Matrix metalloproteinases (WP823)

Gallus gallus

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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: Wikipedia

Authors

Thomas Kelder , Daniela Digles , Eric Weitz , and Kristina Hanspers

Activity

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Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

cell-extracellular matrix signaling pathway

Participants

Label Type Compact URI Comment
MMP23B GeneProduct ncbigene:419407
MMP27 GeneProduct ncbigene:395850
MMP2 GeneProduct ncbigene:386583
MMP11 GeneProduct ncbigene:769489
MMP15 GeneProduct ncbigene:415629
MMP9 GeneProduct ncbigene:395387
MMP3 GeneProduct ncbigene:418981
MMP28 GeneProduct ncbigene:417523
TIMP2 GeneProduct ncbigene:374178
MMP7 GeneProduct ncbigene:418983
MMP17 GeneProduct ncbigene:416801
BSG GeneProduct ncbigene:770363
MMP16 GeneProduct ncbigene:396116
TCF20 GeneProduct ncbigene:417980
MMP14 GeneProduct ncbigene:426253
MMP13 GeneProduct ncbigene:772008
TIMP3 GeneProduct ncbigene:396483
MMP24 GeneProduct ncbigene:419141
MMP1 GeneProduct ncbigene:418982
TIMP4 GeneProduct ncbigene:768711

References

  1. Matrix metalloproteinases: effectors of development and normal physiology. Vu TH, Werb Z. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia