EPO receptor signaling (WP878)

Pan troglodytes

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The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.

Authors

Thomas Kelder , Christine Chichester , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Pan troglodytes

Communities

Annotations

Pathway Ontology

erythropoietin signaling pathway

Participants

Label Type Compact URI Comment
EPOR GeneProduct ncbigene:455728
JAK2 GeneProduct ncbigene:464979
SRC GeneProduct ncbigene:458229
STAT1 GeneProduct ncbigene:459834
SHC1 GeneProduct ncbigene:457351
GRB2 GeneProduct ncbigene:737245
MAP2K1 GeneProduct ncbigene:450188
MAPK3 GeneProduct ncbigene:454037
MAPK1 GeneProduct ncbigene:458680
MAP2K2 GeneProduct ncbigene:456390
PDK1 GeneProduct ncbigene:459743
AKT1 GeneProduct ncbigene:740898
PIK3CG GeneProduct ncbigene:463649
EPO GeneProduct ncbigene:463609
SOCS1 GeneProduct ncbigene:737070
STAT5B GeneProduct ncbigene:454679
CISH GeneProduct ncbigene:470819
STAT5A GeneProduct ncbigene:454681
STAT3 GeneProduct ncbigene:454682
PTPRC GeneProduct ncbigene:457607
PTPRU GeneProduct ncbigene:456692
RAF1 GeneProduct ncbigene:460182
SOS1 GeneProduct ncbigene:459171
IRS2 GeneProduct ncbigene:452657
IRS1 GeneProduct ncbigene:459985
RASA1 GeneProduct ncbigene:461762

References

  1. The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
  2. The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia