Hypoxia-dependent proliferation of myoblasts (WP5024)

Mus musculus

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Molecular mechanisms involved in myogenic proliferation during hypoxia. Black arrow: activation of the signaling pathway/ protein/ molecule. Blunt red arrow: inhibition of the signaling pathway/protein/ molecule.

Authors

Maximilian Saller , Laurent Winckers , Lauren J. Dupuis , Eric Weitz , and Kristina Hanspers

Activity

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Cell Type Ontology

myoblast

Pathway Ontology

signaling pathway phosphatidylinositol 3-kinase-Akt signaling pathway

Participants

Label Type Compact URI Comment
VEGF GeneProduct ncbigene:22339
MSTN GeneProduct ncbigene:17700
Trim63 GeneProduct ncbigene:433766
MYOD1 GeneProduct ncbigene:17927
TSC2 GeneProduct ncbigene:22084
HGF GeneProduct ncbigene:15234
Fbxo32 GeneProduct ncbigene:67731
MYF5 GeneProduct ncbigene:17877
TSC1 GeneProduct ncbigene:64930
AKT GeneProduct ncbigene:11651
Smad3 GeneProduct ncbigene:17127
IGF1 GeneProduct ncbigene:16000
DDIT44 GeneProduct ncbigene:74747
RHEB GeneProduct ncbigene:19744
FGF GeneProduct ncbigene:14164
MTOR1 GeneProduct ncbigene:56717
Smad2 GeneProduct ncbigene:17126
MYOG GeneProduct ncbigene:17928
Calcitriol Protein uniprot:P70160

References

  1. Regulation of myostatin activity and muscle growth. Lee SJ, McPherron AC. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9306–11. PubMed Europe PMC Scholia
  2. Delayed object-quality discriminations in hemicerebrectomized monkeys. KRUPER DC, PATTON RA, KOSKOFF YD. J Comp Physiol Psychol. 1961 Dec;54:619–24. PubMed Europe PMC Scholia
  3. Cellular and molecular regulation of muscle regeneration. Chargé SBP, Rudnicki MA. Physiol Rev. 2004 Jan;84(1):209–38. PubMed Europe PMC Scholia
  4. The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, et al. Mol Cell. 2004 May 7;14(3):395–403. PubMed Europe PMC Scholia
  5. 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Garcia LA, King KK, Ferrini MG, Norris KC, Artaza JN. Endocrinology. 2011 Aug;152(8):2976–86. PubMed Europe PMC Scholia
  6. O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling. Majmundar AJ, Skuli N, Mesquita RC, Kim MN, Yodh AG, Nguyen-McCarty M, et al. Mol Cell Biol. 2012 Jan;32(1):36–49. PubMed Europe PMC Scholia
  7. Human exposure to tickborne relapsing fever spirochete Borrelia miyamotoi, the Netherlands. Fonville M, Friesema IHM, Hengeveld PD, Docters van Leeuwen A, Jahfari S, Harms MG, et al. Emerg Infect Dis. 2014 Jul;20(7):1244–5. PubMed Europe PMC Scholia
  8. Muscle atrophy reversed by growth factor activation of satellite cells in a mouse muscle atrophy model. Hauerslev S, Vissing J, Krag TO. PLoS One. 2014 Jun 25;9(6):e100594. PubMed Europe PMC Scholia
  9. Hypoxia Inhibits Myogenic Differentiation through p53 Protein-dependent Induction of Bhlhe40 Protein. Wang C, Liu W, Liu Z, Chen L, Liu X, Kuang S. J Biol Chem. 2015 Dec 11;290(50):29707–16. PubMed Europe PMC Scholia
  10. Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model. Zhang GW, Gu TX, Sun XJ, Wang C, Qi X, Wang XB, et al. J Thorac Cardiovasc Surg. 2016 Aug;152(2):570–82. PubMed Europe PMC Scholia