G protein signaling pathways (WP1049)
Bos taurus
G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: [[wikipedia:G_protein|Wikipedia]]
Authors
Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric WeitzActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
G protein mediated signaling pathway via Galpha12/Galpha13 family G protein mediated signaling pathway G protein mediated signaling pathway via Galphas family G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphai family| Label | Type | Compact URI | Comment |
|---|---|---|---|
| IP3 | Metabolite | hmdb:HMDB0001143 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| DAG | Metabolite | kegg.compound:C00165 | |
| cAMP | Metabolite | hmdb:HMDB0000058 | |
| PRKAR2B | GeneProduct | ensembl:ENSBTAG00000014958 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5577 |
| GNG10 | GeneProduct | ensembl:ENSBTAG00000009087 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2790 |
| PDE7B | GeneProduct | ensembl:ENSBTAG00000015888 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27115 |
| ADCY3 | GeneProduct | ensembl:ENSBTAG00000018705 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:109 |
| ADCY5 | GeneProduct | ensembl:ENSBTAG00000018777 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:111 |
| GNG12 | GeneProduct | ensembl:ENSBTAG00000035697 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55970 |
| GNG11 | GeneProduct | ensembl:ENSBTAG00000000820 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2791 |
| AKAP8 | GeneProduct | ensembl:ENSBTAG00000001807 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10270 |
| PPP3CC | GeneProduct | ensembl:ENSBTAG00000020133 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5533 |
| AKAP1 | GeneProduct | ensembl:ENSBTAG00000025320 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8165 |
| PRKAR1B | GeneProduct | ensembl:ENSBTAG00000046142 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5575 |
| GNAS | GeneProduct | ensembl:ENSBTAG00000017475 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778 |
| PRKCD | GeneProduct | ensembl:ENSBTAG00000008719 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580 |
| GNB3 | GeneProduct | ensembl:ENSBTAG00000016043 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2784 |
| PDE4A | GeneProduct | ensembl:ENSBTAG00000012032 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5141 |
| PDE1B | GeneProduct | ensembl:ENSBTAG00000004337 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5153 |
| GNAQ | GeneProduct | ensembl:ENSBTAG00000009789 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776 |
| GNAO1 | GeneProduct | ensembl:ENSBTAG00000003794 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2775 |
| PDE4D | GeneProduct | ensembl:ENSBTAG00000000494 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5144 |
| PRKCB | GeneProduct | ensembl:ENSBTAG00000020921 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579 |
| RRAS | GeneProduct | ensembl:ENSBTAG00000020983 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6237 |
| GNA14 | GeneProduct | ensembl:ENSBTAG00000021127 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9630 |
| AKAP5 | GeneProduct | ensembl:ENSBTAG00000009642 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9495 |
| GNAZ | GeneProduct | ensembl:ENSBTAG00000047664 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2781 |
| ADCY4 | GeneProduct | ensembl:ENSBTAG00000018419 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:196883 |
| PDE8B | GeneProduct | ensembl:ENSBTAG00000020205 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8622 |
| NRAS | GeneProduct | ensembl:ENSBTAG00000046797 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893 |
| GNG13 | GeneProduct | ensembl:ENSBTAG00000033526 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51764 |
| GNGT1 | GeneProduct | ensembl:ENSBTAG00000002674 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2792 |
| GNB2 | GeneProduct | ensembl:ENSBTAG00000006495 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2783 |
| PRKAR1A | GeneProduct | ensembl:ENSBTAG00000008621 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5573 |
| GNA11 | GeneProduct | ensembl:ENSBTAG00000012181 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2767 |
| PRKCH | GeneProduct | ensembl:ENSBTAG00000003276 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5583 |
| PPP3CA | GeneProduct | ensembl:ENSBTAG00000016005 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5530 |
| GNAI1 | GeneProduct | ensembl:ENSBTAG00000002714 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2770 |
| PRKACB | GeneProduct | ensembl:ENSBTAG00000011953 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5567 |
| PRKAR2A | GeneProduct | ensembl:ENSBTAG00000014205 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5576 |
| GNB5 | GeneProduct | ensembl:ENSBTAG00000003762 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10681 |
| KCNJ3 | GeneProduct | ensembl:ENSBTAG00000006159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3760 |
| PLCB3 | GeneProduct | ensembl:ENSBTAG00000012510 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5331 |
| AKAP7 | GeneProduct | ensembl:ENSBTAG00000000240 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9465 |
| GNA13 | GeneProduct | ensembl:ENSBTAG00000046174 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10672 |
