Phosphatidyl inositol phosphate pathway (WP5411)
Homo sapiens
New PIP pathway
Authors
Conroy lipids and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
phosphoinositide metabolic pathway glycerophospholipid metabolic pathway phosphatidylcholine metabolic pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
PIP2[3'4'] | Metabolite | lipidmaps:LMGP08010006 | |
PIP[5'] | Metabolite | lipidmaps:LMGP070100B0 | |
DG | Metabolite | lipidmaps:LMGL02010000 | |
PIP[3'] | Metabolite | lipidmaps:LMGP07010000 | |
PIP2[3',5'] | Metabolite | lipidmaps:LMGP08010007 | |
PIP3[3',4',5'] | Metabolite | lipidmaps:LMGP09010000 | |
1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol)(PI) | Metabolite | lipidmaps:LMGP06010000 | |
PIP2[4',5'] | Metabolite | lipidmaps:LMGP08010005 | |
PIP[4'] | Metabolite | lipidmaps:LMGP070100A0 | |
PLCB1 | GeneProduct | uniprot:Q9NQ66 | |
TPTE2 | GeneProduct | uniprot:Q6XPS3 | |
INPP5K | GeneProduct | uniprot:Q9BT40 | |
PI4KA | GeneProduct | uniprot:P42356 | |
INPP4B | GeneProduct | uniprot:O15327 | |
MTM1 | GeneProduct | uniprot:Q13496 | |
MTMR1 | GeneProduct | uniprot:Q13613 | |
PLCB3 | GeneProduct | uniprot:Q01970 | |
PIP5K1B | GeneProduct | uniprot:O14986 | |
MTMR6 | GeneProduct | uniprot:Q9Y217 | |
PLCE1 | GeneProduct | uniprot:Q9P212 | |
PLCG1 | GeneProduct | uniprot:P19174 | |
PIK3C3 | GeneProduct | uniprot:P42338 | |
PIP4K2C | GeneProduct | uniprot:Q8TBX8 | |
INPP5D | GeneProduct | uniprot:Q92835 | |
PI4K2B | GeneProduct | uniprot:Q8TCG2 | |
MTMR8 | GeneProduct | uniprot:Q96EF0 | |
PIK3C2A | GeneProduct | uniprot:O00443 | |
PLCB4 | GeneProduct | uniprot:Q15147 | |
PLCD4 | GeneProduct | uniprot:Q9BRC7 | |
PIP4P2 | GeneProduct | uniprot:Q8N4L2 | |
PIKFYVE | GeneProduct | uniprot:Q9Y2I7 | |
PIP4P1 | GeneProduct | uniprot:Q86T03 | |
PLCB2 | GeneProduct | uniprot:Q00722 | |
PLCG2 | GeneProduct | uniprot:P16885 | |
PIK3C2G | GeneProduct | uniprot:O75747 | |
MTMR2 | GeneProduct | uniprot:Q13614 | |
PLCD3 | GeneProduct | uniprot:Q8N3E9 | |
PIP4K2B | GeneProduct | uniprot:P78356 | |
PIK3C2B | GeneProduct | uniprot:O00750 | |
PIP4K2A | GeneProduct | uniprot:P48426 | |
SACM1L | GeneProduct | uniprot:Q9NTJ5 | |
PI4K2A | GeneProduct | uniprot:Q9BTU6 | |
PLCD1 | GeneProduct | uniprot:P51178 | |
INPP4A | GeneProduct | uniprot:Q96PE3 | |
PTEN | GeneProduct | uniprot:P60484 | |
PI4KB | GeneProduct | uniprot:Q9UBF8 | |
FIG4 | GeneProduct | uniprot:Q92562 | |
PIP5K1C | GeneProduct | uniprot:O60331 | |
OCRL | GeneProduct | uniprot:Q01968 | |
INPP5E | GeneProduct | uniprot:Q9NRR6 | |
IPMK | Protein | uniprot:Q8NFU5 | |
PIP5K1A | Protein | uniprot:Q99755 | |
PIK3CG | Protein | uniprot:P48736 | |
PIK3CA | Protein | uniprot:P42336 | |
PIK3CB | Protein | uniprot:P42338 | |
PIK3CD | Protein | uniprot:O00329 |
References
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- Glycerophospholipid metabolism: back to the future. Holmsen H, Hindenes JO, Fukami M. Thromb Res. 1992 Aug 1;67(3):313–23. PubMed Europe PMC Scholia
- Occurrence and functions of the phosphatidylinositol cycle in the myocardium. Lamers JM, Dekkers DH, Bezstarosti K, Meij JT, van Heugten HA. Mol Cell Biochem. 1992 Oct 21;116(1–2):59–67. PubMed Europe PMC Scholia
- Structure, biosynthesis, and function of glycosylphosphatidylinositols. Thomas JR, Dwek RA, Rademacher TW. Biochemistry. 1990 Jun 12;29(23):5413–22. PubMed Europe PMC Scholia
- Inositol lipids and phosphates. Downes CP, Carter AN. Curr Opin Cell Biol. 1990 Apr;2(2):185–91. PubMed Europe PMC Scholia
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- Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation. Takenawa T, Itoh T, Fukami K. Chem Phys Lipids. 1999 Apr;98(1–2):13–22. PubMed Europe PMC Scholia
- PIP3, PIP2, and cell movement--similar messages, different meanings? Insall RH, Weiner OD. Dev Cell. 2001 Dec;1(6):743–7. PubMed Europe PMC Scholia
- Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Suh BC, Hille B. Curr Opin Neurobiol. 2005 Jun;15(3):370–8. PubMed Europe PMC Scholia
- Target-specific PIP(2) signalling: how might it work? Gamper N, Shapiro MS. J Physiol. 2007 Aug 1;582(Pt 3):967–75. PubMed Europe PMC Scholia
- Complex roles of PIP2 in the regulation of ion channels and transporters. Huang CL. Am J Physiol Renal Physiol. 2007 Dec;293(6):F1761-5. PubMed Europe PMC Scholia
- Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle. Large WA, Saleh SN, Albert AP. Cell Calcium. 2009 Jun;45(6):574–82. PubMed Europe PMC Scholia
- Lipid kinases: charging PtdIns(4,5)P2 synthesis. Divecha N. Curr Biol. 2010 Feb 23;20(4):R154-7. PubMed Europe PMC Scholia
- One lipid, multiple functions: how various pools of PI(4,5)P(2) are created in the plasma membrane. Kwiatkowska K. Cell Mol Life Sci. 2010 Dec;67(23):3927–46. PubMed Europe PMC Scholia
- Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton. Zhang L, Mao YS, Janmey PA, Yin HL. Subcell Biochem. 2012;59:177–215. PubMed Europe PMC Scholia
- Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: convergences and divergences among eukaryotic kingdoms. Delage E, Puyaubert J, Zachowski A, Ruelland E. Prog Lipid Res. 2013 Jan;52(1):1–14. PubMed Europe PMC Scholia