TGF-beta receptor signaling (WP1048)

Bos taurus

The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: [http://en.wikipedia.org/wiki/TGF_beta_signaling_pathway WikiPedia]). Also see: [http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=200110&source=NCI-Nature%20curated&what=graphic&gif=on&ppage=1 TGF-beta receptor signaling] at the NCI-Nature pathway interaction database.

Authors

Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

transforming growth factor-beta superfamily mediated signaling pathway

Participants

Label Type Compact URI Comment
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
INHBA GeneProduct ensembl:ENSBTAG00000002912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624
BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:652
TGFBR3 GeneProduct ensembl:ENSBTAG00000024269 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7049
ENG GeneProduct ensembl:ENSBTAG00000008997 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2022
TGFBR2 GeneProduct ensembl:ENSBTAG00000019832 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7048
TGFBR1 GeneProduct ensembl:ENSBTAG00000018035 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7046
FKBP1A GeneProduct ensembl:ENSBTAG00000032651 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2280
LTBP1 GeneProduct ensembl:ENSBTAG00000019839 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4052
FST GeneProduct ensembl:ENSBTAG00000003329 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10468
NOG GeneProduct ensembl:ENSBTAG00000040282 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9241
ITGB6 GeneProduct ensembl:ENSBTAG00000009080 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3694
THBS1 GeneProduct ensembl:ENSBTAG00000002006 there are 5 types of tsp
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7057
ZFYVE9 GeneProduct ensembl:ENSBTAG00000014289 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9372
SMAD1 GeneProduct ensembl:ENSBTAG00000002835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4086
SMAD5 GeneProduct ensembl:ENSBTAG00000021772 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4090
SMAD9 GeneProduct ensembl:ENSBTAG00000007589 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4093
SMAD2 GeneProduct ensembl:ENSBTAG00000039916 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4087
SMAD3 GeneProduct ensembl:ENSBTAG00000012599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088
SMAD4 GeneProduct ensembl:ENSBTAG00000006919 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
IFNG GeneProduct ensembl:ENSBTAG00000012529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
TNF GeneProduct ensembl:ENSBTAG00000025471 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
SMAD7 GeneProduct ensembl:ENSBTAG00000012441 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4092
SMAD6 GeneProduct ensembl:ENSBTAG00000000625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4091
MAPK3 GeneProduct ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
HRAS GeneProduct ensembl:ENSBTAG00000046644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
WNT1 GeneProduct ensembl:ENSBTAG00000015364 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7471
CTNNB1 GeneProduct ensembl:ENSBTAG00000016420 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
JAK1 GeneProduct ensembl:ENSBTAG00000003147 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
MAPK9 GeneProduct ensembl:ENSBTAG00000004709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
SPP1 GeneProduct ensembl:ENSBTAG00000005260 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6696
ZEB2 GeneProduct ensembl:ENSBTAG00000012615 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9839
RUNX2 GeneProduct ensembl:ENSBTAG00000004104 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:860
RUNX3 GeneProduct ensembl:ENSBTAG00000019800 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:864
LEF1 GeneProduct ensembl:ENSBTAG00000006844 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51176
STAT3 GeneProduct ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
JUN GeneProduct ensembl:ENSBTAG00000004037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
TFE3 GeneProduct ensembl:ENSBTAG00000008523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7030
FOXH1 GeneProduct ensembl:ENSBTAG00000004761 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8928
ZNF423 GeneProduct ensembl:ENSBTAG00000017397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23090
EP300 GeneProduct ensembl:ENSBTAG00000016198 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
CREBBP GeneProduct ensembl:ENSBTAG00000026403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1387
TGIF1 GeneProduct ensembl:ENSBTAG00000007718 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7050
SKIL GeneProduct ensembl:ENSBTAG00000004154 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6498
SKI GeneProduct ensembl:ENSBTAG00000038716 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6497
SERPINE1 GeneProduct ensembl:ENSBTAG00000014465 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5054
FOS GeneProduct ensembl:ENSBTAG00000004322 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
LIF GeneProduct ensembl:ENSBTAG00000007424 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3976
BAMBI GeneProduct ensembl:ENSBTAG00000003045 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25805
bta-mir-302a GeneProduct ensembl:ENSBTAG00000036428 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207927
LEFTY1 GeneProduct ensembl:ENSBTAG00000002855 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10637
LEFTY2 GeneProduct ensembl:ENSBTAG00000002855 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7044

References

  1. TGFbeta signaling in growth control, cancer, and heritable disorders. Massagué J, Blain SW, Lo RS. Cell. 2000 Oct 13;103(2):295–309. PubMed Europe PMC Scholia
  2. How cells read TGF-beta signals. Massagué J. Nat Rev Mol Cell Biol. 2000 Dec;1(3):169–78. PubMed Europe PMC Scholia
  3. MicroRNAs as regulators of differentiation and cell fate decisions. Ivey KN, Srivastava D. Cell Stem Cell. 2010 Jul 2;7(1):36–41. PubMed Europe PMC Scholia