Biosynthesis of the three types of mycolic acids (WP4198)

Mycobacterium tuberculosis

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Pathway leading to the biosynthesis of the three types of mycolic acids in M. tuberculosis, as published in: "Virulence factors of the Mycobacterium tuberculosis complex" (PMID: 23076359)

Authors

Andra Waagmeester , Egon Willighagen , Eric Weitz , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Mycobacterium tuberculosis

Communities

Annotations

Pathway Ontology

classic metabolic pathway

Disease Ontology

tuberculosis

Participants

Label Type Compact URI Comment
Carbon dioxide Metabolite pubchem.compound:280
Malonyl-CoA Metabolite pubchem.compound:869
acetyl coenzyme a Metabolite pubchem.compound:444493
methoxy mycolic acid Metabolite chebi:59233
α-mycolic acid Metabolite chebi:59235
AcpM GeneProduct ncbigene:888272
InhA GeneProduct ncbigene:886523
FadD32 Protein uniprot:O53580
mtFabH Protein uniprot:P9WNG3
KasA Protein uniprot:A5U4S7
Rv0636 Protein uniprot:I6WYY7
Rv0635 Protein uniprot:I6Y8B9
Rv0637 Protein uniprot:I6Y4B3
Rv2425c Protein uniprot:P71923
KasB Protein uniprot:P9WQD6

References

  1. Virulence factors of the Mycobacterium tuberculosis complex. Forrellad MA, Klepp LI, Gioffré A, Sabio y García J, Morbidoni HR, de la Paz Santangelo M, et al. Virulence. 2013 Jan 1;4(1):3–66. PubMed Europe PMC Scholia