Eicosanoid synthesis (WP854)

Pan troglodytes

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]]

Authors

Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Pan troglodytes

Communities

Annotations

Pathway Ontology

eicosanoid biosynthetic pathway

Participants

Label Type Compact URI Comment
5-HPETE Metabolite hmdb:HMDB0001193
Prostaglandin H2 Metabolite hmdb:HMDB0001381
Leukotriene D4 Metabolite hmdb:HMDB0003080
Thromboxane B2 Metabolite hmdb:HMDB0003252
Prostaglandin I2 Metabolite hmdb:HMDB0001335
Prostaglandin D2 Metabolite hmdb:HMDB0001403
Leukotriene A4 Metabolite hmdb:HMDB0001337
Prostaglandin F2a Metabolite hmdb:HMDB0001139
Leukotriene C4 Metabolite hmdb:HMDB0001198
Leukotriene E4 Metabolite hmdb:HMDB0002200
Thromboxane A2 Metabolite hmdb:HMDB0001452
Arachidonic acid Metabolite hmdb:HMDB0001043
Leukotriene B4 Metabolite hmdb:HMDB0001085
ALOX5AP GeneProduct ncbigene:452520
PTGDS GeneProduct ncbigene:749402
PTGES2 GeneProduct ncbigene:464763
PTGIS GeneProduct ncbigene:458323
PLA2G2A GeneProduct ncbigene:456587
ALOX5 GeneProduct ncbigene:450428
TBXAS1 GeneProduct ncbigene:463774
PTGS1 GeneProduct ncbigene:464713
GGT1 GeneProduct ncbigene:470168
ALOX15 GeneProduct ncbigene:748294
ALOX15B GeneProduct ncbigene:455104
PTGES GeneProduct ncbigene:473071
LTA4H GeneProduct ncbigene:452145
PTGS2 GeneProduct ncbigene:469616
LTC4S GeneProduct ncbigene:739986
PNPLA8 GeneProduct ncbigene:472484
ALOX12 GeneProduct ncbigene:455242

References

  1. Prostaglandins and leukotrienes: advances in eicosanoid biology. Funk CD. Science. 2001 Nov 30;294(5548):1871–5. PubMed Europe PMC Scholia