Metabolism of T-2 toxin and HT-2 toxin (WP5425)

Triticum aestivum

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The T-2 (also T2) toxin is a cause of food poisoning. Metabolisation to HT-2 is reported as a detoxification mechanism in mammals. This pathway describes the mycotoxin metabolism pathway of T-2 in wheat with putative biotransformation products. Compounds were converted into identifiers using the 2D drawings in Figure 4 from Nathanail et al. 2015. Structure elucidation is detailed in Meng-Reiterer et al. 2015.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Egon Willighagen , Eric Weitz , Javier Millán Acosta , and Daniela Digles

Activity

last edited

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Organisms

Triticum aestivum

Communities

Annotations

Pathway Ontology

toxic secondary metabolite metabolic pathway

Participants

Label Type Compact URI Comment
T-2 toxin Metabolite chebi:9381
HT-2 toxin Metabolite chebi:138861
3-acetyl-T2 Metabolite pubchem.compound:49796734
3-trans-feruloyl-T2 Metabolite pubchem.compound:165362807
3-trans-isoferuloyl-T2 Metabolite wikidata:Q125535949
HT2-3-glucoside Metabolite wikidata:Q125536588
15-acetyl-T2-tretraol-3-glucoside Metabolite wikidata:Q125536699
T2-triol-3-glucoside Metabolite wikidata:Q125536589
3'hydroxy-HT2-3-glucoside Metabolite wikidata:Q125536590
dehydro-HT2-3-glucoside Metabolite wikidata:Q125536591
HT2-3-di-(1,6)-glucoside Metabolite wikidata:Q125536762
HT2-3-di-(1,4)-glucoside Metabolite wikidata:Q125536763
HT2-3-malonyl-glucoside Metabolite wikidata:Q125536677
3'hydroxy-HT2-3-malonyl-glucoside Metabolite wikidata:Q125536679

References

  1. Metabolism of the Fusarium Mycotoxins T-2 Toxin and HT-2 Toxin in Wheat. Nathanail AV, Varga E, Meng-Reiterer J, Bueschl C, Michlmayr H, Malachova A, et al. J Agric Food Chem. 2015 Sep 9;63(35):7862–72. PubMed Europe PMC Scholia
  2. Tracing the metabolism of HT-2 toxin and T-2 toxin in barley by isotope-assisted untargeted screening and quantitative LC-HRMS analysis. Meng-Reiterer J, Varga E, Nathanail AV, Bueschl C, Rechthaler J, McCormick SP, et al. Anal Bioanal Chem. 2015 Oct;407(26):8019–33. PubMed Europe PMC Scholia
  3. Metabolism of HT-2 Toxin and T-2 Toxin in Oats. Meng-Reiterer J, Bueschl C, Rechthaler J, Berthiller F, Lemmens M, Schuhmacher R. Toxins (Basel). 2016 Dec 5;8(12):364. PubMed Europe PMC Scholia