Albuterol and budesonide therapy for asthma (WP5503)

Homo sapiens

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"A model for the molecular synergy between β2-agonists and GCs in modulating airway inflammation and bronchoconstriction in asthma. Glucocorticoids mediate their cellular responses by activating cytosolic GRα or mGR. The genomic effects of GCs modulate gene expression, which can typically take hours to occur. In contrast, GCs can also have nongenomic effects, which occur immediately or within minutes. GCs can also enhance cAMP generation induced by β2-agonists that can then inhibit a variety of procontractile signaling events to reverse bronchoconstriction." From Figure 1 in https://www.sciencedirect.com/science/article/pii/S2213219824001454.

Authors

Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

asthma

Cell Type Ontology

bronchial smooth muscle cell

Pathway Ontology

drug pathway asthma pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
cAMP Metabolite chebi:17489
Albuterol Metabolite chebi:2549
Budesonide Metabolite chebi:3207
ATP Metabolite chebi:15422
ADRB2 GeneProduct ensembl:ENSG00000169252
MYL1 GeneProduct ensembl:ENSG00000168530
MYL2 GeneProduct ensembl:ENSG00000111245
MYL3 GeneProduct ensembl:ENSG00000160808
MYL4 GeneProduct ensembl:ENSG00000198336
PLCB1 GeneProduct ensembl:ENSG00000182621
PLCB2 GeneProduct ensembl:ENSG00000137841
ADCY1 GeneProduct ensembl:ENSG00000164742
NR3C1 GeneProduct ensembl:ENSG00000113580
CREB1 GeneProduct ensembl:ENSG00000118260
ADCY2 GeneProduct ensembl:ENSG00000078295
ADCY3 GeneProduct ensembl:ENSG00000138031
ADCY4 GeneProduct ensembl:ENSG00000129467
ADCY5 GeneProduct ensembl:ENSG00000173175
ADCY6 GeneProduct ensembl:ENSG00000174233
ADCY7 GeneProduct ensembl:ENSG00000121281
ADCY8 GeneProduct ensembl:ENSG00000155897
ADCY9 GeneProduct ensembl:ENSG00000162104
PRKACA GeneProduct ensembl:ENSG00000288516
PRKACB GeneProduct ensembl:ENSG00000142875
PRKAR1A GeneProduct ensembl:ENSG00000108946
PRKAR2B GeneProduct ensembl:ENSG00000188191
PRKACA GeneProduct ensembl:ENSG00000072062
PRKAR2A GeneProduct ensembl:ENSG00000114302
PRKAR1B GeneProduct ensembl:ENSG00000188191
PLCB3 GeneProduct ensembl:ENSG00000149782
PLCB4 GeneProduct ensembl:ENSG00000101333
GNAS GeneProduct ensembl:ENSG00000087460

References

  1. The Use of Albuterol/Budesonide as Reliever Therapy to Reduce Asthma Exacerbations. Panettieri RA Jr, Chipps BE, Skolnik N, George M, Murphy K, Lugogo N. J Allergy Clin Immunol Pract. 2024 Apr;12(4):882–8. PubMed Europe PMC Scholia