Lac-Phe pathway (WP5240)

Mus musculus

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Mouse Lac-Phe pathway

Authors

Egon Willighagen and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

classic metabolic pathway signaling pathway

Disease Ontology

obesity

Participants

Label Type Compact URI Comment
L-phenylalanine Metabolite chebi:58095
(S)-lactate Metabolite chebi:16651
Lac-Phe Metabolite chebi:167456
ABCC5 GeneProduct uniprot:Q9R1X5
CNDP2 Protein uniprot:Q9D1A2

References

  1. N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids. Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, et al. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6601–6. PubMed Europe PMC Scholia
  2. An exercise-inducible metabolite that suppresses feeding and obesity. Li VL, He Y, Contrepois K, Liu H, Kim JT, Wiggenhorn AL, et al. Nature. 2022 Jun;606(7915):785–90. PubMed Europe PMC Scholia