EPO receptor signaling (WP768)

Gallus gallus

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The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.

Authors

Thomas Kelder , Christine Chichester , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

erythropoietin signaling pathway

Participants

Label Type Compact URI Comment
JAK2 GeneProduct ncbigene:374199
SRC GeneProduct ncbigene:396442
RCJMB04_17i9 GeneProduct ncbigene:424044
SHC1 GeneProduct ncbigene:395934
GRB2 GeneProduct ncbigene:386572
MAP2K1 GeneProduct ncbigene:415549
MAPK1 GeneProduct ncbigene:373953
MAP2K2 GeneProduct ncbigene:396349
RCJMB04_4o20 GeneProduct ncbigene:425972
AKT1 GeneProduct ncbigene:395928
PIK3CG GeneProduct ncbigene:417706
SOCS1 GeneProduct ncbigene:416630
STAT5B GeneProduct ncbigene:395556
CISH GeneProduct ncbigene:395335
STAT3 GeneProduct ncbigene:420027
PTPRC GeneProduct ncbigene:386580
PTPRU GeneProduct ncbigene:395153
RAF1 GeneProduct ncbigene:396245
SOS1 GeneProduct ncbigene:425964
IRS2 GeneProduct ncbigene:428017
IRS1 GeneProduct ncbigene:429126
RASA1 GeneProduct ncbigene:427327

References

  1. The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
  2. The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia