Tamoxifen metabolism (WP3264)

Bos taurus

Authors

Martina Summer-Kutmon and Friederike Ehrhart

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

breast cancer pathway cancer pathway

Disease Ontology

estrogen-receptor positive breast cancer

Participants

Label Type Compact URI Comment
PAP Metabolite hmdb:HMDB0000061
tamoxifen-N-glucuronide Metabolite pubchem.compound:5460873
PAPS Metabolite pubchem.compound:10214
4-hydroxy-N-desmethyltamoxifen Metabolite pubchem.compound:3035980
trans-tamoxifen Metabolite hmdb:HMDB0014813
deamino-hydroxytamoxifen Metabolite pubchem.compound:3033897
alpha-hydroxytamoxifen Metabolite hmdb:HMDB0060585
N,N-didesmethyltamoxifen Metabolite pubchem.compound:3036172
Metabolite Metabolite chebi:25212
trans-4-hydroxytamoxifen Metabolite pubchem.compound:449459
N-desmethyltamoxifen Metabolite pubchem.compound:3032890
MGC127055 GeneProduct ensembl:ENSBTAG00000026501 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100197
CYP2A6 GeneProduct ensembl:ENSBTAG00000047815 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000255974
SULT2A1 GeneProduct ensembl:ENSBTAG00000039971 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105398
CYP2C9 GeneProduct ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138109
CYP3A5 GeneProduct ensembl:ENSBTAG00000047379 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106258
CYP2C19 GeneProduct ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165841
CYP3A4 GeneProduct ensembl:ENSBTAG00000047379 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
CYP1A2 GeneProduct ensembl:ENSBTAG00000000085 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
UGT2B7 GeneProduct ensembl:ENSBTAG00000040337 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7364
SULT1E1 GeneProduct ensembl:ENSBTAG00000011952 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109193
SULT1A1 GeneProduct ensembl:ENSBTAG00000008635 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196502
FMO1 GeneProduct ensembl:ENSBTAG00000021408 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000010932
CYP2E1 GeneProduct ensembl:ENSBTAG00000018365 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130649
FMO3 GeneProduct ensembl:ENSBTAG00000020597 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000007933
UGT1A4 GeneProduct ensembl:ENSBTAG00000048275 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54657
CYP1B1 GeneProduct ensembl:ENSBTAG00000010531 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061
CYP1A1 GeneProduct ensembl:ENSBTAG00000001021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465
CYP2C8 GeneProduct ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138115
UGT2B15 GeneProduct ensembl:ENSBTAG00000040337 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196620

References

  1. Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4. Kaku T, Ogura K, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A. Biochem Pharmacol. 2004 Jun 1;67(11):2093–102. PubMed Europe PMC Scholia
  2. Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4. Ogura K, Ishikawa Y, Kaku T, Nishiyama T, Ohnuma T, Muro K, et al. Biochem Pharmacol. 2006 Apr 28;71(9):1358–69. PubMed Europe PMC Scholia
  3. Chemoprevention of breast cancer with selective oestrogen-receptor modulators. Jordan VC. Nat Rev Cancer. 2007 Jan;7(1):46–53. PubMed Europe PMC Scholia
  4. New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer. Jordan VC. Steroids. 2007 Nov;72(13):829–42. PubMed Europe PMC Scholia
  5. Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen. Lazarus P, Blevins-Primeau AS, Zheng Y, Sun D. Ann N Y Acad Sci. 2009 Feb;1155:99–111. PubMed Europe PMC Scholia