Ulcerative colitis signaling (WP5174)

Homo sapiens

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Ulcerative colitis (UC) together with Crohn’s disease (CD) are both chronic inflammation disorders in the gastrointestinal (GI) tract, and subtypes of inflammatory bowel disease (IBD). This inflammatory response in the GI tract is a result of various environmental and genetic components, microorganisms, and an impaired immune system. Among those many factors, changes in the luminal environment of the colonic epithelial cells are crucial and remain to be precisely analyzed. This pathway only considered UC, in which certain pathogens are found in increased or decreased amounts, compared to healthy controls. In the upper section of the pathway, it is shown that the toll-like receptors (TLRs) recognized the components derived from microbes, such as flagellin, peptidoglycan (PGN), and lipopolysaccharide. As depicted on the left, also nucleotide-binding oligomerization domain (NOD) proteins, and antigen-presenting cells (APCs) recognized those microbial molecules. Activation of the TLR signaling pathway drives the upregulation of NF-kappa-B and its corresponding inflammation reaction. At the same time, the APC regulates the shift of naïve T-cells into effector T-cells and (Th2) and natural killer (NKT) T-cells. UC is mainly dominated by the Th2-type inflammation and the corresponding production of IL-4, IL-5, IL-13 and IL-10.

Authors

Susan M. Bachmann , Leonie Sieder , Ana Rodrigues , Myrte Van De Bergh , Eric Weitz , and Martina Summer-Kutmon

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

disease pathway

Disease Ontology

inflammatory bowel disease 26 ulcerative colitis

Participants
Query Drugst.One

Label Type Compact URI Comment
PGN Metabolite chebi:8005
MDP Metabolite wikidata:Q259464
TNF-α GeneProduct ensembl:ENSG00000232810
MHCII GeneProduct ensembl:ENSG00000204257
NFKB1 GeneProduct ensembl:ENSG00000109320
NOD2 GeneProduct ensembl:ENSG00000167207
TLR2 GeneProduct ensembl:ENSG00000137462
TGFB1 GeneProduct ensembl:ENSG00000105329
IL13 GeneProduct ensembl:ENSG00000169194
IL10 GeneProduct ensembl:ENSG00000136634
FOXP3 GeneProduct ensembl:ENSG00000049768
yc GeneProduct ensembl:ENSG00000147168
NF-kappa-B Protein uniprot:P19838
IL-10 Protein uniprot:P22301
NFATc1 Protein uniprot:O95644
STAT6 Protein uniprot:P42226
c-maf Protein uniprot:O75444
IL-13 Protein uniprot:P35225
IL-4R subunit alpha Protein uniprot:H3BRH7
IL-4 Protein uniprot:D4HNR6
IL-5 Protein uniprot:P05113
GATA-3 Protein uniprot:P23771
IL-4 Protein uniprot:P05112
IFN-y Protein uniprot:P01579

References

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