NSAIDs mechanism of action (WP5513)

Homo sapiens

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
"Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the cyclooxygenase isoenzymes COX1 and COX2 with varying degrees of specificity for the COX2 isoform. As a result, the conversion of arachidonic acid to prostaglandins (PGs) is inhibited. The main effects of PGs throughout the body are listed." Inspired by Figure 1 in PMID:32322101.

Authors

Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

drug pathway

Participants

Label Type Compact URI Comment
Diclofenac Metabolite drugbank:DB00586
PGD2 Metabolite chebi:15555
PGE2 Metabolite chebi:15551
PGF2a Metabolite chebi:15553
PGI2 Metabolite chebi:15552
PGG2 Metabolite chebi:27647
PGH2 Metabolite chebi:15554
PGA1 Metabolite chebi:15545
PGE1 Metabolite chebi:15544
Ibuprofen Metabolite drugbank:DB01050
Naproxen Metabolite drugbank:DB00788
Celecoxib Metabolite drugbank:DB00482
Rofecoxib Metabolite drugbank:DB00533

References

  1. Cardiovascular effects and safety of (non-aspirin) NSAIDs. Schjerning AM, McGettigan P, Gislason G. Nat Rev Cardiol. 2020 Sep;17(9):574–84. PubMed Europe PMC Scholia