Phosphatidyl inositol phosphate pathway (WP5411)

Homo sapiens

New PIP pathway

Authors

Conroy lipids and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

phosphoinositide metabolic pathway glycerophospholipid metabolic pathway phosphatidylcholine metabolic pathway

Participants

Label Type Compact URI Comment
PIP2[3'4'] Metabolite lipidmaps:LMGP08010006
PIP[5'] Metabolite lipidmaps:LMGP070100B0
DG Metabolite lipidmaps:LMGL02010000
PIP[3'] Metabolite lipidmaps:LMGP07010000
PIP2[3',5'] Metabolite lipidmaps:LMGP08010007
PIP3[3',4',5'] Metabolite lipidmaps:LMGP09010000
1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol)(PI) Metabolite lipidmaps:LMGP06010000
PIP2[4',5'] Metabolite lipidmaps:LMGP08010005
PIP[4'] Metabolite lipidmaps:LMGP070100A0
PLCB1 GeneProduct uniprot:Q9NQ66
TPTE2 GeneProduct uniprot:Q6XPS3
INPP5K GeneProduct uniprot:Q9BT40
PI4KA GeneProduct uniprot:P42356
INPP4B GeneProduct uniprot:O15327
MTM1 GeneProduct uniprot:Q13496
MTMR1 GeneProduct uniprot:Q13613
PLCB3 GeneProduct uniprot:Q01970
PIP5K1B GeneProduct uniprot:O14986
MTMR6 GeneProduct uniprot:Q9Y217
PLCE1 GeneProduct uniprot:Q9P212
PLCG1 GeneProduct uniprot:P19174
PIK3C3 GeneProduct uniprot:P42338
PIP4K2C GeneProduct uniprot:Q8TBX8
INPP5D GeneProduct uniprot:Q92835
PI4K2B GeneProduct uniprot:Q8TCG2
MTMR8 GeneProduct uniprot:Q96EF0
PIK3C2A GeneProduct uniprot:O00443
PLCB4 GeneProduct uniprot:Q15147
PLCD4 GeneProduct uniprot:Q9BRC7
PIP4P2 GeneProduct uniprot:Q8N4L2
PIKFYVE GeneProduct uniprot:Q9Y2I7
PIP4P1 GeneProduct uniprot:Q86T03
PLCB2 GeneProduct uniprot:Q00722
PLCG2 GeneProduct uniprot:P16885
PIK3C2G GeneProduct uniprot:O75747
MTMR2 GeneProduct uniprot:Q13614
PLCD3 GeneProduct uniprot:Q8N3E9
PIP4K2B GeneProduct uniprot:P78356
PIK3C2B GeneProduct uniprot:O00750
PIP4K2A GeneProduct uniprot:P48426
SACM1L GeneProduct uniprot:Q9NTJ5
PI4K2A GeneProduct uniprot:Q9BTU6
PLCD1 GeneProduct uniprot:P51178
INPP4A GeneProduct uniprot:Q96PE3
PTEN GeneProduct uniprot:P60484
PI4KB GeneProduct uniprot:Q9UBF8
FIG4 GeneProduct uniprot:Q92562
PIP5K1C GeneProduct uniprot:O60331
OCRL GeneProduct uniprot:Q01968
INPP5E GeneProduct uniprot:Q9NRR6
IPMK Protein uniprot:Q8NFU5
PIP5K1A Protein uniprot:Q99755
PIK3CG Protein uniprot:P48736
PIK3CA Protein uniprot:P42336
PIK3CB Protein uniprot:P42338
PIK3CD Protein uniprot:O00329

References

  1. Glycerophospholipid synthesis: improved general method and new analogs containing photoactivable groups. Gupta CM, Radhakrishnan R, Khorana HG. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4315–9. PubMed Europe PMC Scholia
  2. Glycerophospholipid metabolism: back to the future. Holmsen H, Hindenes JO, Fukami M. Thromb Res. 1992 Aug 1;67(3):313–23. PubMed Europe PMC Scholia
  3. Occurrence and functions of the phosphatidylinositol cycle in the myocardium. Lamers JM, Dekkers DH, Bezstarosti K, Meij JT, van Heugten HA. Mol Cell Biochem. 1992 Oct 21;116(1–2):59–67. PubMed Europe PMC Scholia
  4. Structure, biosynthesis, and function of glycosylphosphatidylinositols. Thomas JR, Dwek RA, Rademacher TW. Biochemistry. 1990 Jun 12;29(23):5413–22. PubMed Europe PMC Scholia
  5. Inositol lipids and phosphates. Downes CP, Carter AN. Curr Opin Cell Biol. 1990 Apr;2(2):185–91. PubMed Europe PMC Scholia
  6. The metabolism of glycerophospholipid and its regulation in monocytes and macrophages. Nakagawa Y, Waku K. Prog Lipid Res. 1989;28(3):205–43. PubMed Europe PMC Scholia
  7. Phosphatidylinositol turnover in receptor mechanism and signal transduction. Hirasawa K, Nishizuka Y. Annu Rev Pharmacol Toxicol. 1985;25:147–70. PubMed Europe PMC Scholia
  8. Glycerophospholipid metabolism in neuronal and glial cell-enriched fractions. Arienti G, Goracci G, Porcellati G. Neurochem Res. 1981 Jul;6(7):729–42. PubMed Europe PMC Scholia
  9. Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation. Takenawa T, Itoh T, Fukami K. Chem Phys Lipids. 1999 Apr;98(1–2):13–22. PubMed Europe PMC Scholia
  10. PIP3, PIP2, and cell movement--similar messages, different meanings? Insall RH, Weiner OD. Dev Cell. 2001 Dec;1(6):743–7. PubMed Europe PMC Scholia
  11. Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Suh BC, Hille B. Curr Opin Neurobiol. 2005 Jun;15(3):370–8. PubMed Europe PMC Scholia
  12. Target-specific PIP(2) signalling: how might it work? Gamper N, Shapiro MS. J Physiol. 2007 Aug 1;582(Pt 3):967–75. PubMed Europe PMC Scholia
  13. Complex roles of PIP2 in the regulation of ion channels and transporters. Huang CL. Am J Physiol Renal Physiol. 2007 Dec;293(6):F1761-5. PubMed Europe PMC Scholia
  14. Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle. Large WA, Saleh SN, Albert AP. Cell Calcium. 2009 Jun;45(6):574–82. PubMed Europe PMC Scholia
  15. Lipid kinases: charging PtdIns(4,5)P2 synthesis. Divecha N. Curr Biol. 2010 Feb 23;20(4):R154-7. PubMed Europe PMC Scholia
  16. One lipid, multiple functions: how various pools of PI(4,5)P(2) are created in the plasma membrane. Kwiatkowska K. Cell Mol Life Sci. 2010 Dec;67(23):3927–46. PubMed Europe PMC Scholia
  17. Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton. Zhang L, Mao YS, Janmey PA, Yin HL. Subcell Biochem. 2012;59:177–215. PubMed Europe PMC Scholia
  18. Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: convergences and divergences among eukaryotic kingdoms. Delage E, Puyaubert J, Zachowski A, Ruelland E. Prog Lipid Res. 2013 Jan;52(1):1–14. PubMed Europe PMC Scholia