Glucosinolate biosynthesis (from aromatic amino acid) (WP4598)

Arabidopsis thaliana

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This pathway describes the glucosinolate derived from aromatic amino acid (Phe, Tyr, Trp) in Arabidopsis thaliana. This is based on the KEGG pathway and PlantCyc. Some pathway entities are unknown and being investigated, these are denoted as "Catalyst" and "Metabolite" for now.

Authors

Mikiko Takahashi , Atsushi Fukushima , and Kristina Hanspers

Activity

last edited

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Organisms

Arabidopsis thaliana

Communities

Annotations

Pathway Ontology

classic metabolic pathway

Participants

Label Type Compact URI Comment
L-Phenylalanine Metabolite kegg.compound:C00079
(E)-Phenylacetaldoxime Metabolite kegg.compound:C19714
S-(Phenylacetothiohydroximoyl)-L-cysteine Metabolite kegg.compound:C17237
Phenylacetothiohydroximate Metabolite kegg.compound:C03719
Desulfoglucotropeolin Metabolite kegg.compound:C01069
L-Tryptophan Metabolite kegg.compound:C00078
L-Tyrosine Metabolite kegg.compound:C00082
Benzyl glucosinolate Metabolite chebi:17127
Indole-3-acetaldehyde oxime Metabolite kegg.compound:C02937
S-(Indolylmethylthiohydroximoyl)-L-cysteine Metabolite kegg.compound:C16518
L-Homophenylalanine Metabolite kegg.compound:C17235
3-Phenylpropionaldoxim Metabolite kegg.compound:C17236
2-Phenylethyl glucosinolate Metabolite kegg.compound:C08417
Indolylmethylthiohydroximate Metabolite kegg.compound:C16516
Indolylmethyl-desulfoglucosinolate Metabolite kegg.compound:C16517
3-indolylmethyl glucosinolate Metabolite knapsack:C00000125
(E)-4-Hydroxyphenylacetaldehyde oxime Metabolite kegg.compound:C04350
S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine Metabolite kegg.compound:C17238
p-Hydroxyphenylacetothiohydroximate Metabolite kegg.compound:C17239
p-Hydroxybenzyldesulphoglucosinolate Metabolite kegg.compound:C17240
p-Hydroxybenzyl glucosinolate Metabolite kegg.compound:C08426
4-Hydroxy-3-indolylmethylglucosinolate Metabolite knapsack:C00000127
1-Hydroxy-3-indolylmethylglucosinolate Metabolite pubchem.compound:123131529
1-Methoxy-3-indolylmethylglucosinolate Metabolite knapsack:C00000126
4-Methoxy-3-indolylmethylglucosinolate Metabolite knapsack:C00000128
CYP79A2 GeneProduct tair.locus:AT5G05260
CYP83B1 GeneProduct tair.locus:AT4G31500
SUR1 GeneProduct :AT2G20610
UGT74B1 GeneProduct tair.locus:AT1G24100
SOT16 GeneProduct tair.locus:AT1G74100
CYP79A1 GeneProduct kegg.genes:K13027
CYP79B2 GeneProduct tair.locus:AT4G39950
CYP79B3 GeneProduct tair.locus:AT2G22330
SUR1 GeneProduct tair.locus:AT2G20610
UGT74B1 GeneProduct tair.locus:AT1G24100
SUR1 GeneProduct tair.locus:AT2G20610
CYP81F2 GeneProduct tair.locus:AT5G57220
CYP81F4 GeneProduct tair.locus:AT4G37410
O-methyltransferase GeneProduct tair.locus:IGMT5
CYP81F3 GeneProduct tair.locus:AT4G37400
CYP81F1 GeneProduct tair.locus:AT4G37430
indole glucosinolate methyltransferase GeneProduct tair.locus:IGMT1
CYP83B1 GeneProduct tair.locus:AT4G31500
CYP83B1 GeneProduct tair.locus:AT4G31500
SOT16 GeneProduct tair.locus:AT1G74100
SOT16 GeneProduct tair.locus:AT1G74100

References

  1. Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis. Grubb CD, Zipp BJ, Ludwig-Müller J, Masuno MN, Molinski TF, Abel S. Plant J. 2004 Dec;40(6):893–908. PubMed Europe PMC Scholia
  2. The three desulfoglucosinolate sulfotransferase proteins in Arabidopsis have different substrate specificities and are differentially expressed. Klein M, Reichelt M, Gershenzon J, Papenbrock J. FEBS J. 2006 Jan;273(1):122–36. PubMed Europe PMC Scholia
  3. Kinetics and substrate specificities of desulfo-glucosinolate sulfotransferases in Arabidopsis thaliana. Klein M, Papenbrock J. Physiol Plant. 2009 Feb;135(2):140–9. PubMed Europe PMC Scholia
  4. Glucosinolate breakdown in Arabidopsis: mechanism, regulation and biological significance. Wittstock U, Burow M. Arabidopsis Book. 2010;8:e0134. PubMed Europe PMC Scholia