Na/K-ATPase/Src signaling (WP5051)

Mus musculus

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Na/K-ATPase/Src Signaling

Authors

Tianjiang , Eric Weitz , and Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

cell adhesion signaling pathway

Participants

Label Type Compact URI Comment
Tesk2 GeneProduct ncbigene:230661
Rac2 GeneProduct ncbigene:19354
Gsk3b GeneProduct ncbigene:56637
Atp1a1 GeneProduct ncbigene:11928
Birc4 GeneProduct ncbigene:11798
Txk GeneProduct ncbigene:22165
Fyn GeneProduct ncbigene:14360 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
Sos1 GeneProduct ncbigene:20662 SOS1; son of sevenless homolog 1 (Drosophila)
Rap1a GeneProduct ncbigene:109905 RAP1A; RAP1A member of RAS oncogene family
Cav3 GeneProduct ncbigene:12391 CAV3; caveolin 3
Kdr GeneProduct ncbigene:16542
Bad GeneProduct ncbigene:12015
Rac3 GeneProduct ncbigene:170758
Sepp1 GeneProduct ncbigene:20363 SEPP1; selenoprotein P plasma
Grb2 GeneProduct ncbigene:14784 GRB2; growth factor receptor-bound protein 2
Bcl2 GeneProduct ncbigene:12043
Raf1 GeneProduct mgi:MGI:97847 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
Met GeneProduct ncbigene:17295
Egfr GeneProduct ncbigene:13649
Mapk9 GeneProduct ncbigene:26420
Pik3r5 GeneProduct ncbigene:320207
Pak1 GeneProduct ncbigene:18479
Srms GeneProduct ncbigene:20811
Ilk GeneProduct ncbigene:16202 ILK; integrin-linked kinase [EC:2.7.1.-]
Pak3 GeneProduct ncbigene:18481
Birc3 GeneProduct ncbigene:11796
Rapgef1 GeneProduct ncbigene:107746
Mapk6 GeneProduct ncbigene:50772 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
Birc2 GeneProduct ncbigene:11797
Ctnnb1 GeneProduct ncbigene:12387
Styk1 GeneProduct ncbigene:243659
Dock1 GeneProduct mgi:MGI:2429765 DOCK1; dedicator of cyto-kinesis
Shc3 GeneProduct ncbigene:20418 SHC3; neuronal Sh
Araf GeneProduct ncbigene:11836 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
Crk GeneProduct ncbigene:12928
Map2k2 GeneProduct ncbigene:26396 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
Map2k3 GeneProduct ncbigene:26397 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
Pik3cg GeneProduct ncbigene:30955
Casp9 GeneProduct ncbigene:12371
Hras GeneProduct ncbigene:15461
Mtor GeneProduct ncbigene:56717
cyct GeneProduct ncbigene:13067
Braf GeneProduct ncbigene:109880 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
Mapk1 GeneProduct ncbigene:26413 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
Ccnd2 GeneProduct ncbigene:12444
cycs GeneProduct ncbigene:13063
Ptk2 GeneProduct ncbigene:14083 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
Vav1 GeneProduct ncbigene:22324
Akt3 GeneProduct ncbigene:23797
Pak7 GeneProduct ncbigene:241656
Tnk2 GeneProduct ncbigene:51789
Pdgfra GeneProduct ncbigene:18595
Ccnd3 GeneProduct ncbigene:12445
Atp1b1 GeneProduct ncbigene:11931
Map2k5 GeneProduct ncbigene:23938 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
Rap1b GeneProduct ncbigene:215449 RAP1B; RAP1B member of RAS oncogene family
Blk GeneProduct ncbigene:12143
Flt1 GeneProduct ncbigene:14254
Mapk8 GeneProduct ncbigene:26419
Rac1 GeneProduct ncbigene:19353
Ptk6 GeneProduct ncbigene:20459
Src GeneProduct ncbigene:20779 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
Pak2 GeneProduct ncbigene:224105
Tnk1 GeneProduct ncbigene:83813
Map2k6 GeneProduct ncbigene:26399 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
Pak6 GeneProduct ncbigene:214230
Mapk4 GeneProduct ncbigene:225724 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
Crk1 GeneProduct ncbigene:12929
Cav2 GeneProduct ncbigene:12390 CAV2; caveolin 2
Cav GeneProduct ncbigene:12389 CAV1; caveolin 1 caveolae protein 22kD
Shc1 GeneProduct ncbigene:20416 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
Pak4 GeneProduct ncbigene:70584
Apaf1 GeneProduct ncbigene:11783
Mapk7 GeneProduct ncbigene:23939 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
Akt1 GeneProduct ncbigene:11651
Pik3cb GeneProduct ncbigene:74769
Pik3cd GeneProduct ncbigene:18707
Erbb2 GeneProduct ncbigene:13866
Pdgfrb GeneProduct ncbigene:18596
Braf GeneProduct ncbigene:109880
Map2k1 GeneProduct ncbigene:26395 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
Ccnd1 GeneProduct ncbigene:12443
Igf1r GeneProduct ncbigene:16001
Pik3ca GeneProduct ncbigene:18706
Hck GeneProduct ncbigene:15162
Pten GeneProduct ncbigene:19211
Elk1 GeneProduct ncbigene:13712
Pik3r4 GeneProduct ncbigene:75669
Casp3 GeneProduct ncbigene:12367
Bcar1 GeneProduct ncbigene:12927
Akt2 GeneProduct ncbigene:11652
Pik3r1 GeneProduct ncbigene:18708
Pik3r2 GeneProduct ncbigene:18709
Jun GeneProduct ncbigene:16476
Mapk12 GeneProduct ncbigene:29857 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
Fgr GeneProduct ncbigene:14191

References

  1. The PI3K-PDK1 connection: more than just a road to PKB. Vanhaesebroeck B, Alessi DR. Biochem J. 2000 Mar 15;346 Pt 3(Pt 3):561–76. PubMed Europe PMC Scholia
  2. Rho GTPases: signaling, migration, and invasion. Schmitz AA, Govek EE, Böttner B, Van Aelst L. Exp Cell Res. 2000 Nov 25;261(1):1–12. PubMed Europe PMC Scholia
  3. Fibronectin, integrins, and growth control. Danen EH, Yamada KM. J Cell Physiol. 2001 Oct;189(1):1–13. PubMed Europe PMC Scholia
  4. The protein kinase B/Akt signalling pathway in human malignancy. Nicholson KM, Anderson NG. Cell Signal. 2002 May;14(5):381–95. PubMed Europe PMC Scholia
  5. Get a ligand, get a life: integrins, signaling and cell survival. Stupack DG, Cheresh DA. J Cell Sci. 2002 Oct 1;115(Pt 19):3729–38. PubMed Europe PMC Scholia
  6. Interactions between growth factor receptors and adhesion molecules: breaking the rules. Comoglio PM, Boccaccio C, Trusolino L. Curr Opin Cell Biol. 2003 Oct;15(5):565–71. PubMed Europe PMC Scholia
  7. Rho and Rac take center stage. Burridge K, Wennerberg K. Cell. 2004 Jan 23;116(2):167–79. PubMed Europe PMC Scholia
  8. Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function. Xie Z, Cai T. Mol Interv. 2003 May;3(3):157–68. PubMed Europe PMC Scholia
  9. The mechanism of action of the tumour suppressor gene PTEN. Hlobilková A, Knillová J, Bártek J, Lukás J, Kolár Z. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Nov;147(1):19–25. PubMed Europe PMC Scholia
  10. Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase. Oloumi A, McPhee T, Dedhar S. Biochim Biophys Acta. 2004 Apr 1;1691(1):1–15. PubMed Europe PMC Scholia
  11. Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways. Lee JW, Juliano R. Mol Cells. 2004 Apr 30;17(2):188–202. PubMed Europe PMC Scholia
  12. Binding of Src to Na+/K+-ATPase forms a functional signaling complex. Tian J, Cai T, Yuan Z, Wang H, Liu L, Haas M, et al. Mol Biol Cell. 2006 Jan;17(1):317–26. PubMed Europe PMC Scholia
  13. Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. Liu C, Bai Y, Chen Y, Wang Y, Sottejeau Y, Liu L, et al. J Biol Chem. 2012 May 11;287(20):16390–8. PubMed Europe PMC Scholia
  14. pNaKtide Attenuates Steatohepatitis and Atherosclerosis by Blocking Na/K-ATPase/ROS Amplification in C57Bl6 and ApoE Knockout Mice Fed a Western Diet. Sodhi K, Srikanthan K, Goguet-Rubio P, Nichols A, Mallick A, Nawab A, et al. Sci Rep. 2017 Mar 15;7(1):193. PubMed Europe PMC Scholia
  15. The Redox-Sensitive Na/K-ATPase Signaling in Uremic Cardiomyopathy. Liu J, Nie Y, Chaudhry M, Bai F, Chuang J, Sodhi K, et al. Int J Mol Sci. 2020 Feb 13;21(4):1256. PubMed Europe PMC Scholia
  16. Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop. Sodhi K, Denvir J, Liu J, Sanabria JR, Chen Y, Silverstein R, et al. Int J Mol Sci. 2020 Aug 18;21(16):5923. PubMed Europe PMC Scholia