UDP-derived sugars synthesis in fibroblasts (WP5394)

Homo sapiens

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One of the main roles of fibroblasts is the secretion of the extracellular matrix components such as glycosaminoglycans (GAGs). This pathway describes the synthesis of GAGs precursors - five UDP-derived sugars (UDP-α-D-galactose, UDP-α-D-glucuronate, UDP-α-D-xylose, UDP-N-acetyl-α-D-galactosamine, UDP-N-α-alpha-D-glucosamine). It takes place in the cytosol, where it starts with the conversion of D-glucopyranose to D-glucopyranose 6-phosphate, after which it can either proceed via a shorter or a longer path. The shorter leads to the synthesis of UDP-α-D-galactose, UDP-α-D-glucuronate and UDP-α-D-xylose, while the longer leads to the synthesis of UDP-N-acetyl-α-D-galactosamine and UDP-N-acetyl-α-D-glucosamine. Some of the enzymes are missing in the pathway and can be a subject for future research. This pathway was created based on the pathway information from the MetaCyc database (see Bibliography).

Authors

Julia Błąd , Daniela Digles , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

nucleotide sugar metabolic pathway classic metabolic pathway

Cell Type Ontology

fibroblast

Participants
Query Drugst.One

Label Type Compact URI Comment
UDP-α-D-glucose Metabolite chebi:58885
UDP-α-D-galactose Metabolite chebi:66914
β-D-fructofuranose 6-phosphate Metabolite chebi:57634
N-acetyl-α-D-galactosamine 1-phosphate Metabolite chebi:61970
α-D-galactosamine 1-phosphate Metabolite chebi:142399
D-galactosamine 6-phosphate Metabolite chebi:71674
D-glucosamine 6-phosphate Metabolite chebi:58725
UDP-N-acetyl-α-D-galactosamine Metabolite chebi:67138
UDP-N-acetyl-α-D-glucosamine Metabolite chebi:57705
N-acetyl-α-D-glucosamine 1-phosphate Metabolite chebi:57776
N-acetyl-α-D-glucosamine 6-phosphate Metabolite chebi:57513
α-D-glucosamine 1-phosphate Metabolite chebi:58516
α-D-glucose 6-phosphate Metabolite chebi:58225
D-glucopyranose 6-phosphate Metabolite chebi:4170
D-glucopyranose Metabolite chebi:4167
UDP-α-D-xylose Metabolite chebi:57632
UDP-α-D-glucuronate Metabolite chebi:58052
UGDH GeneProduct ensembl:ENSG00000109814
GALE GeneProduct ensembl:ENSG00000117308
GPI GeneProduct ensembl:ENSG00000105220
HK3 GeneProduct ensembl:ENSG00000160883
UXS1 GeneProduct ensembl:ENSG00000115652
GCK GeneProduct ensembl:ENSG00000106633
HK2 GeneProduct ensembl:ENSG00000159399
PGM3 GeneProduct ensembl:ENSG00000013375
PGM1 GeneProduct ensembl:ENSG00000079739
HK1 GeneProduct ensembl:ENSG00000156515
GFPT1 GeneProduct ensembl:ENSG00000198380

References

  1. The MetaCyc database of metabolic pathways and enzymes - a 2019 update. Caspi R, Billington R, Keseler IM, Kothari A, Krummenacker M, Midford PE, et al. Nucleic Acids Res. 2020 Jan 8;48(D1):D445–53. PubMed Europe PMC Scholia
  2. Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles. Huang YF, Mizumoto S, Fujita M. Front Cell Dev Biol. 2021 Sep 6;9:709018. PubMed Europe PMC Scholia