Apoptosis (WP1018)

Bos taurus

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Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Authors

Martijn Van Iersel , Kristina Hanspers , Christine Chichester , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

regulatory pathway

Participants

Label Type Compact URI Comment
CASP9 GeneProduct ensembl:ENSBTAG00000002472 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:842
MDM2 GeneProduct ensembl:ENSBTAG00000010422 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4193
BAK1 GeneProduct ensembl:ENSBTAG00000000428 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:578
TRAF3 GeneProduct ensembl:ENSBTAG00000013475 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7187
IRF1 GeneProduct ensembl:ENSBTAG00000031231 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3659
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4790
FAS GeneProduct ensembl:ENSBTAG00000010785 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:355
BIRC2 GeneProduct ensembl:ENSBTAG00000035735 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:329
DIABLO GeneProduct ensembl:ENSBTAG00000004199 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:56616
AKT1 GeneProduct ensembl:ENSBTAG00000017636 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:207
GZMB GeneProduct ensembl:ENSBTAG00000010057 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3002
TNFRSF21 GeneProduct ensembl:ENSBTAG00000020054 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:27242
BAD GeneProduct ensembl:ENSBTAG00000012511 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:572
NFKBIA GeneProduct ensembl:ENSBTAG00000016683 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4792
RIPK1 GeneProduct ensembl:ENSBTAG00000006378 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8737
IRF2 GeneProduct ensembl:ENSBTAG00000010002 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3660
NFKBIB GeneProduct ensembl:ENSBTAG00000001778 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4793
LTA GeneProduct ensembl:ENSBTAG00000000016 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4049
CASP4 GeneProduct ensembl:ENSBTAG00000020884 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:837
IRF6 GeneProduct ensembl:ENSBTAG00000002849 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3664
CASP3 GeneProduct ensembl:ENSBTAG00000015874 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:836
PRF1 GeneProduct ensembl:ENSBTAG00000001008 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5551
TNFRSF1A GeneProduct ensembl:ENSBTAG00000004211 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7132
IGF1R GeneProduct ensembl:ENSBTAG00000021527 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3480
RELA GeneProduct ensembl:ENSBTAG00000013895 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5970
CHUK GeneProduct ensembl:ENSBTAG00000007591 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1147
BAX GeneProduct ensembl:ENSBTAG00000013340 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:581
APAF1 GeneProduct ensembl:ENSBTAG00000021661 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:317
TNFRSF1B GeneProduct ensembl:ENSBTAG00000024928 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7133
BIRC3 GeneProduct ensembl:ENSBTAG00000024918 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:330
BID GeneProduct ensembl:ENSBTAG00000013988 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:637
TNFRSF25 GeneProduct ensembl:ENSBTAG00000006519 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8718
MAPK10 GeneProduct ensembl:ENSBTAG00000020048 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5602
TRAF1 GeneProduct ensembl:ENSBTAG00000003012 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7185
IKBKB GeneProduct ensembl:ENSBTAG00000007599 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3551
IRF5 GeneProduct ensembl:ENSBTAG00000004989 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3663
DFFA GeneProduct ensembl:ENSBTAG00000013535 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1676
CYCS GeneProduct ensembl:ENSBTAG00000022613 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:54205
NFKBIB GeneProduct ensembl:ENSBTAG00000001778 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4793
IRF3 GeneProduct ensembl:ENSBTAG00000006633 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3661
CASP2 GeneProduct ensembl:ENSBTAG00000018159 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:835
HRK GeneProduct ensembl:ENSBTAG00000047484 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8739
TP73 GeneProduct ensembl:ENSBTAG00000005812 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7161
SCAF11 GeneProduct ensembl:ENSBTAG00000001810 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9169
CASP7 GeneProduct ensembl:ENSBTAG00000006615 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:840
MYC GeneProduct ensembl:ENSBTAG00000008409 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4609
TNF GeneProduct ensembl:ENSBTAG00000025471 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7124
IGF2 GeneProduct ensembl:ENSBTAG00000013066 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3481
CRADD GeneProduct ensembl:ENSBTAG00000005107 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8738
IKBKG GeneProduct ensembl:ENSBTAG00000006268 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8517
BOK GeneProduct ensembl:ENSBTAG00000008711 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:666
TRAF2 GeneProduct ensembl:ENSBTAG00000010497 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7186
CFLAR GeneProduct ensembl:ENSBTAG00000010998 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8837
BCL2L2 GeneProduct ensembl:ENSBTAG00000019692 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:599
PIK3R1 GeneProduct ensembl:ENSBTAG00000010989 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5295
TRADD GeneProduct ensembl:ENSBTAG00000012642 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8717
BIRC5 GeneProduct ensembl:ENSBTAG00000013573 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:332
IGF1 GeneProduct ensembl:ENSBTAG00000011082 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3479
TNFRSF10B GeneProduct ensembl:ENSBTAG00000048226 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8795
JUN GeneProduct ensembl:ENSBTAG00000004037 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3725
BNIP3L GeneProduct ensembl:ENSBTAG00000021307 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:665
DFFB GeneProduct ensembl:ENSBTAG00000020015 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1677
TRADD GeneProduct ensembl:ENSBTAG00000012642 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8717
BCL2 GeneProduct ensembl:ENSBTAG00000019302 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:596
TNFRSF1A GeneProduct ensembl:ENSBTAG00000004211 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7132
IRF7 GeneProduct ensembl:ENSBTAG00000047680 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3665
RELA GeneProduct ensembl:ENSBTAG00000013895 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5970
BCL2L1 GeneProduct ensembl:ENSBTAG00000006526 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:598
IRF4 GeneProduct ensembl:ENSBTAG00000002929 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3662
NFKBIE GeneProduct ensembl:ENSBTAG00000013705 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4794
TP53 GeneProduct ensembl:ENSBTAG00000001069 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7157
MAP2K4 GeneProduct ensembl:ENSBTAG00000012103 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6416
RIPK1 GeneProduct ensembl:ENSBTAG00000006378 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8737
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1029
CASP8 GeneProduct ensembl:ENSBTAG00000015718 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:841
BAD GeneProduct ensembl:ENSBTAG00000012511 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:572
NFKBIA GeneProduct ensembl:ENSBTAG00000016683 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4792
FASLG GeneProduct ensembl:ENSBTAG00000032808 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:356
TNFSF10 GeneProduct ensembl:ENSBTAG00000018994 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8743
NFKBIE GeneProduct ensembl:ENSBTAG00000013705 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4794
HELLS GeneProduct ensembl:ENSBTAG00000005979 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3070
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4790
FADD GeneProduct ensembl:ENSBTAG00000018274 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8772
MCL1 GeneProduct ensembl:ENSBTAG00000031396 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4170
CASP6 GeneProduct ensembl:ENSBTAG00000012537 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:839
BCL2L11 GeneProduct ensembl:ENSBTAG00000024105 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10018
MAP3K1 GeneProduct ensembl:ENSBTAG00000013790 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4214
TP63 GeneProduct ensembl:ENSBTAG00000015460 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8626

References

  1. Regulation of p53 in response to DNA damage. Lakin ND, Jackson SP. Oncogene. 1999 Dec 13;18(53):7644–55. PubMed Europe PMC Scholia
  2. mir-29 regulates Mcl-1 protein expression and apoptosis. Mott JL, Kobayashi S, Bronk SF, Gores GJ. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
  3. The p53-MDM2 network: from oscillations to apoptosis. Bose I, Ghosh B. J Biosci. 2007 Aug;32(5):991–7. PubMed Europe PMC Scholia
  4. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Park SY, Lee JH, Ha M, Nam JW, Kim VN. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia