IL-3 signaling pathway (WP319)

Rattus norvegicus

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Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_15

Authors

Akhilesh Pandey , Christine Chichester , and Eric Weitz

Activity

last edited

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

interleukin-3 signaling pathway

Participants

Label Type Compact URI Comment
IL3 GeneProduct ncbigene:24495
Il3ra GeneProduct ncbigene:246144
Csf2rb GeneProduct ncbigene:171081
PIK3CA GeneProduct ncbigene:170911
Pik3cd GeneProduct ncbigene:366508
Hras GeneProduct ncbigene:293621
Tec GeneProduct ncbigene:84492
Vav1 GeneProduct ncbigene:25156
Jak1 GeneProduct ncbigene:84598
Jak2 GeneProduct ncbigene:24514
Ptpn6 GeneProduct ncbigene:116689
Ptpn11 GeneProduct ncbigene:25622
Lyn GeneProduct ncbigene:81515
Syk GeneProduct ncbigene:25155
Hck GeneProduct ncbigene:25734
Fyn GeneProduct ncbigene:25150
Lck GeneProduct ncbigene:313050
Stat1 GeneProduct ncbigene:25124
Stat5a GeneProduct ncbigene:24918
Stat6 GeneProduct ncbigene:362896
Stat5b GeneProduct ncbigene:25126
Stat3 GeneProduct ncbigene:25125
Rara GeneProduct ncbigene:24705
Rxra GeneProduct ncbigene:25271
Pik3r1 GeneProduct ncbigene:25513
Pik3r2 GeneProduct ncbigene:29741
Akt1 GeneProduct ncbigene:24185
Ywhaz GeneProduct ncbigene:25578
Fes GeneProduct ncbigene:361597
Cish GeneProduct ncbigene:83681
Gnb2l1 GeneProduct ncbigene:83427
Prkcb GeneProduct ncbigene:25023
Shc1 GeneProduct ncbigene:85385
YWHAQ GeneProduct ncbigene:25577
Ywhab GeneProduct ncbigene:56011
Gab2 GeneProduct ncbigene:84477
Grb2 GeneProduct ncbigene:81504
Sos1 GeneProduct ncbigene:313845
Inpp5d GeneProduct ncbigene:54259
Gab1 GeneProduct ncbigene:361388
RAPGEF1 GeneProduct ncbigene:63881
Crkl GeneProduct ncbigene:287942
Cbl GeneProduct ncbigene:500985
Crk GeneProduct ncbigene:54245
PILRB GeneProduct ncbigene:288554
Bad GeneProduct ncbigene:64639
Bcl2l1 GeneProduct ncbigene:24888
Bcl2 GeneProduct ncbigene:24224
Bax GeneProduct ncbigene:24887
Bcl2l11 GeneProduct ncbigene:64547
Ppp2ca GeneProduct ncbigene:24672
Creb1 GeneProduct ncbigene:81646
Ptk2 GeneProduct ncbigene:25614
Pxn GeneProduct ncbigene:360820
Src GeneProduct ncbigene:83805
Socs2 GeneProduct ncbigene:84607
Socs3 GeneProduct ncbigene:89829
Dnm1 GeneProduct ncbigene:140694
Vcl GeneProduct ncbigene:305679
Raf1 GeneProduct ncbigene:24703
Map2k1 GeneProduct ncbigene:170851
Rac1 GeneProduct ncbigene:363875
Rac2 GeneProduct ncbigene:366957
Mapk8 GeneProduct ncbigene:116554
Mapk1 GeneProduct ncbigene:116590
Mapk3 GeneProduct ncbigene:50689
Gata1 GeneProduct ncbigene:25172
Gata2 GeneProduct ncbigene:25159
Prkaca GeneProduct ncbigene:25636
Pak1 GeneProduct ncbigene:29431
Prkca GeneProduct ncbigene:24680
Nfkb1 GeneProduct ncbigene:81736
Slc2a1 GeneProduct ncbigene:24778
TYK2 GeneProduct ncbigene:298706
Gsk3a GeneProduct ncbigene:50686
Gsk3b GeneProduct ncbigene:84027
Kcnip3 GeneProduct ncbigene:65199
MAPK7 GeneProduct ncbigene:114509
Foxo1 GeneProduct ncbigene:84482
Hspb1 GeneProduct ncbigene:24471
Mapk14 GeneProduct ncbigene:81649
Atf2 GeneProduct ncbigene:81647
Atf1 GeneProduct ncbigene:315305
Mras GeneProduct ncbigene:25482
Kras GeneProduct ncbigene:24525
RPS6KB2 GeneProduct ncbigene:361696
Rap1a GeneProduct ncbigene:295347
BIRC5 GeneProduct ncbigene:64041
Mapkapk2 GeneProduct ncbigene:289014
Sfpi1 GeneProduct ncbigene:366126
CDC42 GeneProduct ncbigene:64465
Bmx GeneProduct ncbigene:367786
Tnfrsf1b GeneProduct ncbigene:156767
Id1 GeneProduct ncbigene:25261
Selp GeneProduct ncbigene:25651
Fcer2 GeneProduct ncbigene:171075
Mapk9 GeneProduct ncbigene:50658
Chek1 GeneProduct ncbigene:140583
Matk GeneProduct ncbigene:60450
Mmp2 GeneProduct ncbigene:81686
Mmp9 GeneProduct ncbigene:81687

References