Hedgehog signaling pathway (WP790)

Gallus gallus

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The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10

Authors

Alex Pico , Christine Chichester , and Eric Weitz

Activity

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Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

Hedgehog signaling pathway

Participants

Label Type Compact URI Comment
PTCH2 GeneProduct ncbigene:374187
SHH GeneProduct ncbigene:395615
CDC2 GeneProduct ncbigene:396252
PTCH1 GeneProduct ncbigene:395806
SMO GeneProduct ncbigene:395949
IHH GeneProduct ncbigene:395801
GLI3 GeneProduct ncbigene:420769
SKI GeneProduct ncbigene:428181
SUFU GeneProduct ncbigene:374118
SAP18 GeneProduct ncbigene:374206
SIN3A GeneProduct ncbigene:415307
GLI1 GeneProduct ncbigene:396045
CREBBP GeneProduct ncbigene:416667
DYRK1A GeneProduct ncbigene:395233
GLI2 GeneProduct ncbigene:395956
STK36 GeneProduct ncbigene:424210
RAB23 GeneProduct ncbigene:421879
IGF2 GeneProduct ncbigene:395097
HHIP GeneProduct ncbigene:422460

References

  1. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Mohler J. Genetics. 1988 Dec;120(4):1061–72. PubMed Europe PMC Scholia
  2. The Hedgehog response network: sensors, switches, and routers. Lum L, Beachy PA. Science. 2004 Jun 18;304(5678):1755–9. PubMed Europe PMC Scholia