Folate metabolism (WP1075)
Bos taurus
The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.
Authors
Kristina Hanspers , Egon Willighagen , Martina Summer-Kutmon , and Eric WeitzActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
folate metabolic pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
PGE1 | Metabolite | hmdb:HMDB0001442 | Prostaglandin E1 |
F2-Isoprostane | Metabolite | wikidata:Q33659470 | |
8-Isoprostaglandin F2a | Metabolite | hmdb:HMDB0005083 | |
PGE2 | Metabolite | hmdb:HMDB0001220 | Prostaglandin E2 |
Thromboxane B2 | Metabolite | hmdb:HMDB0003252 | |
Thromboxane A2 | Metabolite | hmdb:HMDB0001452 | |
PGF2a | Metabolite | hmdb:HMDB0001139 | Prostaglandin F2a |
NADP+ | Metabolite | hmdb:HMDB0000217 | Nicotinamide adenine dinucleotide phosphate-Oxidized |
Cysteine | Metabolite | hmdb:HMDB0000574 | |
H2O2 | Metabolite | hmdb:HMDB0003125 | Hydrogen peroxide |
5,10-Methylene-THF | Metabolite | hmdb:HMDB0001533 | 5,10-Methylenetetrahydrofolate |
5,10-Methenyl-THF | Metabolite | hmdb:HMDB0001354 | 5,10-Methenyltetrahydrofolic acid |
5-Formyl-THF | Metabolite | hmdb:HMDB0001562 | 5-Formyltetrahydrofolate |
10-Formyl-THF | Metabolite | hmdb:HMDB0000972 | 10-formyltetrahydrofolate |
GAR | Metabolite | hmdb:HMDB0002022 | glycinamide ribonucleotide |
FGAR | Metabolite | chebi:18272 | formylglycinamide ribonucleotide |
Dihydrofolate | Metabolite | hmdb:HMDB0001056 | |
5-methyl-THF | Metabolite | hmdb:HMDB0001396 | 5-methyltetrahydrofolatePredominant food folate |
Folate | Metabolite | chebi:37445 | Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid). |
H2O | Metabolite | hmdb:HMDB0002111 | Glutathione disulfide |
Heme | Metabolite | hmdb:HMDB0003178 | |
THF | Metabolite | hmdb:HMDB0001846 | Tetrahydrofolic acid |
NADPH | Metabolite | hmdb:HMDB0000221 | Nicotinamide adenine dinucleotide phosphate-Reduced |
Manganese | Metabolite | hmdb:HMDB0001333 | |
Folic acid | Metabolite | hmdb:HMDB0000121 | Synthetic folate |
RNS | Metabolite | chebi:62764 | reactive nitrogen specieshttp://en.wikipedia.org/wiki/Reactive_nitrogen_species |
Homocysteine | Metabolite | hmdb:HMDB0000742 | |
Pyridoxal 5'-phosphate | Metabolite | hmdb:HMDB0001491 | |
Pyridoxal 5'-phosphate | Metabolite | hmdb:HMDB0001491 | Vitamin B6 |
Glycine | Metabolite | hmdb:HMDB0000123 | |
L-Arginine | Metabolite | hmdb:HMDB0000517 | |
Serine | Metabolite | hmdb:HMDB0000187 | |
LDL | Metabolite | chebi:39026 | low-density lipoprotein |
HDL/APOA1 | Metabolite | chebi:39025 | high-density lipoproteinApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles |
TAG | Metabolite | chebi:17855 | TriglycerideTriacylglycerol |
Cholesterol | Metabolite | hmdb:HMDB0000067 | |
HDL/SAA | Metabolite | chebi:39025 | high-density lipoproteinSAA circulates in plasma as a constituent of high density lipoproteins (HDL). |
HDL | Metabolite | chebi:39025 | high-density lipoprotein |
oxLDL | Metabolite | chebi:60151 | oxidized low-density lipoprotein |
VLDL | Metabolite | chebi:39027 | very-low-density lipoprotein |
FMN | Metabolite | hmdb:HMDB0001520 | Flavin Mononucleotide |
HDL-C | Metabolite | chebi:47775 | high-density lipoprotein cholesterolCholesterol transport |
VLDL-TAG | Metabolite | chebi:47776 | very-low-density lipoprotein-triglycerideTriglyceride transport |
VLDL/APOB | Metabolite | chebi:39027 | very-low-density lipoproteinThe VLDL is produced in the liver, contains one molecule of apoB100 |
O2 | Metabolite | hmdb:HMDB0001377 | |
Cob(I)alamin | Metabolite | hmdb:HMDB0002174 | Reduced cobalamin |
FAD | Metabolite | hmdb:HMDB0001248 | Flavin adenine dinucleotide |
8-OHdG | Metabolite | hmdb:HMDB0003333 | 8-Hydroxy-deoxyguanosine |
Cob(II)alamin | Metabolite | hmdb:HMDB0002174 | oxidized cobalamin |
ADP | Metabolite | hmdb:HMDB0001341 | Adenosine diphosphate |
Magnesium | Metabolite | hmdb:HMDB0000547 | |
Chlorine | Metabolite | hmdb:HMDB0000492 | |
S-nitrosohomocysteine | Metabolite | pubchem.compound:3035701 | |
Cystathionine | Metabolite | hmdb:HMDB0000099 | |
ATP | Metabolite | hmdb:HMDB0000538 | Adenosine triphosphate |
Zinc | Metabolite | hmdb:HMDB0015532 | |
NO | Metabolite | hmdb:HMDB0003378 | Nitric oxide |
HOCl | Metabolite | hmdb:HMDB0001050 | Hypochlorite |
O3 | Metabolite | chebi:25812 | ozone |
NO2 | Metabolite | chebi:33101 | Nitrogen dioxide |
HNO2 | Metabolite | chebi:25567 | Nitrous acid |
Riboflavin | Metabolite | hmdb:HMDB0000244 | |
O2 | Metabolite | hmdb:HMDB0002168 | Superoxide |
S-Adenosylmethionine | Metabolite | hmdb:HMDB0001185 | |
Methionine | Metabolite | hmdb:HMDB0000696 | |
S-Adenosylhomocysteine | Metabolite | hmdb:HMDB0000939 | |
ONOO/ONOOH | Metabolite | hmdb:HMDB0002179 | Peroxynitrite |
Nitrotyrosine | Metabolite | hmdb:HMDB0001904 | |
Tetrahydrobiopterin | Metabolite | hmdb:HMDB0000027 | H4B |
Glucose | Metabolite | hmdb:HMDB0000122 | |
Fructosamine | Metabolite | hmdb:HMDB0002030 | |
Iron | Metabolite | hmdb:HMDB0000692 | |
NFKB1 | GeneProduct | ensembl:ENSBTAG00000020270 | nuclear factor NF-kappa-B p50 subunitHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:4790 |
FOLR1 | GeneProduct | ensembl:ENSBTAG00000021007 | folate receptor 1 (adult)Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2348 |
RELA | GeneProduct | ensembl:ENSBTAG00000013895 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5970 |
CCL2 | GeneProduct | ensembl:ENSBTAG00000037811 | Monocyte Chemotactic Protein 1CCL2Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6347 |
TP53 | GeneProduct | ensembl:ENSBTAG00000001069 | tumor protein p53Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7157 |
SLC19A1 | GeneProduct | ensembl:ENSBTAG00000024162 | solute carrier family 19 (folate transporter), member 1Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6573 |
NFKB2 | GeneProduct | ensembl:ENSBTAG00000006017 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4791 |
FOLR2 | GeneProduct | ensembl:ENSBTAG00000027684 | folate receptor 2 (fetal)Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2350 |
SLC46A1 | GeneProduct | ensembl:ENSBTAG00000002817 | solute carrier family 46 (folate transporter), member 1Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:113235 |
MTHFD2 | Protein | ensembl:ENSBTAG00000004881 | EC 3.5.4.9methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolaseHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:10797 |
MTRR | Protein | ensembl:ENSBTAG00000009401 | EC 1.16.1.85-methyltetrahydrofolate-homocysteine methyltransferase reductaseHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:4552 |
MAT1A | Protein | ensembl:ENSBTAG00000005963 | EC 2.5.1.6Methionine adenosyltransferaseHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:4143 |
MTHFD1 | Protein | ensembl:ENSBTAG00000009641 | EC 1.5.1.5methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4522 |
MTR | Protein | ensembl:ENSBTAG00000012251 | EC 2.1.1.135-methyltetrahydrofolate-homocysteine methyltransferaseAlso known as MSHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:4548 |
AHCY | Protein | ensembl:ENSBTAG00000018101 | EC 3.3.1.1AdenosylhomocysteinaseHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:191 |
SHMT2 | Protein | ensembl:ENSBTAG00000031500 | EC 2.1.2.1Serine hydroxymethyltransferaseHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:6472 |
DHFR | Protein | ensembl:ENSBTAG00000007681 | EC 1.5.1.3Dihydrofolate reductaseHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:1719 |
CBS | Protein | ensembl:ENSBTAG00000000160 | EC 4.2.1.22cystathionine-beta-synthaseHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:875 |
MPO | Protein | ensembl:ENSBTAG00000011616 | EC 1.11.1.7MyeloperoxidaseHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:4353 |
CAT | Protein | ensembl:ENSBTAG00000020980 | EC 1.11.1.6Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:847 |
PLAT | Protein | ensembl:ENSBTAG00000001244 | EC 3.4.21.68plasminogen activator, tissueHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:5327 |
F7 | Protein | ensembl:ENSBTAG00000007411 | EC 3.4.21.21coagulation factor VII (serum prothrombin conversion accelerator)Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2155 |
PLG | Protein | ensembl:ENSBTAG00000001271 | EC 3.4.21.7PlasminogenHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:5340 |
F2 | Protein | ensembl:ENSBTAG00000007148 | EC 3.4.21.5coagulation factor II (thrombin)Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2147 |
SERPINE1 | Protein | ensembl:ENSBTAG00000014465 | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5054 |
GPX 4 | Protein | ensembl:ENSBTAG00000046926 | EC 1.11.1.12Selenoprotein-glutathione peroxidase 4Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2879 |
SOD3 | Protein | ensembl:ENSBTAG00000013980 | EC 1.15.1.1superoxide dismutase 3, extracellularHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:6649 |
RFK | Protein | ensembl:ENSBTAG00000019345 | EC 2.7.1.26riboflavin kinaseHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:55312 |
GPX3 | Protein | ensembl:ENSBTAG00000043553 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 3Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2878 |
CTH | Protein | ensembl:ENSBTAG00000014791 | EC 4.4.1.1cystathionaseHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:1491 |
GPX6 | Protein | ensembl:ENSBTAG00000012023 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 6Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:257202 |
GPX2 | Protein | ensembl:ENSBTAG00000048112 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 2Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2877 |
MTHFR | Protein | ensembl:ENSBTAG00000020698 | EC 1.5.1.205,10-methylenetetrahydrofolate reductaseHomozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower than those without the polymorphism increasing the risk of hyperhomocysteinemiaHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:4524 |
GART | Protein | ensembl:ENSBTAG00000009188 | EC 2.1.2.2phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:2618 |
MTHFS | Protein | ensembl:ENSBTAG00000020023 | EC 6.3.3.25,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10588 |
SHMT1 | Protein | ensembl:ENSBTAG00000017094 | EC 2.1.2.1Serine hydroxymethyltransferase 1 (soluble)Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6470 |
SOD1 | Protein | ensembl:ENSBTAG00000027412 | EC 1.15.1.1superoxide dismutase 1, solubleHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:6647 |
SERPINA3-7 | Protein | ensembl:ENSBTAG00000026917 | alpha-1-antichymotrypsinserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:12 |
APOB | Protein | ensembl:ENSBTAG00000008505 | apolipoprotein BHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:338 |
APOA1 | Protein | ensembl:ENSBTAG00000002258 | apolipoprotein A-IHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:335 |
ABCA1 | Protein | ensembl:ENSBTAG00000020661 | ATP-binding cassette, sub-family A (ABC1), member 1Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:19 |
SAA4 | Protein | ensembl:ENSBTAG00000002963 | serum amyloid A4, constitutiveHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:6291 |
SCARB1 | Protein | ensembl:ENSBTAG00000014269 | scavenger receptor class B, member 1Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:949 |
APOA1 | Protein | ensembl:ENSBTAG00000002258 | Nitrotyrosinated apolipoprotein A-IHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:335 |
LDLR | Protein | ensembl:ENSBTAG00000012314 | low density lipoprotein receptorHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:3949 |
SOD2 | Protein | ensembl:ENSBTAG00000006523 | EC 1.15.1.1superoxide dismutase 2, mitochondrialHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:6648 |
IL1B | Protein | ensembl:ENSBTAG00000001321 | interleukin 1, betaHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:3553 |
IL2 | Protein | ensembl:ENSBTAG00000020883 | interleukin 2Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3558 |
CRP | Protein | ensembl:ENSBTAG00000013907 | C-reactive protein, pentraxin-relatedHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:1401 |
HBG | Protein | ensembl:ENSBTAG00000037644 | hemoglobin, betaHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:3043 |
INSR | Protein | ensembl:ENSBTAG00000012687 | Insulin receptorHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:3643 |
HBA | Protein | ensembl:ENSBTAG00000026418 | hemoglobin, alpha 1Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3039 |
IFNG | Protein | ensembl:ENSBTAG00000012529 | interferon, gammaHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:3458 |
IL4 | Protein | ensembl:ENSBTAG00000015957 | interleukin 4Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3565 |
CSF1 | Protein | ensembl:ENSBTAG00000000283 | colony stimulating factor 1 (macrophage)Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1435 |
ALB | Protein | ensembl:ENSBTAG00000017121 | albuminHomology Mapping from Homo sapiens to Bos taurus: Original ID = L:213 |
ICAM1 | Protein | ensembl:ENSBTAG00000010303 | soluble intercellular adhesion molecule 1Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3383 |
TNF | Protein | ensembl:ENSBTAG00000025471 | tumor necrosis factor (TNF superfamily, member 2)Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7124 |
IL6 | Protein | ensembl:ENSBTAG00000014921 | interleukin 6 (interferon, beta 2)Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3569 |
FLAD1 | Protein | ensembl:ENSBTAG00000000186 | EC 2.7.7.2FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:80308 |
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