Cytokinin signaling (WP2944)

Arabidopsis thaliana

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Cytokinin signaling pathway starts from receiving of the ligand (cytokinin) by the cytokinin receptors (a dimer), followed by a phosphate relay by acceptor and donor domains of the receptors and then the histidine phosphotransmitters (HPs). HPs activate the type-A and type-B Arabidopsis response regulators (ARRs) to initiate the downstream events in cytokinin mediated response. Caesar et al (2011) show receptor location in the endoplasmic reticulum membrane, though all the classical models show them on plasma membrane. Paralogs from the A. thaliana genome for AHKs, AHPs, Type-A and Type-B ARRs were added as group members (not as members of complex) on the pathway diagram.

Authors

Pankaj Jaiswal , Susan Coort , Egon Willighagen , Martina Summer-Kutmon , and Finterly Hu

Activity

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Organisms

Arabidopsis thaliana

Communities

Annotations

Pathway Ontology

hormone signaling pathway

Participants

Label Type Compact URI Comment
Cytokinin Metabolite chebi:23530
His(H) Metabolite chebi:15971
Asp(D) Metabolite chebi:17053
AHK2 GeneProduct ensembl:AT5G35750 Histidine Kinase 2
AHK1 GeneProduct ensembl:AT2G17820 Histidine Kinase 1
AHK3 GeneProduct ensembl:AT1G27320 Histidine Kinase 3
AHK4 GeneProduct ensembl:AT2G01830 Histidine Kinase 4
AHK5 GeneProduct ensembl:AT5G10720 Histidine Kinase 5
AHP6 GeneProduct ensembl:AT1G80100 histidine phosphotransfer protein 6
AHP3 GeneProduct ensembl:AT5G39340 histidine phosphotransfer protein 3
AHP2 GeneProduct ensembl:AT3G29350 histidine phosphotransfer protein 2
AHP4 GeneProduct ensembl:AT3G16360 histidine phosphotransfer protein 4
AHP5 GeneProduct ensembl:AT1G03430 histidine phosphotransfer protein 5
AHP1 GeneProduct ensembl:AT3G21510 histidine phosphotransfer protein 1
AHP-Like GeneProduct ensembl:AT4G04402 histidine phosphotransfer protein like
ARR3 GeneProduct ensembl:At1g59940 Type-A Arabidopsis (Arabidopsis thaliana) response regulator 3
ARR4 GeneProduct ensembl:At1g10470 Type-A Arabidopsis (Arabidopsis thaliana) response regulator 4
ARR5 GeneProduct ensembl:At3g48100 Type-A Arabidopsis (Arabidopsis thaliana) response regulator 3
ARR6 GeneProduct ensembl:At5g62920 Type-A Arabidopsis (Arabidopsis thaliana) response regulator 6
ARR8 GeneProduct ensembl:At2g41310 Type-A Arabidopsis (Arabidopsis thaliana) response regulator 8
ARR15 GeneProduct ensembl:AT1G74890 Type-A Arabidopsis (Arabidopsis thaliana) response regulator 15
ARR16 GeneProduct ensembl:AT2G40670 Type-A Arabidopsis (Arabidopsis thaliana) response regulator 16
ARR9 GeneProduct ensembl:At3g57040 Type-A Arabidopsis (Arabidopsis thaliana) response regulator 9
ARR7 GeneProduct ensembl:AT1G19050 Type-A Arabidopsis (Arabidopsis thaliana) response regulator 7
ARR17 GeneProduct ensembl:AT3G56380 Type-A Arabidopsis (Arabidopsis thaliana) response regulator 17
ARR1 GeneProduct ensembl:At3g16857 Type-B Arabidopsis (Arabidopsis thaliana) response regulator 1
ARR2 GeneProduct ensembl:At4g16110 Type-B Arabidopsis (Arabidopsis thaliana) response regulator 2
ARR10 GeneProduct ensembl:At4g31920 Type-B Arabidopsis (Arabidopsis thaliana) response regulator 10
ARR11 GeneProduct ensembl:At1g67710 Type-B Arabidopsis (Arabidopsis thaliana) response regulator 11
ARR13 GeneProduct ensembl:At2g27070 Type-B Arabidopsis (Arabidopsis thaliana) response regulator 13
ARR18 GeneProduct ensembl:At5g58080 Type-B Arabidopsis (Arabidopsis thaliana) response regulator 18
ARR19 GeneProduct ensembl:At1g49190 Type-B Arabidopsis (Arabidopsis thaliana) response regulator 19
ARR14 GeneProduct ensembl:At2g01760 Type-B Arabidopsis (Arabidopsis thaliana) response regulator 14
ARR12 GeneProduct ensembl:At2g25180 Type-B Arabidopsis (Arabidopsis thaliana) response regulator 12
ARR20 GeneProduct ensembl:At3g62670 Type-B Arabidopsis (Arabidopsis thaliana) response regulator 20
ARR21 GeneProduct ensembl:At5g07210 Type-B Arabidopsis (Arabidopsis thaliana) response regulator 21

References

  1. A transmembrane hybrid-type histidine kinase in Arabidopsis functions as an osmosensor. Urao T, Yakubov B, Satoh R, Yamaguchi-Shinozaki K, Seki M, Hirayama T, et al. Plant Cell. 1999 Sep;11(9):1743–54. PubMed Europe PMC Scholia
  2. Plant histidine kinases: an emerging picture of two-component signal transduction in hormone and environmental responses. Urao T, Yamaguchi-Shinozaki K, Shinozaki K. Sci STKE. 2001 Nov 20;2001(109):re18. PubMed Europe PMC Scholia
  3. ATHK1 gene regulates signal transduction of osmotic stress in Arabidopsis thaliana. Hao GP, Wu ZY, Chen MS, Cao MQ, Pelletier G, Huang CL, et al. Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao. 2004 Oct;30(5):553–60. PubMed Europe PMC Scholia
  4. Genome-wide expression profiling of ARABIDOPSIS RESPONSE REGULATOR 7(ARR7) overexpression in cytokinin response. Lee DJ, Park JY, Ku SJ, Ha YM, Kim S, Kim MD, et al. Mol Genet Genomics. 2007 Feb;277(2):115–37. PubMed Europe PMC Scholia
  5. Functional analysis of AHK1/ATHK1 and cytokinin receptor histidine kinases in response to abscisic acid, drought, and salt stress in Arabidopsis. Tran LSP, Urao T, Qin F, Maruyama K, Kakimoto T, Shinozaki K, et al. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20623–8. PubMed Europe PMC Scholia
  6. Analysis of the Arabidopsis histidine kinase ATHK1 reveals a connection between vegetative osmotic stress sensing and seed maturation. Wohlbach DJ, Quirino BF, Sussman MR. Plant Cell. 2008 Apr;20(4):1101–17. PubMed Europe PMC Scholia
  7. Evidence for the localization of the Arabidopsis cytokinin receptors AHK3 and AHK4 in the endoplasmic reticulum. Caesar K, Thamm AMK, Witthöft J, Elgass K, Huppenberger P, Grefen C, et al. J Exp Bot. 2011 Nov;62(15):5571–80. PubMed Europe PMC Scholia