EPO receptor signaling (WP878)
Pan troglodytes
The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia This pathway is based on ScienceSlides.
Authors
Thomas Kelder , Christine Chichester , Eric Weitz , and Kristina HanspersActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Pan troglodytesCommunities
Annotations
Pathway Ontology
erythropoietin signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| EPOR | GeneProduct | ncbigene:455728 | |
| JAK2 | GeneProduct | ncbigene:464979 | |
| SRC | GeneProduct | ncbigene:458229 | |
| PIK3CG | GeneProduct | ncbigene:463649 | |
| GRB2 | GeneProduct | ncbigene:737245 |
References
- The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
- The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia