IL-1 signaling pathway (WP37)

Mus musculus

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The interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor, IL1R2. Upon binding to the ligands, interleukin-1 alpha or beta, IL1R1 interacts with IL-1 receptor accessory protein (IL1RAP) to activate the MAPK/JNK signaling modules. The MAPK pathway leads to activation of NFkB complex. As both IL-1 and TNF alpha stimulate the MAPK signaling module and activate NFkB, they are synergistic and complement each other's activity. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_13

Authors

Akhilesh Pandey , Christine Chichester , Olivier Traets , and Eric Weitz

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

interleukin-1 signaling pathway

Participants

Label Type Compact URI Comment
Il1rap GeneProduct ncbigene:16180
Sirpa GeneProduct ncbigene:19261
PELI1 GeneProduct ncbigene:67245
Irak1 GeneProduct ncbigene:16179
Irak2 GeneProduct ncbigene:108960
MAPK1 GeneProduct ncbigene:26413
Irak4 GeneProduct ncbigene:266632
MAP3K14 GeneProduct ncbigene:53859
NFKBIA GeneProduct ncbigene:18035
MAP2K1 GeneProduct ncbigene:26395
CHUK GeneProduct ncbigene:12675
MAP3K7 GeneProduct ncbigene:26409
RELA GeneProduct ncbigene:19697
Il1b GeneProduct ensembl:ENSMUSG00000027398
Il1a GeneProduct ensembl:ENSMUSG00000027399
Traf6 GeneProduct ncbigene:22034
Il1r1 GeneProduct ncbigene:16177
Il1rn GeneProduct ncbigene:16181
IRAK3 GeneProduct ncbigene:73914
Il1a GeneProduct ncbigene:16175
MAPK3 GeneProduct ncbigene:26417
CAPN1 GeneProduct ncbigene:12333
IRAK4 GeneProduct ncbigene:266632
MAP3K7IP2 GeneProduct ncbigene:68652
PLCG1 GeneProduct ncbigene:18803
PRKCZ GeneProduct ncbigene:18762
MAP3K7IP1 GeneProduct ncbigene:66513
NFKB1 GeneProduct ncbigene:18033
CAPNS1 GeneProduct ncbigene:12336
NFKBIB GeneProduct ncbigene:18036
Il1r2 GeneProduct ncbigene:16178
PTPN11 GeneProduct ncbigene:19247
MAPK8 GeneProduct ncbigene:26419
CASP1 GeneProduct ncbigene:12362
SQSTM1 GeneProduct ncbigene:18412
IKBKAP GeneProduct ncbigene:230233
Il1b GeneProduct ncbigene:16176
TOLLIP GeneProduct ncbigene:54473
AKT1 GeneProduct ncbigene:11651
Myd88 GeneProduct ncbigene:17874

References