Calcium regulation in cardiac cells (WP1159)

Canis familiaris

Calcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular compartment to the intracellular compartment alters membrane depolarisation. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarisation of the heart. Source: [[wikipedia:Calcium_signaling|Wikipedia]]

Authors

Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Canis familiaris

Communities

Annotations

Disease Ontology

cardiovascular system disease

Pathway Ontology

calcium/calcium-mediated signaling pathway

Cell Type Ontology

cardiac muscle cell

Participants

Label Type Compact URI Comment
ATP Metabolite cas:1927-31-7
Epinephrine Metabolite hmdb:HMDB0000068
Na+ Metabolite hmdb:HMDB0000588
Acetylcholine Metabolite cas:51-84-3
Pi Metabolite hmdb:HMDB0001429
IP4 Metabolite chebi:16783
IP3 Metabolite chemspider:388562
ADP Metabolite cas:58-64-0
K+ Metabolite hmdb:HMDB0000586
Ca2+ Metabolite hmdb:HMDB0000464
cAMP Metabolite pubchem.compound:6076
PIP2 Metabolite hmdb:HMDB0010032
ADP Metabolite hmdb:HMDB0001341
CACNB1 GeneProduct ensembl:ENSCAFG00000016510 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:782
CALM1 GeneProduct ensembl:ENSCAFG00000017563 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:801
CAMK2G GeneProduct ensembl:ENSCAFG00000015161 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:818
RYR2 GeneProduct ensembl:ENSCAFG00000010034 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6262
RGS6 GeneProduct ensembl:ENSCAFG00000016763 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9628
ADCY4 GeneProduct ensembl:ENSCAFG00000012293 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:196883
GNG2 GeneProduct ensembl:ENSCAFG00000031640 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:54331
ADCY1 GeneProduct ensembl:ENSCAFG00000012249 CYA1 HUMAN
Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:107
CAMK2A GeneProduct ensembl:ENSCAFG00000018163 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:815
PRKCB GeneProduct ensembl:ENSCAFG00000017622 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5579
CACNA1E GeneProduct ensembl:ENSCAFG00000013004 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:777
GNG13 GeneProduct ensembl:ENSCAFG00000019608 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51764
RGS1 GeneProduct ensembl:ENSCAFG00000010603 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5996
ATP2B1 GeneProduct ensembl:ENSCAFG00000006121 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:490
PRKACA GeneProduct ensembl:ENSCAFG00000016488 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5566
GNAI2 GeneProduct ensembl:ENSCAFG00000010740 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2771
ATP2A3 GeneProduct ensembl:ENSCAFG00000013971 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:489
ATP2B3 GeneProduct ensembl:ENSCAFG00000019230 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:492
GJA5 GeneProduct ensembl:ENSCAFG00000011069 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2702
PLCB3 GeneProduct ensembl:ENSCAFG00000014542 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5331
ADRA1A GeneProduct ensembl:ENSCAFG00000008725 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:148
GNB4 GeneProduct ensembl:ENSCAFG00000011335 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:59345
PLN GeneProduct ensembl:ENSCAFG00000029347 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5350
RGS20 GeneProduct ensembl:ENSCAFG00000006955 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8601
GJA9 GeneProduct ensembl:ENSCAFG00000024932 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:81025
PRKACB GeneProduct ensembl:ENSCAFG00000020319 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5567
RYR1 GeneProduct ensembl:ENSCAFG00000005896 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6261
CAMK4 GeneProduct ensembl:ENSCAFG00000007379 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:814
ADCY5 GeneProduct ensembl:ENSCAFG00000012084 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:111
PKIB GeneProduct ensembl:ENSCAFG00000029950 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5570
ARRB2 GeneProduct ensembl:ENSCAFG00000015905 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:409
RGS10 GeneProduct ensembl:ENSCAFG00000031204 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6001
ADRA1D GeneProduct ensembl:ENSCAFG00000006068 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:146
ADRB1 GeneProduct ensembl:ENSCAFG00000011219 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:153
RGS14 GeneProduct ensembl:ENSCAFG00000016425 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10636
CACNA1S GeneProduct ensembl:ENSCAFG00000010884 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:779
CHRM4 GeneProduct ensembl:ENSCAFG00000009203 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1132
CHRM2 GeneProduct ensembl:ENSCAFG00000003363 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1129
CACNA1C GeneProduct ensembl:ENSCAFG00000016051 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:775
GJC1 GeneProduct ensembl:ENSCAFG00000014089 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10052
KCNB1 GeneProduct ensembl:ENSCAFG00000011366 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3745
ADCY2 GeneProduct ensembl:ENSCAFG00000010238 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:108
