Model of Fgf and Wnt crosstalk in tailbud (WP4021)
Danio rerio
A simple model of the Fgf and Wnt gene network in the zebrafish tailbud. Fgf signaling inhibits transcription of the Wnt inhibitors dkk1 and notum1a. PI3k signaling activates the Wnt pathway by phosphorylating (inactivating) Gsk3β. Phosphorylation of Gsk3β also leads to an increase in active Erk levels, suggesting Wnt signaling promotes Mapk activity. Fgf and Wnt have opposing effects on transcription of co-regulated genes, which include Fgf (spred3) and Wnt (dkk1, notum1a) inhibitors. (From Stulberg et al)
Authors
Kristina HanspersActivity
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Organisms
Danio rerioCommunities
Annotations
Pathway Ontology
fibroblast growth factor signaling pathway Wnt signaling pathwayReferences
- Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud. Stulberg MJ, Lin A, Zhao H, Holley SA. Dev Biol. 2012 Sep 15;369(2):298–307. PubMed Europe PMC Scholia