Humoral immune response to fungal and bacterial pathogens (WP3660)
Drosophila melanogaster
Pathways regulating Drosophila's humoral response to bacterial and fungal pathogens. Pathogens such as fungal B-1-3-glucans and virulence factors illicit signalling pathways through receptors on body fat cells of Drosophila Melanogaster (Protein Toll, PGRP-LC, and Domeless). The activation of receptors initiates pathways that increase transcription of antimicrobial agents and thioester proteins. This pathway is based on figure 1 from Igboin et al.
Authors
AAR&Co , Jonathan Mélius , Kristina Hanspers , and Eric WeitzActivity
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Organisms
Drosophila melanogasterCommunities
Annotations
Pathway Ontology
immune response pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PGRP-LC | GeneProduct | ensembl:FBgn0035976 | |
| upd3 | GeneProduct | ensembl:FBgn0053542 | |
| PGRP-SD | GeneProduct | ensembl:FBgn0035806 | |
| Rel | GeneProduct | ensembl:FBgn0014018 | |
| Dredd | GeneProduct | ensembl:FBgn0020381 | |
| imd | GeneProduct | ensembl:FBgn0013983 | |
| spz | GeneProduct | ensembl:FBgn0003495 | |
| psh | GeneProduct | ensembl:FBgn0030926 | |
| GNBP3 | GeneProduct | ensembl:FBgn0040321 | |
| Tl | GeneProduct | ensembl:FBgn0262473 | |
| GNBP1 | GeneProduct | ensembl:FBgn0040323 | |
| Myd88 | GeneProduct | ensembl:FBgn0033402 | |
| Tak1 | GeneProduct | ensembl:FBgn0026323 | |
| Jak | GeneProduct | ensembl:FBgn0004864 | |
| pll | GeneProduct | ensembl:FBgn0010441 | |
| PGRP-SA | GeneProduct | ensembl:FBgn0030310 | |
| ird5 | GeneProduct | ensembl:FBgn0024222 | |
| Diap2 | GeneProduct | ensembl:FBgn0015247 | |
| Fadd | GeneProduct | ensembl:FBgn0038928 | |
| tub | GeneProduct | ensembl:FBgn0003882 | |
| Tab2 | GeneProduct | ensembl:FBgn0086358 | |
| SPE | GeneProduct | ensembl:FBgn0039102 | |
| Domeless | GeneProduct | ensembl:FBgn0043903 | |
| key | GeneProduct | ensembl:FBgn0041205 | |
| Stat | GeneProduct | ensembl:FBgn0016917 | |
| Dif | GeneProduct | ensembl:FBgn0011274 | |
| cact | GeneProduct | ensembl:FBgn0000250 | |
| Diptericin | Protein | uniprot:P24492 | |
| Dorsal | Protein | uniprot:C7LA93 | Dorsal Not Specified |
| Drosomycin | Protein | uniprot:P41964 |
References
- The Drosophila melanogaster host model. Igboin CO, Griffen AL, Leys EJ. J Oral Microbiol. 2012;4:10.3402/jom.v4i0.10368. PubMed Europe PMC Scholia