G protein signaling pathways (WP1049)

Bos taurus

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: [[wikipedia:G_protein|Wikipedia]]

Authors

Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

G protein mediated signaling pathway via Galpha12/Galpha13 family G protein mediated signaling pathway G protein mediated signaling pathway via Galphas family G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphai family

Participants

Label Type Compact URI Comment
IP3 Metabolite hmdb:HMDB0001143
Ca2+ Metabolite hmdb:HMDB0000464
DAG Metabolite kegg.compound:C00165
cAMP Metabolite hmdb:HMDB0000058
PRKAR2B GeneProduct ensembl:ENSBTAG00000014958 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5577
GNG10 GeneProduct ensembl:ENSBTAG00000009087 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2790
PDE7B GeneProduct ensembl:ENSBTAG00000015888 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27115
ADCY3 GeneProduct ensembl:ENSBTAG00000018705 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:109
ADCY5 GeneProduct ensembl:ENSBTAG00000018777 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:111
GNG12 GeneProduct ensembl:ENSBTAG00000035697 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55970
GNG11 GeneProduct ensembl:ENSBTAG00000000820 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2791
AKAP8 GeneProduct ensembl:ENSBTAG00000001807 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10270
PPP3CC GeneProduct ensembl:ENSBTAG00000020133 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5533
AKAP1 GeneProduct ensembl:ENSBTAG00000025320 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8165
PRKAR1B GeneProduct ensembl:ENSBTAG00000046142 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5575
GNAS GeneProduct ensembl:ENSBTAG00000017475 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778
PRKCD GeneProduct ensembl:ENSBTAG00000008719 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
GNB3 GeneProduct ensembl:ENSBTAG00000016043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2784
PDE4A GeneProduct ensembl:ENSBTAG00000012032 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5141
PDE1B GeneProduct ensembl:ENSBTAG00000004337 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5153
GNAQ GeneProduct ensembl:ENSBTAG00000009789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
GNAO1 GeneProduct ensembl:ENSBTAG00000003794 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2775
PDE4D GeneProduct ensembl:ENSBTAG00000000494 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5144
PRKCB GeneProduct ensembl:ENSBTAG00000020921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
RRAS GeneProduct ensembl:ENSBTAG00000020983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6237
GNA14 GeneProduct ensembl:ENSBTAG00000021127 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9630
AKAP5 GeneProduct ensembl:ENSBTAG00000009642 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9495
GNAZ GeneProduct ensembl:ENSBTAG00000047664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2781
ADCY4 GeneProduct ensembl:ENSBTAG00000018419 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:196883
PDE8B GeneProduct ensembl:ENSBTAG00000020205 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8622
NRAS GeneProduct ensembl:ENSBTAG00000046797 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893
GNG13 GeneProduct ensembl:ENSBTAG00000033526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51764
GNGT1 GeneProduct ensembl:ENSBTAG00000002674 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2792
GNB2 GeneProduct ensembl:ENSBTAG00000006495 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2783
PRKAR1A GeneProduct ensembl:ENSBTAG00000008621 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5573
GNA11 GeneProduct ensembl:ENSBTAG00000012181 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2767
PRKCH GeneProduct ensembl:ENSBTAG00000003276 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5583
PPP3CA GeneProduct ensembl:ENSBTAG00000016005 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5530
GNAI1 GeneProduct ensembl:ENSBTAG00000002714 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2770
PRKACB GeneProduct ensembl:ENSBTAG00000011953 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5567
PRKAR2A GeneProduct ensembl:ENSBTAG00000014205 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5576
GNB5 GeneProduct ensembl:ENSBTAG00000003762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10681
KCNJ3 GeneProduct ensembl:ENSBTAG00000006159 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3760
PLCB3 GeneProduct ensembl:ENSBTAG00000012510 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5331
AKAP7 GeneProduct ensembl:ENSBTAG00000000240 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9465
GNA13 GeneProduct ensembl:ENSBTAG00000046174 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10672
ADCY6 GeneProduct ensembl:ENSBTAG00000005464 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:112
AKAP3 GeneProduct ensembl:ENSBTAG00000001020 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10566
PDE1A GeneProduct ensembl:ENSBTAG00000012100 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5136
PDE1C GeneProduct ensembl:ENSBTAG00000002739 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5137
ADCY2 GeneProduct ensembl:ENSBTAG00000019210 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:108
GNAL GeneProduct ensembl:ENSBTAG00000002125 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2774
PRKD1 GeneProduct ensembl:ENSBTAG00000012789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
PRKD3 GeneProduct ensembl:ENSBTAG00000001114 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23683
ADCY9 GeneProduct ensembl:ENSBTAG00000016629 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:115
AKAP6 GeneProduct ensembl:ENSBTAG00000017719 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9472
ADCY1 GeneProduct ensembl:ENSBTAG00000009520 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:107
AKAP13 GeneProduct ensembl:ENSBTAG00000037383 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11214
GNA15 GeneProduct ensembl:ENSBTAG00000019988 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2769
PDE8A GeneProduct ensembl:ENSBTAG00000015909 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5151
AKAP12 GeneProduct ensembl:ENSBTAG00000014788 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9590
RHOA GeneProduct ensembl:ENSBTAG00000004279 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
AKAP4 GeneProduct ensembl:ENSBTAG00000016399 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8852
GNAI3 GeneProduct ensembl:ENSBTAG00000013016 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2773
AKAP11 GeneProduct ensembl:ENSBTAG00000014752 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11215
GNGT2 GeneProduct ensembl:ENSBTAG00000047325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2793
PRKCQ GeneProduct ensembl:ENSBTAG00000010664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5588
PDE4C GeneProduct ensembl:ENSBTAG00000010652 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5143
GNG8 GeneProduct ensembl:ENSBTAG00000017762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:94235
PRKCE GeneProduct ensembl:ENSBTAG00000020614 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5581
GNG7 GeneProduct ensembl:ENSBTAG00000007644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2788
PRKCG GeneProduct ensembl:ENSBTAG00000013550 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5582
GNB1 GeneProduct ensembl:ENSBTAG00000000215 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782
PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PRKCI GeneProduct ensembl:ENSBTAG00000001403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5584
GNG5 GeneProduct ensembl:ENSBTAG00000008122 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2787
GNG3 GeneProduct ensembl:ENSBTAG00000002508 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2785
HRAS GeneProduct ensembl:ENSBTAG00000046644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
PRKCZ GeneProduct ensembl:ENSBTAG00000014119 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590
ARHGEF1 GeneProduct ensembl:ENSBTAG00000018912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9138
AKAP10 GeneProduct ensembl:ENSBTAG00000003439 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11216
ADCY8 GeneProduct ensembl:ENSBTAG00000014600 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114
ADCY7 GeneProduct ensembl:ENSBTAG00000006208 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:113
PRKACA GeneProduct ensembl:ENSBTAG00000006642 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5566
PDE4B GeneProduct ensembl:ENSBTAG00000008636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5142
PDE7A GeneProduct ensembl:ENSBTAG00000011614 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5150
AKAP9 GeneProduct ensembl:ENSBTAG00000007442 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10142
GNG4 GeneProduct ensembl:ENSBTAG00000002908 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2786
GNA12 GeneProduct ensembl:ENSBTAG00000017871 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2768
ITPR1 GeneProduct ensembl:ENSBTAG00000020455 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3708
SLC9A1 GeneProduct ensembl:ENSBTAG00000008766 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6548
GNAI2 GeneProduct ensembl:ENSBTAG00000020645 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2771

References

  1. G proteins: a family of signal transducers. Stryer L, Bourne HR. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
  2. G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia