Matrix metalloproteinases (WP441)

Mus musculus

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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: [[wikipedia:Matrix_metalloproteinase|Wikipedia]]

Authors

Kdahlquist , Meredith Braymer , Kristina Hanspers , Thomas Kelder , Daniela Digles , and Eric Weitz

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

cell-extracellular matrix signaling pathway

Participants

Label Type Compact URI Comment
Mmp2 GeneProduct ncbigene:17390
Mmp9 GeneProduct ncbigene:17395
Mmp7 GeneProduct ncbigene:17393
Mmp12 GeneProduct ncbigene:17381
Mmp20 GeneProduct ncbigene:30800
Mmp10 GeneProduct ncbigene:17384
Mmp3 GeneProduct ncbigene:17392
Mmp11 GeneProduct ncbigene:17385
Mmp19 GeneProduct ncbigene:58223
Mmp14 GeneProduct ncbigene:17387
Mmp15 GeneProduct ncbigene:17388
Mmp16 GeneProduct ncbigene:17389
Mmp17 GeneProduct ncbigene:23948
Mmp24 GeneProduct ncbigene:17391
Timp2 GeneProduct ncbigene:21858
Timp3 GeneProduct ncbigene:21859
Timp4 GeneProduct ncbigene:110595
Bsg GeneProduct ncbigene:12215
Tnf GeneProduct ncbigene:21926
Mmp28 GeneProduct ncbigene:118453
Mmp25 GeneProduct ncbigene:240047
Mmp27 GeneProduct ncbigene:234911
Tcf20 GeneProduct ncbigene:21411
Mmp21 GeneProduct ncbigene:214766
Mmp1a GeneProduct ncbigene:83995
Mmp8 GeneProduct ncbigene:17394
Mmp13 GeneProduct ncbigene:17386
Timp1 GeneProduct ncbigene:21857
Mmp23 GeneProduct ncbigene:26561

References

  1. Matrix metalloproteinases: effectors of development and normal physiology. Vu TH, Werb Z. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia