4 GeneProduct ensembl:ENSCAFG00000000280 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1019
CDKN1A GeneProduct ensembl:ENSCAFG00000029853 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1026
CDC45 GeneProduct ensembl:ENSCAFG00000014571 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8318
CDK1 GeneProduct ensembl:ENSCAFG00000012904 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:983
TP53 GeneProduct ensembl:ENSCAFG00000016714 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7157
PRIM2 GeneProduct ensembl:ENSCAFG00000023267 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5558
CCND2 GeneProduct ensembl:ENSCAFG00000015381 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:894
E2F5 GeneProduct ensembl:ENSCAFG00000008628 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1875
CCNE1 GeneProduct ensembl:ENSCAFG00000007614 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:898
CREB3L4 GeneProduct ensembl:ENSCAFG00000017395 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:148327
CDKN2B GeneProduct ensembl:ENSCAFG00000001680 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1030
MDM2 GeneProduct ensembl:ENSCAFG00000000418 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4193
CDK7 GeneProduct ensembl:ENSCAFG00000007748 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1022
CCNG2 GeneProduct ensembl:ENSCAFG00000008685 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:901
RPA2 GeneProduct ensembl:ENSCAFG00000011979 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6118
CDK2 GeneProduct ensembl:ENSCAFG00000000082 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1017
E2F4 GeneProduct ensembl:ENSCAFG00000020375 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1874
CREB3 GeneProduct ensembl:ENSCAFG00000002203 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10488
CREB3L3 GeneProduct ensembl:ENSCAFG00000019126 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:84699
MYT1 GeneProduct ensembl:ENSCAFG00000013222 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4661
TFDP2 GeneProduct ensembl:ENSCAFG00000007742 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7029
CCNB1 GeneProduct ensembl:ENSCAFG00000009965 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:891
CCND3 GeneProduct ensembl:ENSCAFG00000001618 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:896
CCND1 GeneProduct ensembl:ENSCAFG00000010700 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:595
CCNH GeneProduct ensembl:ENSCAFG00000008374 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:902
MYC GeneProduct ensembl:ENSCAFG00000001086 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4609
RPA3 GeneProduct ensembl:ENSCAFG00000000261 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6119
MCM4 GeneProduct ensembl:ENSCAFG00000006598 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4173
MCM3 GeneProduct ensembl:ENSCAFG00000002196 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4172
ATF6B GeneProduct ensembl:ENSCAFG00000000761 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1388
ORC1 GeneProduct ensembl:ENSCAFG00000003744 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4998
MCM6 GeneProduct ensembl:ENSCAFG00000005143 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4175
MCM7 GeneProduct ensembl:ENSCAFG00000014748 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4176
MCM2 GeneProduct ensembl:ENSCAFG00000004052 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4171
ORC3 GeneProduct ensembl:ENSCAFG00000003080 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23595
CDKN2C GeneProduct ensembl:ENSCAFG00000028905 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1031
MNAT1 GeneProduct ensembl:ENSCAFG00000015639 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4331
ORC6 GeneProduct ensembl:ENSCAFG00000003683 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23594
MCM5 GeneProduct ensembl:ENSCAFG00000001709 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4174
E2F6 GeneProduct ensembl:ENSCAFG00000023799 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1876
ORC2 GeneProduct ensembl:ENSCAFG00000012060 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4999
E2F3 GeneProduct ensembl:ENSCAFG00000031036 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1871
TFDP1 GeneProduct ensembl:ENSCAFG00000006384 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7027
RPA1 GeneProduct ensembl:ENSCAFG00000019249 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6117
CREB1 GeneProduct ensembl:ENSCAFG00000013510 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1385
RBL1 GeneProduct ensembl:ENSCAFG00000008696 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5933
WEE1 GeneProduct ensembl:ENSCAFG00000007416 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7465
ATM GeneProduct ensembl:ENSCAFG00000014454 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:472
CREB3L1 GeneProduct ensembl:ENSCAFG00000009282 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:90993
GADD45A GeneProduct ensembl:ENSCAFG00000029474 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1647
POLA2 GeneProduct ensembl:ENSCAFG00000013677 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23649
ORC4 GeneProduct ensembl:ENSCAFG00000005522 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5000
PRIM1 GeneProduct ensembl:ENSCAFG00000000142 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5557
CDC25A GeneProduct ensembl:ENSCAFG00000012919 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:993
CCNA1 GeneProduct ensembl:ENSCAFG00000006189 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8900
ORC5 GeneProduct ensembl:ENSCAFG00000004146 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5001
CCNE2 GeneProduct ensembl:ENSCAFG00000009408 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9134

References

  1. GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia