Alpha 6 beta 4 integrin signaling pathway (WP488)

Mus musculus

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Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands of the alpha6 beta4 integrin are heterotrimers belonging to the laminin family including Laminin A2, Laminin B1, Laminin C1, Laminin A3, Laminin B3, Laminin C2, Laminin A5, Laminin A1 and Laminin B2 among others. Upon activation, the receptor is phosphorylated and associates with adaptor molecules Shc and Grb2, which then activate the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_1

Authors

Akhilesh Pandey , Kristina Hanspers , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

integrin mediated signaling pathway

Participants

Label Type Compact URI Comment
Rhoa GeneProduct ncbigene:11848
Rtkn GeneProduct ncbigene:20166
Itgb4 GeneProduct ncbigene:192897
Fyn GeneProduct ncbigene:14360
Clca3 GeneProduct ncbigene:23844
Ptk2 GeneProduct ncbigene:14083
Itga6 GeneProduct ncbigene:16403
Rpsa GeneProduct ncbigene:16785
Vim GeneProduct ncbigene:22352
Clca5 GeneProduct ncbigene:229933
Grb2 GeneProduct ncbigene:14784
Dst GeneProduct ncbigene:13518
Erbb2ip GeneProduct ncbigene:59079
Erbb2 GeneProduct ncbigene:13866
Pik3r1 GeneProduct ncbigene:18708
Pik3r2 GeneProduct ncbigene:18709
Pik3r3 GeneProduct ncbigene:18710
Pik3ca GeneProduct ncbigene:18706
Pik3cb GeneProduct ncbigene:74769
Pik3cg GeneProduct ncbigene:30955
Pik3cd GeneProduct ncbigene:18707
Col17a1 GeneProduct ncbigene:12821
Shc1 GeneProduct ncbigene:20416
Mst1r GeneProduct ncbigene:19882
Sfn GeneProduct ncbigene:55948
Lama1 GeneProduct ncbigene:16772
Lamb1-1 GeneProduct ncbigene:16777
Lamc1 GeneProduct ncbigene:226519
Lama5 GeneProduct ncbigene:16776
Lamb2 GeneProduct ncbigene:16779
Lama2 GeneProduct ncbigene:16773
Lama3 GeneProduct ncbigene:16774
Lamb3 GeneProduct ncbigene:16780
Lamc2 GeneProduct ncbigene:16782
Pak1 GeneProduct ncbigene:18479
Rac1 GeneProduct ncbigene:19353
Plec1 GeneProduct ncbigene:18810
Cd151 GeneProduct ncbigene:12476
Irs2 GeneProduct ncbigene:384783
Irs1 GeneProduct ncbigene:16367
Egfr GeneProduct ncbigene:13649
Ar GeneProduct ncbigene:11835
Trp73 GeneProduct ncbigene:22062
Abl1 GeneProduct ncbigene:11350
Ywhab GeneProduct ncbigene:54401
Ywhae GeneProduct ncbigene:22627
Ywhah GeneProduct ncbigene:22629
Gm2423 GeneProduct ensembl:ENSMUSG00000061724
Ywhaz GeneProduct ncbigene:22631
Yes1 GeneProduct ncbigene:22612
Dsp GeneProduct ncbigene:109620
Met GeneProduct ncbigene:17295
Eif4ebp1 GeneProduct ncbigene:13685
Eif4e GeneProduct ncbigene:13684
Eif6 GeneProduct ncbigene:16418
Ntn1 GeneProduct ncbigene:18208
Akt1 GeneProduct ncbigene:11651
Casp3 GeneProduct ncbigene:12367
Bad GeneProduct ncbigene:12015
Prkca GeneProduct ncbigene:18750
Mtor GeneProduct ncbigene:56717
Prkcd GeneProduct ncbigene:18753
Mmp7 GeneProduct ncbigene:17393
Src GeneProduct ncbigene:20779
Smad2 GeneProduct ncbigene:17126
Smad3 GeneProduct ncbigene:17127
Cdkn1a GeneProduct ncbigene:12575

References