SREBP signaling (WP3194)

Bos taurus

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

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Cited In

• Gene Expression in Embryos From Norwegian Red Bulls With High or Low Non Return Rate: An RNA-Seq Study of in vivo-Produced Single Embryos (2022).

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

sterol regulatory element-binding protein signaling pathway sterol regulatory element-binding protein signaling pathway cholesterol biosynthetic pathway fatty acid biosynthetic pathway

Disease Ontology

obsolete hypercholesterolemia

Cell Type Ontology

hepatocyte

References

1. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, et al. Cell. 1993 Oct 8;75(1):187–97. PubMed Europe PMC Scholia
2. Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. Sakai J, Nohturfft A, Goldstein JL, Brown MS. J Biol Chem. 1998 Mar 6;273(10):5785–93. PubMed Europe PMC Scholia
3. Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein. Bennett MK, Ngo TT, Athanikar JN, Rosenfeld JM, Osborne TF. J Biol Chem. 1999 May 7;274(19):13025–32. PubMed Europe PMC Scholia
4. YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes. Ericsson J, Usheva A, Edwards PA. J Biol Chem. 1999 May 14;274(20):14508–13. PubMed Europe PMC Scholia
5. Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip. Nagoshi E, Imamoto N, Sato R, Yoneda Y. Mol Biol Cell. 1999 Jul;10(7):2221–33. PubMed Europe PMC Scholia
6. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Brown MS, Goldstein JL. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11041–8. PubMed Europe PMC Scholia
7. Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease. Ye J, Davé UP, Grishin NV, Goldstein JL, Brown MS. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5123–8. PubMed Europe PMC Scholia
8. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, et al. Genes Dev. 2001 May 15;15(10):1206–16. PubMed Europe PMC Scholia
9. Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Shimano H. Prog Lipid Res. 2001 Nov;40(6):439–52. PubMed Europe PMC Scholia
10. ATF6 modulates SREBP2-mediated lipogenesis. Zeng L, Lu M, Mori K, Luo S, Lee AS, Zhu Y, et al. EMBO J. 2004 Feb 25;23(4):950–8. PubMed Europe PMC Scholia
11. Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, et al. J Clin Invest. 2004 Apr;113(8):1168–75. PubMed Europe PMC Scholia
12. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Chen G, Liang G, Ou J, Goldstein JL, Brown MS. Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11245–50. PubMed Europe PMC Scholia
13. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, et al. Cell. 2005 Jan 28;120(2):261–73. PubMed Europe PMC Scholia
14. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. Sun LP, Li L, Goldstein JL, Brown MS. J Biol Chem. 2005 Jul 15;280(28):26483–90. PubMed Europe PMC Scholia
15. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Gong Y, Lee JN, Lee PCW, Goldstein JL, Brown MS, Ye J. Cell Metab. 2006 Jan;3(1):15–24. PubMed Europe PMC Scholia
16. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, et al. Nature. 2006 Aug 10;442(7103):700–4. PubMed Europe PMC Scholia
17. Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs. Dif N, Euthine V, Gonnet E, Laville M, Vidal H, Lefai E. Biochem J. 2006 Nov 15;400(1):179–88. PubMed Europe PMC Scholia
18. Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78. Lee JN, Song B, DeBose-Boyd RA, Ye J. J Biol Chem. 2006 Dec 22;281(51):39308–15. PubMed Europe PMC Scholia
19. Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver. Yamamoto T, Shimano H, Inoue N, Nakagawa Y, Matsuzaka T, Takahashi A, et al. J Biol Chem. 2007 Apr 20;282(16):11687–95. PubMed Europe PMC Scholia
20. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Radhakrishnan A, Ikeda Y, Kwon HJ, Brown MS, Goldstein JL. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6511–8. PubMed Europe PMC Scholia
21. Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step. Lee JN, Zhang X, Feramisco JD, Gong Y, Ye J. J Biol Chem. 2008 Nov 28;283(48):33772–83. PubMed Europe PMC Scholia
22. A phosphorylation cascade controls the degradation of active SREBP1. Bengoechea-Alonso MT, Ericsson J. J Biol Chem. 2009 Feb 27;284(9):5885–95. PubMed Europe PMC Scholia
23. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. Yellaturu CR, Deng X, Cagen LM, Wilcox HG, Mansbach CM 2nd, Siddiqi SA, et al. J Biol Chem. 2009 Mar 20;284(12):7518–32. PubMed Europe PMC Scholia
24. The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage. Irisawa M, Inoue J, Ozawa N, Mori K, Sato R. J Biol Chem. 2009 Oct 16;284(42):28995–9004. PubMed Europe PMC Scholia
25. Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex. Yellaturu CR, Deng X, Park EA, Raghow R, Elam MB. J Biol Chem. 2009 Nov 13;284(46):31726–34. PubMed Europe PMC Scholia
26. AMPK and SIRT1: a long-standing partnership? Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, et al. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E751-60. PubMed Europe PMC Scholia
27. The Akt-SREBP nexus: cell signaling meets lipid metabolism. Krycer JR, Sharpe LJ, Luu W, Brown AJ. Trends Endocrinol Metab. 2010 May;21(5):268–76. PubMed Europe PMC Scholia
28. Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit. Takeuchi Y, Yahagi N, Izumida Y, Nishi M, Kubota M, Teraoka Y, et al. J Biol Chem. 2010 Apr 9;285(15):11681–91. PubMed Europe PMC Scholia
29. Sterol metabolism and SREBP activation. Sato R. Arch Biochem Biophys. 2010 Sep 15;501(2):177–81. PubMed Europe PMC Scholia
30. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, et al. Genes Dev. 2010 Jul 1;24(13):1403–17. PubMed Europe PMC Scholia
31. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, et al. Mol Cell. 2010 Jul 30;39(2):171–83. PubMed Europe PMC Scholia
32. SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. Ponugoti B, Kim DH, Xiao Z, Smith Z, Miao J, Zang M, et al. J Biol Chem. 2010 Oct 29;285(44):33959–70. PubMed Europe PMC Scholia
33. PI3K/Akt pathway mediates high glucose-induced lipogenesis and extracellular matrix accumulation in HKC cells through regulation of SREBP-1 and TGF-β1. Hao J, Liu S, Zhao S, Liu Q, Lv X, Chen H, et al. Histochem Cell Biol. 2011 Feb;135(2):173–81. PubMed Europe PMC Scholia
34. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, et al. Cell Metab. 2011 Apr 6;13(4):376–88. PubMed Europe PMC Scholia
35. The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes. Zhang Y, Lei T, Huang JF, Wang SB, Zhou LL, Yang ZQ, et al. Mol Cell Endocrinol. 2011 Aug 6;342(1–2):41–7. PubMed Europe PMC Scholia
36. Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes. Inoue J, Ito Y, Shimada S, Satoh S ich, Sasaki T, Hashidume T, et al. FEBS J. 2011 Aug;278(15):2739–50. PubMed Europe PMC Scholia
37. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, et al. Cell. 2011 Aug 5;146(3):408–20. PubMed Europe PMC Scholia
38. SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells. Uttarwar L, Gao B, Ingram AJ, Krepinsky JC. Am J Physiol Renal Physiol. 2012 Feb 1;302(3):F329-41. PubMed Europe PMC Scholia
39. SREBPs: metabolic integrators in physiology and metabolism. Jeon TI, Osborne TF. Trends Endocrinol Metab. 2012 Feb;23(2):65–72. PubMed Europe PMC Scholia
40. MicroRNAs in metabolism and metabolic disorders. Rottiers V, Näär AM. Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):239–50. PubMed Europe PMC Scholia
41. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. Zhao X, Feng D, Wang Q, Abdulla A, Xie XJ, Zhou J, et al. J Clin Invest. 2012 Jul;122(7):2417–27. PubMed Europe PMC Scholia
42. Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, et al. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16184–9. PubMed Europe PMC Scholia
43. Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle. Defour A, Dessalle K, Castro Perez A, Poyot T, Castells J, Gallot YS, et al. PLoS One. 2012;7(9):e43490. PubMed Europe PMC Scholia
44. Retinol binding protein 4 stimulates hepatic sterol regulatory element-binding protein 1 and increases lipogenesis through the peroxisome proliferator-activated receptor-γ coactivator 1β-dependent pathway. Xia M, Liu Y, Guo H, Wang D, Wang Y, Ling W. Hepatology. 2013 Aug;58(2):564–75. PubMed Europe PMC Scholia
45. A pathway approach to investigate the function and regulation of SREBPs. Daemen S, Kutmon M, Evelo CT. Genes Nutr. 2013 May;8(3):289–300. PubMed Europe PMC Scholia