Ulcerative colitis signaling (WP5174)

Homo sapiens

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Ulcerative colitis (UC) together with Crohn’s disease (CD) are both chronic inflammation disorders in the gastrointestinal (GI) tract, and subtypes of inflammatory bowel disease (IBD). This inflammatory response in the GI tract is a result of various environmental and genetic components, microorganisms, and an impaired immune system. Among those many factors, changes in the luminal environment of the colonic epithelial cells are crucial and remain to be precisely analyzed. This pathway only considered UC, in which certain pathogens are found in increased or decreased amounts, compared to healthy controls. In the upper section of the pathway, it is shown that the toll-like receptors (TLRs) recognized the components derived from microbes, such as flagellin, peptidoglycan (PGN), and lipopolysaccharide. As depicted on the left, also nucleotide-binding oligomerization domain (NOD) proteins, and antigen-presenting cells (APCs) recognized those microbial molecules. Activation of the TLR signaling pathway drives the upregulation of NF-kappa-B and its corresponding inflammation reaction. At the same time, the APC regulates the shift of naïve T-cells into effector T-cells and (Th2) and natural killer (NKT) T-cells. UC is mainly dominated by the Th2-type inflammation and the corresponding production of IL-4, IL-5, IL-13 and IL-10.

Authors

Susan M. Bachmann , Leonie Sieder , Ana Rodrigues , Myrte Van De Bergh , Eric Weitz , and Martina Summer-Kutmon

Activity

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

ulcerative colitis inflammatory bowel disease 26 inflammatory bowel disease

Cell Type Ontology

regulatory T cell mature NK T cell T-helper 1 cell T-helper 2 cell

Pathway Ontology

disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PGN Metabolite chebi:8005
MDP Metabolite wikidata:Q259464
TNF GeneProduct ensembl:ENSG00000232810 'TNF-α' originally
MHCII GeneProduct ensembl:ENSG00000204257
NFKB1 GeneProduct ensembl:ENSG00000109320
NOD2 GeneProduct ensembl:ENSG00000167207
TLR2 GeneProduct ensembl:ENSG00000137462
TGFB1 GeneProduct ensembl:ENSG00000105329
IL13 GeneProduct ensembl:ENSG00000169194
IL10 GeneProduct ensembl:ENSG00000136634
FOXP3 GeneProduct ensembl:ENSG00000049768
IL2RG GeneProduct ensembl:ENSG00000147168 'yc' originally
NF-kappa-B Protein uniprot:P19838
IL10 Protein uniprot:P22301 'IL-10' originally
NFATC1 Protein uniprot:O95644 'NFATc1' originally
STAT6 Protein uniprot:P42226
MAF Protein uniprot:O75444 'c-maf' originally
IL13 Protein uniprot:P35225 'IL-13' originally
IL4R Protein uniprot:H3BRH7 'IL-4R subunit alpha' originally
IL4 Protein uniprot:D4HNR6
IL5 Protein uniprot:P05113 'IL-5' originally
GATA3 Protein uniprot:P23771 'GATA-3' originally
IL4 Protein uniprot:P05112 'IL-4' originally
IFNG Protein uniprot:P01579 'IFN-y' originally

References

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