| ADCY6 | GeneProduct | ensembl:ENSBTAG00000005464 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:112 |
| AKAP3 | GeneProduct | ensembl:ENSBTAG00000001020 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10566 |
| PDE1A | GeneProduct | ensembl:ENSBTAG00000012100 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5136 |
| PDE1C | GeneProduct | ensembl:ENSBTAG00000002739 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5137 |
| ADCY2 | GeneProduct | ensembl:ENSBTAG00000019210 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:108 |
| GNAL | GeneProduct | ensembl:ENSBTAG00000002125 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2774 |
| PRKD1 | GeneProduct | ensembl:ENSBTAG00000012789 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587 |
| PRKD3 | GeneProduct | ensembl:ENSBTAG00000001114 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23683 |
| ADCY9 | GeneProduct | ensembl:ENSBTAG00000016629 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:115 |
| AKAP6 | GeneProduct | ensembl:ENSBTAG00000017719 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9472 |
| ADCY1 | GeneProduct | ensembl:ENSBTAG00000009520 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:107 |
| AKAP13 | GeneProduct | ensembl:ENSBTAG00000037383 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11214 |
| GNA15 | GeneProduct | ensembl:ENSBTAG00000019988 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2769 |
| PDE8A | GeneProduct | ensembl:ENSBTAG00000015909 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5151 |
| AKAP12 | GeneProduct | ensembl:ENSBTAG00000014788 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9590 |
| RHOA | GeneProduct | ensembl:ENSBTAG00000004279 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387 |
| AKAP4 | GeneProduct | ensembl:ENSBTAG00000016399 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8852 |
| GNAI3 | GeneProduct | ensembl:ENSBTAG00000013016 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2773 |
| AKAP11 | GeneProduct | ensembl:ENSBTAG00000014752 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11215 |
| GNGT2 | GeneProduct | ensembl:ENSBTAG00000047325 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2793 |
| PRKCQ | GeneProduct | ensembl:ENSBTAG00000010664 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5588 |
| PDE4C | GeneProduct | ensembl:ENSBTAG00000010652 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5143 |
| GNG8 | GeneProduct | ensembl:ENSBTAG00000017762 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:94235 |
| PRKCE | GeneProduct | ensembl:ENSBTAG00000020614 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5581 |
| GNG7 | GeneProduct | ensembl:ENSBTAG00000007644 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2788 |
| PRKCG | GeneProduct | ensembl:ENSBTAG00000013550 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5582 |
| GNB1 | GeneProduct | ensembl:ENSBTAG00000000215 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782 |
| PRKCA | GeneProduct | ensembl:ENSBTAG00000001061 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578 |
| PRKCI | GeneProduct | ensembl:ENSBTAG00000001403 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5584 |
| GNG5 | GeneProduct | ensembl:ENSBTAG00000008122 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2787 |
| GNG3 | GeneProduct | ensembl:ENSBTAG00000002508 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2785 |
| HRAS | GeneProduct | ensembl:ENSBTAG00000046644 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265 |
| PRKCZ | GeneProduct | ensembl:ENSBTAG00000014119 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590 |
| ARHGEF1 | GeneProduct | ensembl:ENSBTAG00000018912 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9138 |
| AKAP10 | GeneProduct | ensembl:ENSBTAG00000003439 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11216 |
| ADCY8 | GeneProduct | ensembl:ENSBTAG00000014600 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114 |
| ADCY7 | GeneProduct | ensembl:ENSBTAG00000006208 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:113 |
| PRKACA | GeneProduct | ensembl:ENSBTAG00000006642 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5566 |
| PDE4B | GeneProduct | ensembl:ENSBTAG00000008636 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5142 |
| PDE7A | GeneProduct | ensembl:ENSBTAG00000011614 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5150 |
| AKAP9 | GeneProduct | ensembl:ENSBTAG00000007442 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10142 |
| GNG4 | GeneProduct | ensembl:ENSBTAG00000002908 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2786 |
| GNA12 | GeneProduct | ensembl:ENSBTAG00000017871 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2768 |
| ITPR1 | GeneProduct | ensembl:ENSBTAG00000020455 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3708 |
| SLC9A1 | GeneProduct | ensembl:ENSBTAG00000008766 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6548 |
| GNAI2 | GeneProduct | ensembl:ENSBTAG00000020645 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2771 |
References
- G proteins: a family of signal transducers. Stryer L, Bourne HR. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
- G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia