Calcium regulation in cardiac cell (WP1043)

Bos taurus

Calcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular compartment to the intracellular compartment alters membrane depolarisation. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarisation of the heart. Source: [[wikipedia:Calcium_signaling|Wikipedia]]

Authors

Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Disease Ontology

cardiovascular system disease

Pathway Ontology

calcium/calcium-mediated signaling pathway

Cell Type Ontology

cardiac muscle cell

Participants

Label Type Compact URI Comment
ATP Metabolite cas:1927-31-7
Epinephrine Metabolite hmdb:HMDB0000068
Na+ Metabolite hmdb:HMDB0000588
Acetylcholine Metabolite cas:51-84-3
Pi Metabolite hmdb:HMDB0001429
IP4 Metabolite chebi:16783
IP3 Metabolite chemspider:388562
ADP Metabolite cas:58-64-0
K+ Metabolite hmdb:HMDB0000586
Ca2+ Metabolite hmdb:HMDB0000464
cAMP Metabolite pubchem.compound:6076
PIP2 Metabolite hmdb:HMDB0010032
ADP Metabolite hmdb:HMDB0001341
CACNB1 GeneProduct ensembl:ENSBTAG00000002036 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:782
CAMK2G GeneProduct ensembl:ENSBTAG00000012667 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:818
RYR2 GeneProduct ensembl:ENSBTAG00000022886 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6262
RGS6 GeneProduct ensembl:ENSBTAG00000014189 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9628
ADCY4 GeneProduct ensembl:ENSBTAG00000018419 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:196883
GNG2 GeneProduct ensembl:ENSBTAG00000003043 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:54331
ADCY1 GeneProduct ensembl:ENSBTAG00000009520 CYA1 HUMAN
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:107
CAMK2A GeneProduct ensembl:ENSBTAG00000020087 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:815
PRKCB GeneProduct ensembl:ENSBTAG00000020921 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5579
CACNA1E GeneProduct ensembl:ENSBTAG00000020887 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:777
GNG13 GeneProduct ensembl:ENSBTAG00000033526 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51764
RGS1 GeneProduct ensembl:ENSBTAG00000021672 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5996
ATP2B1 GeneProduct ensembl:ENSBTAG00000009552 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:490
PRKACA GeneProduct ensembl:ENSBTAG00000006642 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5566
GNAI2 GeneProduct ensembl:ENSBTAG00000020645 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2771
ATP2A3 GeneProduct ensembl:ENSBTAG00000014806 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:489
ATP2B3 GeneProduct ensembl:ENSBTAG00000000520 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:492
GJA5 GeneProduct ensembl:ENSBTAG00000006720 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2702
PLCB3 GeneProduct ensembl:ENSBTAG00000012510 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5331
ADRA1A GeneProduct ensembl:ENSBTAG00000031632 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:148
GNB4 GeneProduct ensembl:ENSBTAG00000002767 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:59345
PLN GeneProduct ensembl:ENSBTAG00000012931 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5350
RGS20 GeneProduct ensembl:ENSBTAG00000003454 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8601
GJA9 GeneProduct ensembl:ENSBTAG00000030338 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:81025
CALM2 GeneProduct ensembl:ENSBTAG00000001575 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:805
PRKACB GeneProduct ensembl:ENSBTAG00000011953 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5567
RYR1 GeneProduct ensembl:ENSBTAG00000006999 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6261
CAMK4 GeneProduct ensembl:ENSBTAG00000035662 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:814
ADCY5 GeneProduct ensembl:ENSBTAG00000018777 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:111
PKIB GeneProduct ensembl:ENSBTAG00000004394 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5570
ARRB2 GeneProduct ensembl:ENSBTAG00000035587 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:409
RGS10 GeneProduct ensembl:ENSBTAG00000002647 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6001
ADRA1D GeneProduct ensembl:ENSBTAG00000019504 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:146
ADRB1 GeneProduct ensembl:ENSBTAG00000001242 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:153
RGS14 GeneProduct ensembl:ENSBTAG00000008497 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10636
CACNA1S GeneProduct ensembl:ENSBTAG00000047491 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:779
CHRM4 GeneProduct ensembl:ENSBTAG00000033699 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1132
CHRM2 GeneProduct ensembl:ENSBTAG00000014674 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1129
CACNA1C GeneProduct ensembl:ENSBTAG00000010660 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:775
GJC1 GeneProduct ensembl:ENSBTAG00000004036 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10052
KCNB1 GeneProduct ensembl:ENSBTAG00000027320 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3745
ADCY2 GeneProduct ensembl:ENSBTAG00000019210 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:108
GJA1 GeneProduct ensembl:ENSBTAG00000001835 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2697
ITPR2 GeneProduct ensembl:ENSBTAG00000002313 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3709
PRKAR1B GeneProduct ensembl:ENSBTAG00000046142 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5575
CACNA1D GeneProduct ensembl:ENSBTAG00000010026 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:776
CAMK2D GeneProduct ensembl:ENSBTAG00000014463 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:817
GNB3 GeneProduct ensembl:ENSBTAG00000016043 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2784
CACNA1A GeneProduct ensembl:ENSBTAG00000014828 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:773
KCNJ3 GeneProduct ensembl:ENSBTAG00000006159 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3760
RGS5 GeneProduct ensembl:ENSBTAG00000016341 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8490
YWHAB GeneProduct ensembl:ENSBTAG00000016846 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7529
GNB5 GeneProduct ensembl:ENSBTAG00000003762 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10681
KCNJ5 GeneProduct ensembl:ENSBTAG00000006902 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3762
YWHAZ GeneProduct ensembl:ENSBTAG00000000236 PMID: 9861170 PMID: 1317796
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7534
YWHAH GeneProduct ensembl:ENSBTAG00000011631 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7533
GJA3 GeneProduct ensembl:ENSBTAG00000020400 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2700
ITPR1 GeneProduct ensembl:ENSBTAG00000020455 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3708
ATP2B2 GeneProduct ensembl:ENSBTAG00000001305 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:491
GJB3 GeneProduct ensembl:ENSBTAG00000012584 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2707
GJB4 GeneProduct ensembl:ENSBTAG00000005719 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:127534
SFN GeneProduct ensembl:ENSBTAG00000009223 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2810
PRKD1 GeneProduct ensembl:ENSBTAG00000012789 KPCM HUMAN
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5587
GNG12 GeneProduct ensembl:ENSBTAG00000035697 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:55970
GNAQ GeneProduct ensembl:ENSBTAG00000009789 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2776
GNG11 GeneProduct ensembl:ENSBTAG00000000820 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2791
PRKCD GeneProduct ensembl:ENSBTAG00000008719 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5580
GNG7 GeneProduct ensembl:ENSBTAG00000007644 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2788
GJB6 GeneProduct ensembl:ENSBTAG00000038662 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10804
GNAI3 GeneProduct ensembl:ENSBTAG00000013016 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2773
PRKCE GeneProduct ensembl:ENSBTAG00000020614 This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5581
RGS18 GeneProduct ensembl:ENSBTAG00000013064 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:64407
RGS7 GeneProduct ensembl:ENSBTAG00000005410 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6000
GRK5 GeneProduct ensembl:ENSBTAG00000007981 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2869
GNG8 GeneProduct ensembl:ENSBTAG00000017762 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:94235
PKIA GeneProduct ensembl:ENSBTAG00000008150 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5569
RYR3 GeneProduct ensembl:ENSBTAG00000025642 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6263
ITPR3 GeneProduct ensembl:ENSBTAG00000013245 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3710
ADCY8 GeneProduct ensembl:ENSBTAG00000014600 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:114
CHRM1 GeneProduct ensembl:ENSBTAG00000011579 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1128
RGS19 GeneProduct ensembl:ENSBTAG00000021837 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10287
ADRA1B GeneProduct ensembl:ENSBTAG00000040253 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:147
CALM2 GeneProduct ensembl:ENSBTAG00000001575 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:808
FKBP1A GeneProduct ensembl:ENSBTAG00000032651 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2280
GJB1 GeneProduct ensembl:ENSBTAG00000020512 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2705
GJA8 GeneProduct ensembl:ENSBTAG00000021833 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2703
RGS17 GeneProduct ensembl:ENSBTAG00000009277 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:26575
CASQ1 GeneProduct ensembl:ENSBTAG00000020223 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:844
ADCY3 GeneProduct ensembl:ENSBTAG00000018705 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:109
YWHAE GeneProduct ensembl:ENSBTAG00000005664 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7531
ANXA6 GeneProduct ensembl:ENSBTAG00000014809 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:309
GNA11 GeneProduct ensembl:ENSBTAG00000012181 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2767
GNG5 GeneProduct ensembl:ENSBTAG00000008122 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2787
ADCY9 GeneProduct ensembl:ENSBTAG00000016629 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:115
RGS16 GeneProduct ensembl:ENSBTAG00000004305 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6004
SLC8A1 GeneProduct ensembl:ENSBTAG00000013861 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6546
YWHAQ GeneProduct ensembl:ENSBTAG00000002108 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10971
ADCY7 GeneProduct ensembl:ENSBTAG00000006208 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:113
GNAZ GeneProduct ensembl:ENSBTAG00000047664 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2781
ADRB3 GeneProduct ensembl:ENSBTAG00000017981 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:155
GJB5 GeneProduct ensembl:ENSBTAG00000005717 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2709
CALR GeneProduct ensembl:ENSBTAG00000015114 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:811
RGS11 GeneProduct ensembl:ENSBTAG00000016574 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8786
GNGT1 GeneProduct ensembl:ENSBTAG00000002674 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2792
PRKCZ GeneProduct ensembl:ENSBTAG00000014119 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5590
PRKAR1A GeneProduct ensembl:ENSBTAG00000008621 KAP0 HUMAN
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5573
GNB2 GeneProduct ensembl:ENSBTAG00000006495 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2783
PKIG GeneProduct ensembl:ENSBTAG00000005275 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11142
RGS4 GeneProduct ensembl:ENSBTAG00000046277 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5999
PRKCH GeneProduct ensembl:ENSBTAG00000003276 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5583
PRKAR2B GeneProduct ensembl:ENSBTAG00000014958 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5577
PRKCQ GeneProduct ensembl:ENSBTAG00000010664 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5588
GNG3 GeneProduct ensembl:ENSBTAG00000002508 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2785
PRKCA GeneProduct ensembl:ENSBTAG00000001061 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5578
GJC2 GeneProduct ensembl:ENSBTAG00000014916 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57165
GNB1 GeneProduct ensembl:ENSBTAG00000000215 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2782
CASQ2 GeneProduct ensembl:ENSBTAG00000011500 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:845
GNAO1 GeneProduct ensembl:ENSBTAG00000003794 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2775
SLC8A3 GeneProduct ensembl:ENSBTAG00000027080 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6547
PLN GeneProduct ensembl:ENSBTAG00000012931 Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000198523
ATP2A2 GeneProduct ensembl:ENSBTAG00000001398 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:488
RGS2 GeneProduct ensembl:ENSBTAG00000034366 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5997
ARRB1 GeneProduct ensembl:ENSBTAG00000020485 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:408
GNAS GeneProduct ensembl:ENSBTAG00000017475 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2778
GJB2 GeneProduct ensembl:ENSBTAG00000017425 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2706
CACNA1B GeneProduct ensembl:ENSBTAG00000007882 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:774
GNAI1 GeneProduct ensembl:ENSBTAG00000002714 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2770
CHRM3 GeneProduct ensembl:ENSBTAG00000008059 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1131
RGS9 GeneProduct ensembl:ENSBTAG00000017751 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8787
CHRM5 GeneProduct ensembl:ENSBTAG00000037985 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1133
CAMK2B GeneProduct ensembl:ENSBTAG00000012653 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:816
GJA4 GeneProduct ensembl:ENSBTAG00000013881 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2701
GNG4 GeneProduct ensembl:ENSBTAG00000002908 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2786
YWHAG GeneProduct ensembl:ENSBTAG00000004077 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7532
CAMK1 GeneProduct ensembl:ENSBTAG00000007780 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8536
CACNB3 GeneProduct ensembl:ENSBTAG00000021808 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:784
PRKCG GeneProduct ensembl:ENSBTAG00000013550 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5582
ADCY6 GeneProduct ensembl:ENSBTAG00000005464 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:112
GRK4 GeneProduct ensembl:ENSBTAG00000001505 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2868
PRKAR2A GeneProduct ensembl:ENSBTAG00000014205 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5576
ADRB2 GeneProduct ensembl:ENSBTAG00000002144 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:154
RGS3 GeneProduct ensembl:ENSBTAG00000004499 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5998
GJD2 GeneProduct ensembl:ENSBTAG00000021730 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57369
GRK6 GeneProduct ensembl:ENSBTAG00000043994 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2870
ATP1A4 GeneProduct ensembl:ENSBTAG00000038523 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:480
ATP1B1 GeneProduct ensembl:ENSBTAG00000002688 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:481
FXYD2 GeneProduct ensembl:ENSBTAG00000009828 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:486
ATP1B2 GeneProduct ensembl:ENSBTAG00000013680 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:482
ATP1B3 GeneProduct ensembl:ENSBTAG00000014140 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:483

References

  1. Calcium and the heart: a question of life and death. Marks AR. J Clin Invest. 2003 Mar;111(5):597–600. PubMed Europe PMC Scholia