GJA1 GeneProduct ensembl:ENSCAFG00000000958 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2697
ITPR2 GeneProduct ensembl:ENSCAFG00000011345 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3709
PRKAR1B GeneProduct ensembl:ENSCAFG00000011233 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5575
CACNA1D GeneProduct ensembl:ENSCAFG00000008525 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:776
CAMK2D GeneProduct ensembl:ENSCAFG00000032335 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:817
GNB3 GeneProduct ensembl:ENSCAFG00000014655 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2784
CACNA1A GeneProduct ensembl:ENSCAFG00000016897 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:773
KCNJ3 GeneProduct ensembl:ENSCAFG00000009183 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3760
RGS5 GeneProduct ensembl:ENSCAFG00000013250 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8490
YWHAB GeneProduct ensembl:ENSCAFG00000009514 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7529
GNB5 GeneProduct ensembl:ENSCAFG00000015662 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10681
KCNJ5 GeneProduct ensembl:ENSCAFG00000010255 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3762
YWHAZ GeneProduct ensembl:ENSCAFG00000007972 PMID: 9861170 PMID: 1317796
Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7534
YWHAH GeneProduct ensembl:ENSCAFG00000031015 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7533
GJA3 GeneProduct ensembl:ENSCAFG00000007321 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2700
ITPR1 GeneProduct ensembl:ENSCAFG00000023463 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3708
ATP2B2 GeneProduct ensembl:ENSCAFG00000005076 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:491
GJB3 GeneProduct ensembl:ENSCAFG00000003606 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2707
GJB4 GeneProduct ensembl:ENSCAFG00000003609 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:127534
SFN GeneProduct ensembl:ENSCAFG00000012290 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2810
PRKD1 GeneProduct ensembl:ENSCAFG00000012553 KPCM HUMAN
Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5587
GNG12 GeneProduct ensembl:ENSCAFG00000028654 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:55970
GNAQ GeneProduct ensembl:ENSCAFG00000001579 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2776
GNG11 GeneProduct ensembl:ENSCAFG00000002046 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2791
PRKCD GeneProduct ensembl:ENSCAFG00000008689 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5580
GNG7 GeneProduct ensembl:ENSCAFG00000019385 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2788
GJB6 GeneProduct ensembl:ENSCAFG00000007316 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10804
GNAI3 GeneProduct ensembl:ENSCAFG00000019825 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2773
PRKCE GeneProduct ensembl:ENSCAFG00000002610 This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5581
RGS18 GeneProduct ensembl:ENSCAFG00000032530 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:64407
RGS7 GeneProduct ensembl:ENSCAFG00000015679 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6000
GRK5 GeneProduct ensembl:ENSCAFG00000012129 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2869
GNG8 GeneProduct ensembl:ENSCAFG00000004275 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:94235
PKIA GeneProduct ensembl:ENSCAFG00000008350 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5569
RYR3 GeneProduct ensembl:ENSCAFG00000008056 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6263
ITPR3 GeneProduct ensembl:ENSCAFG00000001130 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3710
ADCY8 GeneProduct ensembl:ENSCAFG00000001097 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:114
CHRM1 GeneProduct ensembl:ENSCAFG00000015467 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1128
RGS19 GeneProduct ensembl:ENSCAFG00000030747 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10287
ADRA1B GeneProduct ensembl:ENSCAFG00000017281 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:147
FKBP1A GeneProduct ensembl:ENSCAFG00000023724 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2280
GJB1 GeneProduct ensembl:ENSCAFG00000017023 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2705
GJA8 GeneProduct ensembl:ENSCAFG00000011071 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2703
RGS17 GeneProduct ensembl:ENSCAFG00000000550 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:26575
CASQ1 GeneProduct ensembl:ENSCAFG00000012470 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:844
ADCY3 GeneProduct ensembl:ENSCAFG00000004090 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:109
ANXA6 GeneProduct ensembl:ENSCAFG00000017943 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:309
GNG5 GeneProduct ensembl:ENSCAFG00000001230 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2787
ADCY9 GeneProduct ensembl:ENSCAFG00000019237 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:115
RGS16 GeneProduct ensembl:ENSCAFG00000030416 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6004
SLC8A1 GeneProduct ensembl:ENSCAFG00000023592 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6546
YWHAQ GeneProduct ensembl:ENSCAFG00000003386 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10971
ADCY7 GeneProduct ensembl:ENSCAFG00000009913 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:113
GNAZ GeneProduct ensembl:ENSCAFG00000013663 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2781
ADRB3 GeneProduct ensembl:ENSCAFG00000006161 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:155
GJB5 GeneProduct ensembl:ENSCAFG00000003612 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2709
CALR GeneProduct ensembl:ENSCAFG00000017093 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:811
RGS11 GeneProduct ensembl:ENSCAFG00000023874 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8786
GNGT1 GeneProduct ensembl:ENSCAFG00000002044 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2792
PRKCZ GeneProduct ensembl:ENSCAFG00000019381 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5590
PRKAR1A GeneProduct ensembl:ENSCAFG00000010999 KAP0 HUMAN
Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5573
GNB2 GeneProduct ensembl:ENSCAFG00000014282 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2783
PKIG GeneProduct ensembl:ENSCAFG00000009480 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11142
RGS4 GeneProduct ensembl:ENSCAFG00000029969 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5999
PRKCH GeneProduct ensembl:ENSCAFG00000015695 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5583
PRKAR2B GeneProduct ensembl:ENSCAFG00000003952 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5577
PRKCQ GeneProduct ensembl:ENSCAFG00000005169 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5588
GNG3 GeneProduct ensembl:ENSCAFG00000014643 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2785
PRKCA GeneProduct ensembl:ENSCAFG00000011326 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5578
GNB1 GeneProduct ensembl:ENSCAFG00000019216 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2782
CASQ2 GeneProduct ensembl:ENSCAFG00000009765 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:845
GNAO1 GeneProduct ensembl:ENSCAFG00000009233 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2775
SLC8A3 GeneProduct ensembl:ENSCAFG00000023919 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6547
PLN GeneProduct ensembl:ENSCAFG00000029347 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000198523
ATP2A2 GeneProduct ensembl:ENSCAFG00000008434 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:488
RGS2 GeneProduct ensembl:ENSCAFG00000010595 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5997
ARRB1 GeneProduct ensembl:ENSCAFG00000005415 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:408
GNAS GeneProduct ensembl:ENSCAFG00000023756 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2778
GJB2 GeneProduct ensembl:ENSCAFG00000029537 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2706
CACNA1B GeneProduct ensembl:ENSCAFG00000019380 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:774
GNAI1 GeneProduct ensembl:ENSCAFG00000016413 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2770
CHRM3 GeneProduct ensembl:ENSCAFG00000009967 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1131
RGS9 GeneProduct ensembl:ENSCAFG00000011148 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8787
CHRM5 GeneProduct ensembl:ENSCAFG00000008002 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1133
GJA4 GeneProduct ensembl:ENSCAFG00000003605 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2701
GNG4 GeneProduct ensembl:ENSCAFG00000031630 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2786
YWHAG GeneProduct ensembl:ENSCAFG00000013549 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7532
CAMK1 GeneProduct ensembl:ENSCAFG00000005331 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8536
CACNB3 GeneProduct ensembl:ENSCAFG00000008857 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:784
PRKCG GeneProduct ensembl:ENSCAFG00000002713 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5582
ADCY6 GeneProduct ensembl:ENSCAFG00000008907 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:112
GRK4 GeneProduct ensembl:ENSCAFG00000014693 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2868
PRKAR2A GeneProduct ensembl:ENSCAFG00000012108 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5576
ADRB2 GeneProduct ensembl:ENSCAFG00000018339 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:154
RGS3 GeneProduct ensembl:ENSCAFG00000003267 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5998
GJD2 GeneProduct ensembl:ENSCAFG00000008244 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:57369
GRK6 GeneProduct ensembl:ENSCAFG00000016388 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2870
ATP1A4 GeneProduct ensembl:ENSCAFG00000025205 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:480
ATP1B1 GeneProduct ensembl:ENSCAFG00000015258 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:481
FXYD2 GeneProduct ensembl:ENSCAFG00000012859 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:486
ATP1B2 GeneProduct ensembl:ENSCAFG00000016703 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:482
ATP1B3 GeneProduct ensembl:ENSCAFG00000007731 Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:483

References

  1. Calcium and the heart: a question of life and death. Marks AR. J Clin Invest. 2003 Mar;111(5):597–600. PubMed Europe PMC Scholia