G1 to S cell cycle control (WP959)
Pan troglodytes
In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&
Authors
Kristina Hanspers , Christine Chichester , and Martina Summer-KutmonActivity
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Organisms
Pan troglodytesCommunities
Annotations
Pathway Ontology
cell cycle checkpoint pathway G1/S DNA damage checkpoint pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| RB1 | GeneProduct | ensembl:ENSPTRG00000005864 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5925 |
| E2F2 | GeneProduct | ensembl:ENSPTRG00000000330 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1870 |
| E2F1 | GeneProduct | ensembl:ENSPTRG00000013404 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1869 |
| POLE | GeneProduct | ensembl:ENSPTRG00000045365 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5426 |
| CDKN1B | GeneProduct | ensembl:ENSPTRG00000004707 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1027 |
| CDK6 | GeneProduct | ensembl:ENSPTRG00000019400 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1021 |
| PCNA | GeneProduct | ensembl:ENSPTRG00000013222 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5111 |
| CDK4 | GeneProduct | ensembl:ENSPTRG00000005147 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1019 |
| CDKN1A | GeneProduct | ensembl:ENSPTRG00000018107 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1026 |
| CDC45 | GeneProduct | ensembl:ENSPTRG00000014064 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8318 |
| CDK1 | GeneProduct | ensembl:ENSPTRG00000002528 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:983 |
| TP53 | GeneProduct | ensembl:ENSPTRG00000008703 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7157 |
| PRIM2A | GeneProduct | ensembl:ENSPTRG00000044256 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5558 |
| CDKN1C | GeneProduct | ensembl:ENSPTRG00000003182 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1028 |
| CCND2 | GeneProduct | ensembl:ENSPTRG00000004549 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:894 |
| E2F5 | GeneProduct | ensembl:ENSPTRG00000020384 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1875 |
| CCNE1 | GeneProduct | ensembl:ENSPTRG00000010782 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:898 |
| CREB3L4 | GeneProduct | ensembl:ENSPTRG00000001368 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:148327 |
| CDKN2B | GeneProduct | ensembl:ENSPTRG00000049465 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1030 |
| MDM2 | GeneProduct | ensembl:ENSPTRG00000005203 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4193 |
| CDK7 | GeneProduct | ensembl:ENSPTRG00000016946 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1022 |
| CCNG2 | GeneProduct | ensembl:ENSPTRG00000016196 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:901 |
| RPA2 | GeneProduct | ensembl:ENSPTRG00000000420 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6118 |
| CDK4 | GeneProduct | ensembl:ENSPTRG00000005147 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1019 |
| CDK2 | GeneProduct | ensembl:ENSPTRG00000005070 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1017 |
| E2F4 | GeneProduct | ensembl:ENSPTRG00000031180 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1874 |
| TP53 | GeneProduct | ensembl:ENSPTRG00000008703 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7157 |
| CDKN2D | GeneProduct | ensembl:ENSPTRG00000010477 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1032 |
| CDK7 | GeneProduct | ensembl:ENSPTRG00000016946 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1022 |
| CREB3 | GeneProduct | ensembl:ENSPTRG00000020918 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10488 |
| CREB3L3 | GeneProduct | ensembl:ENSPTRG00000010295 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:84699 |
| MYT1 | GeneProduct | ensembl:ENSPTRG00000032477 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4661 |
| TFDP2 | GeneProduct | ensembl:ENSPTRG00000015479 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7029 |
| CCNB1 | GeneProduct | ensembl:ENSPTRG00000016942 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:891 |
| RB1 | GeneProduct | ensembl:ENSPTRG00000005864 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5925 |
| CCND3 | GeneProduct | ensembl:ENSPTRG00000018164 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:896 |
| CCND1 | GeneProduct | ensembl:ENSPTRG00000052519 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:595 |
| CCNH | GeneProduct | ensembl:ENSPTRG00000017063 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:902 |
| MYC | GeneProduct | ensembl:ENSPTRG00000020581 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4609 |
| RPA3 | GeneProduct | ensembl:ENSPTRG00000018927 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6119 |
| MCM4 | GeneProduct | ensembl:ENSPTRG00000020230 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4173 |
| MCM3 | GeneProduct | ensembl:ENSPTRG00000018275 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4172 |
| CREBL1 | GeneProduct | ensembl:ENSPTRG00000043301 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1388 |
| ORC1 | GeneProduct | ensembl:ENSPTRG00000000738 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4998 |
| RB1 | GeneProduct | ensembl:ENSPTRG00000005864 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5925 |
| MCM6 | GeneProduct | ensembl:ENSPTRG00000012498 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4175 |
| MCM7 | GeneProduct | ensembl:ENSPTRG00000019472 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4176 |
| MCM2 | GeneProduct | ensembl:ENSPTRG00000015345 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4171 |
| ORC3 | GeneProduct | ensembl:ENSPTRG00000018408 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23595 |
| CDKN2C | GeneProduct | ensembl:ENSPTRG00000000726 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1031 |
| POLE2 | GeneProduct | ensembl:ENSPTRG00000048697 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5427 |
| MNAT1 | GeneProduct | ensembl:ENSPTRG00000006412 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4331 |
| ORC6 | GeneProduct | ensembl:ENSPTRG00000008080 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23594 |
| CDK2 | GeneProduct | ensembl:ENSPTRG00000005070 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1017 |
| MCM5 | GeneProduct | ensembl:ENSPTRG00000014299 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4174 |
| E2F6 | GeneProduct | ensembl:ENSPTRG00000011661 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1876 |
| ORC2 | GeneProduct | ensembl:ENSPTRG00000012795 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4999 |
| E2F3 | GeneProduct | ensembl:ENSPTRG00000023584 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1871 |
| TFDP1 | GeneProduct | ensembl:ENSPTRG00000048704 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7027 |
| CDK6 | GeneProduct | ensembl:ENSPTRG00000019400 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1021 |
| RPA1 | GeneProduct | ensembl:ENSPTRG00000008539 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6117 |
| CREB1 | GeneProduct | ensembl:ENSPTRG00000043959 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1385 |
| RBL1 | GeneProduct | ensembl:ENSPTRG00000013469 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5933 |
| TFDP1 | GeneProduct | ensembl:ENSPTRG00000048704 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7027 |
| WEE1 | GeneProduct | ensembl:ENSPTRG00000003350 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7465 |
| ATM | GeneProduct | ensembl:ENSPTRG00000004250 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:472 |
| CREB3L1 | GeneProduct | ensembl:ENSPTRG00000003543 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:90993 |
| GADD45A | GeneProduct | ensembl:ENSPTRG00000000842 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1647 |
| POLA2 | GeneProduct | ensembl:ENSPTRG00000003870 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23649 |
| ORC4 | GeneProduct | ensembl:ENSPTRG00000012515 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5000 |
| CCNE1 | GeneProduct | ensembl:ENSPTRG00000010782 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:898 |
| PRIM1 | GeneProduct | ensembl:ENSPTRG00000022987 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5557 |
| CDC25A | GeneProduct | ensembl:ENSPTRG00000014879 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:993 |
| CCNE1 | GeneProduct | ensembl:ENSPTRG00000010782 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:898 |
| CCNA1 | GeneProduct | ensembl:ENSPTRG00000005784 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8900 |
| ORC5 | GeneProduct | ensembl:ENSPTRG00000019561 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5001 |
| CCNE2 | GeneProduct | ensembl:ENSPTRG00000020433 | Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9134 |
References
- GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia