EPO receptor signaling (WP996)
Bos taurus
The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.
Authors
Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric WeitzActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
erythropoietin signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| EPOR | GeneProduct | ensembl:ENSBTAG00000008197 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2057 |
| JAK2 | GeneProduct | ensembl:ENSBTAG00000012047 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717 |
| SRC | GeneProduct | ensembl:ENSBTAG00000008938 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714 |
| STAT1 | GeneProduct | ensembl:ENSBTAG00000007867 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772 |
| SHC1 | GeneProduct | ensembl:ENSBTAG00000019838 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464 |
| GRB2 | GeneProduct | ensembl:ENSBTAG00000004736 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885 |
| MAP2K1 | GeneProduct | ensembl:ENSBTAG00000033983 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604 |
| MAPK3 | GeneProduct | ensembl:ENSBTAG00000016156 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595 |
| MAPK1 | GeneProduct | ensembl:ENSBTAG00000010312 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594 |
| MAP2K2 | GeneProduct | ensembl:ENSBTAG00000024450 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605 |
| PDK1 | GeneProduct | ensembl:ENSBTAG00000016836 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5163 |
| AKT1 | GeneProduct | ensembl:ENSBTAG00000017636 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207 |
| PIK3CG | GeneProduct | ensembl:ENSBTAG00000020848 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5294 |
| EPO | GeneProduct | ensembl:ENSBTAG00000003430 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2056 |
| SOCS1 | GeneProduct | ensembl:ENSBTAG00000004386 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651 |
| STAT5B | GeneProduct | ensembl:ENSBTAG00000010125 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777 |
| CISH | GeneProduct | ensembl:ENSBTAG00000022622 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1154 |
| STAT5A | GeneProduct | ensembl:ENSBTAG00000009496 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776 |
| STAT3 | GeneProduct | ensembl:ENSBTAG00000021523 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774 |
| PTPRC | GeneProduct | ensembl:ENSBTAG00000023144 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5788 |
| PTPRU | GeneProduct | ensembl:ENSBTAG00000012848 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10076 |
| RAF1 | GeneProduct | ensembl:ENSBTAG00000045748 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894 |
| SOS1 | GeneProduct | ensembl:ENSBTAG00000011643 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654 |
| IRS2 | GeneProduct | ensembl:ENSBTAG00000012019 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660 |
| IRS1 | GeneProduct | ensembl:ENSBTAG00000021308 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667 |
| RASA1 | GeneProduct | ensembl:ENSBTAG00000009565 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5921 |
References
- The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
- The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia