SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome (WP5118)

Homo sapiens

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Role of cohesin subunits SMC1 and SMC3 during DNA damage response.

Authors

Alp Irkilmez , Eric Weitz , Lars Willighagen , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

Cornelia de Lange syndrome

Pathway Ontology

disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
SMC3 GeneProduct ensembl:ENSG00000108055
RAD21 GeneProduct ensembl:ENSG00000164754
SMC1A GeneProduct ensembl:ENSG00000072501
BRCA1 GeneProduct ensembl:ENSG00000012048
NBN GeneProduct ensembl:ENSG00000104320
MRE11 GeneProduct ensembl:ENSG00000020922
RAD50 GeneProduct ensembl:ENSG00000113522
ATM GeneProduct ensembl:ENSG00000149311
ATM GeneProduct ensembl:ENSG00000149311 While SMC1A is specifically phosphorylated by phosphorylated ATM, no information was found on if the same applies to SMC3.
PAXIP1 GeneProduct ensembl:ENSG00000157212
RAD18 GeneProduct ensembl:ENSG00000070950
MDC1 GeneProduct ensembl:ENSG00000137337

References

  1. Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis. Yi F, Wang Z, Liu J, Zhang Y, Wang Z, Xu H, et al. Int J Biol Sci. 2017 Sep 3;13(8):1092–9. PubMed Europe PMC Scholia
  2. The Emerging Role of Cohesin in the DNA Damage Response. Litwin I, Pilarczyk E, Wysocki R. Genes (Basel). 2018 Nov 28;9(12):581. PubMed Europe PMC Scholia