Integrin-mediated cell adhesion (WP951)

Pan troglodytes

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: [[wikipedia:Integrins|Wikipedia]]

Authors

Thomas Kelder and Daniela Digles

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Pan troglodytes

Communities

Annotations

Pathway Ontology

integrin mediated signaling pathway

Participants

Label Type Compact URI Comment
CDC42 GeneProduct ncbigene:456609 CDC42; cell division cycle 42 (GTP binding protein 25kD)
SHC1 GeneProduct ncbigene:457351 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3 GeneProduct ncbigene:450176 SHC3; neuronal Sh
BRAF GeneProduct ncbigene:463781 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
RAF1 GeneProduct ncbigene:460182 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
MAPK7 GeneProduct ncbigene:454499 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
MYLK2 GeneProduct ncbigene:742591 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
ARHGEF7 GeneProduct ncbigene:452673 ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
RAC2 GeneProduct ncbigene:742575 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
VAV3 GeneProduct ncbigene:457076 VAV3; vav 3 oncogene
ROCK2 GeneProduct ncbigene:470307 ROCK2; Rho-associated coiled-coil containing protein kinase
ROCK1 GeneProduct ncbigene:455326 ROCK1; Rho-associated coiled-coil containing protein kinase
SORBS1 GeneProduct ncbigene:450628 SH3D5; SH3-domain protein 5 (ponsin
SOS1 GeneProduct ncbigene:459171 SOS1; son of sevenless homolog 1 (Drosophila)
GIT2 GeneProduct ncbigene:452227 GIT2; G protein-coupled receptor kinase-interactor 2
PIK3R2 GeneProduct ncbigene:455855 PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
CAV1 GeneProduct ncbigene:463670 CAV1; caveolin 1 caveolae protein 22kD
CAV2 GeneProduct ncbigene:494183 CAV2; caveolin 2
CAV3 GeneProduct ncbigene:738786 CAV3; caveolin 3
FYN GeneProduct ncbigene:462944 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
GRB2 GeneProduct ncbigene:737245 GRB2; growth factor receptor-bound protein 2
SEPP1 GeneProduct ncbigene:461897 SEPP1; selenoprotein P plasma
HRAS GeneProduct ncbigene:466302
PTK2 GeneProduct ncbigene:464422 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
RHO GeneProduct ncbigene:460685 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
CSK GeneProduct ncbigene:453745 CSK; c-src tyrosine kinase [EC:2.7.1.112]
BCAR1 GeneProduct ncbigene:454246 BCAR1; breast cancer anti-estrogen resistance 1
SRC GeneProduct ncbigene:458229 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
AKT1 GeneProduct ncbigene:740898 AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2 GeneProduct ncbigene:456035 AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
CAPN3 GeneProduct ncbigene:453363 CAPN3; calpain 3 (p94) [EC:3.4.22.17]
CAPN5 GeneProduct ncbigene:451438 CAPN5; calpain
CAPN7 GeneProduct ncbigene:460202 CAPN7; calpain 7 [EC:3.4.22.17
CAPN9 GeneProduct ncbigene:457812 CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
CAPN11 GeneProduct ncbigene:462727 CAPN11; calpain 11 [EC:3.4.22.17]
CAPN6 GeneProduct ncbigene:465810 CAPN6; calpain 6 [EC:3.4.22.17]
PAK2 GeneProduct ncbigene:460965 PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3 GeneProduct ncbigene:450118 PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
MAP2K3 GeneProduct ncbigene:454515 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K5 GeneProduct ncbigene:453532 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
MAP2K6 GeneProduct ncbigene:468310 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
AKT3 GeneProduct ncbigene:735718 AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
DOCK1 GeneProduct ncbigene:739420 DOCK1; dedicator of cyto-kinesis
CRK GeneProduct ncbigene:747142 CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
RAPGEF1 GeneProduct ncbigene:464812 GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RAP1A GeneProduct ncbigene:469408 RAP1A; RAP1A member of RAS oncogene family
RAP1B GeneProduct ncbigene:452065 RAP1B; RAP1B member of RAS oncogene family
MAPK1 GeneProduct ncbigene:458680 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK6 GeneProduct ncbigene:453439 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAP2K1 GeneProduct ncbigene:450188 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2 GeneProduct ncbigene:456390 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
CAPN1 GeneProduct ncbigene:451317 CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
ITGA2 GeneProduct ncbigene:471550
ITGA3 GeneProduct ncbigene:455111
ITGA4 GeneProduct ncbigene:470596
ITGA5 GeneProduct ncbigene:451958
ITGA6 GeneProduct ncbigene:459742
ITGA8 GeneProduct ncbigene:450323
ITGA9 GeneProduct ncbigene:470789
ITGA10 GeneProduct ncbigene:457982
ITGA11 GeneProduct ncbigene:453537
ITGA2B GeneProduct ncbigene:454730
ITGAD GeneProduct ncbigene:468103
ITGAL GeneProduct ncbigene:454045
ITGAM GeneProduct ncbigene:454069
ITGAV GeneProduct ncbigene:459807
ITGAX GeneProduct ncbigene:454070
ITGB1 GeneProduct ncbigene:450396
ITGB2 GeneProduct ncbigene:458607
ITGB3 GeneProduct ncbigene:468295
ITGB4 GeneProduct ncbigene:454887
ITGB5 GeneProduct ncbigene:460646
ITGB6 GeneProduct ncbigene:459683
ITGB7 GeneProduct ncbigene:451934
ITGB8 GeneProduct ncbigene:463282
VCL GeneProduct ncbigene:450531 VCL; vinculin
TNS1 GeneProduct ncbigene:459934 TNS; tensi
MAPK10 GeneProduct ncbigene:461358
PXN GeneProduct ncbigene:452303 PXN; paxillin
ILK GeneProduct ncbigene:748941 ILK; integrin-linked kinase [EC:2.7.1.-]
PAK1 GeneProduct ncbigene:451439 PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
VASP GeneProduct ncbigene:468919 VASP; vasodilator-stimulated phosphoprotein
ITGA7 GeneProduct ncbigene:451967
ITGA1 GeneProduct ncbigene:461880

References

  1. Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia