Estrogen metabolism (WP1053)

Bos taurus

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Authors

Alex Pico , Nuno , Egon Willighagen , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

C18-steroid hormone biosynthetic pathway

Participants

Label Type Compact URI Comment
2-Hydroxyestrone Metabolite hmdb:HMDB0000343
Estrone Metabolite hmdb:HMDB0000145
2-Hydroxyestradiol Metabolite hmdb:HMDB0000338
Estrone sulfate Metabolite hmdb:HMDB0001425
Oxygen Metabolite hmdb:HMDB0001377
Estrone-2,3-quinone Metabolite pubchem.compound:148381
16a-Hydroxyestrone Metabolite hmdb:HMDB0000335
2-Methoxyestrone 3-glucuronide Metabolite hmdb:HMDB0004482
Estradiol-3-glucuronide Metabolite hmdb:HMDB0006224
Superoxide Metabolite hmdb:HMDB0002168
2-Methoxyestradiol Metabolite hmdb:HMDB0000405
Estrone-17-glucuronide Metabolite hmdb:HMDB0004483
4-Methoxyestradiol Metabolite hmdb:HMDB0000405
Estrone-3-glucuronide Metabolite hmdb:HMDB0004483
2-Methoxyestrone Metabolite hmdb:HMDB0000010
Estrone-3,4-quinone Metabolite pubchem.compound:114862
COMT GeneProduct ensembl:ENSBTAG00000019516 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000093010
CYP1A2 GeneProduct ensembl:ENSBTAG00000000085 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
UGT1A1 GeneProduct ensembl:ENSBTAG00000026181 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54658
SULT1E1 GeneProduct ensembl:ENSBTAG00000011952 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109193
SULT1A1 GeneProduct ensembl:ENSBTAG00000008635 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196502
ARSE GeneProduct ensembl:ENSBTAG00000014932 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157399
UGT2B7 GeneProduct ensembl:ENSBTAG00000040337 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171234
NQO1 GeneProduct ensembl:ENSBTAG00000020632 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181019
CYP3A4 GeneProduct ensembl:ENSBTAG00000047379 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
CYP1A1 GeneProduct ensembl:ENSBTAG00000001021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465
GSTA2 GeneProduct ensembl:ENSBTAG00000006546 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243955
UGT1A3 GeneProduct ensembl:ENSBTAG00000048275 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54659
STS GeneProduct ensembl:ENSBTAG00000020789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:412
CYP1B1 GeneProduct ensembl:ENSBTAG00000010531 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061

References

  1. Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, et al. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10937–42. PubMed Europe PMC Scholia
  2. Estrogen metabolism by conjugation. Raftogianis R, Creveling C, Weinshilboum R, Weisz J. J Natl Cancer Inst Monogr. 2000;(27):113–24. PubMed Europe PMC Scholia
  3. 2-Methoxyestradiol, a promising anticancer agent. Lakhani NJ, Sarkar MA, Venitz J, Figg WD. Pharmacotherapy. 2003 Feb;23(2):165–72. PubMed Europe PMC Scholia
  4. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM. Mol Endocrinol. 2003 Jul;17(7):1344–55. PubMed Europe PMC Scholia
  5. Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, et al. Carcinogenesis. 2003 Apr;24(4):697–702. PubMed Europe PMC Scholia
  6. Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Guillemette C, Bélanger A, Lépine J. Breast Cancer Res. 2004;6(6):246–54. PubMed Europe PMC Scholia
  7. Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases. Abel EL, Lyon RP, Bammler TK, Verlinde CLMJ, Lau SS, Monks TJ, et al. Chem Biol Interact. 2004 Dec 30;151(1):21–32. PubMed Europe PMC Scholia
  8. Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL. Breast Cancer Res. 2005;7(6):R909-21. PubMed Europe PMC Scholia