Mapk cascade (WP251)
Mus musculus
The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. Therefore, dysregulation, or improper functioning of these cascades, is involved in the induction and progression of diseases such as cancer, diabetes, autoimmune diseases, and developmental abnormalities.
Authors
Nathan Salomonis , Ismael Reyes , Michiel Adriaens , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric WeitzActivity
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
mitogen activated protein kinase signaling pathway mitogen activated protein kinase signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| GTP | Metabolite | cas:2564-35-4 | |
| GDP | Metabolite | cas:146-91-8 | |
| Mapk14 | GeneProduct | ensembl:ENSMUSG00000053436 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1432 |
| Jun | GeneProduct | ensembl:ENSMUSG00000052684 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3725 |
| Nras | GeneProduct | ensembl:ENSMUSG00000027852 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4893 |
| Raf1 | GeneProduct | ensembl:ENSMUSG00000000441 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5894 |
| Map2k7 | GeneProduct | ensembl:ENSMUSG00000109061 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5609 |
| Map3k3 | GeneProduct | ensembl:ENSMUSG00000020700 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4215 |
| Map3k1 | GeneProduct | ensembl:ENSMUSG00000021754 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4214 |
| Mapk3 | GeneProduct | ensembl:ENSMUSG00000063065 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5595 |
| Elk1 | GeneProduct | ensembl:ENSMUSG00000009406 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2002 |
| Map2 | GeneProduct | ensembl:ENSMUSG00000015222 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4133 |
| Map2k4 | GeneProduct | ensembl:ENSMUSG00000033352 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6416 |
| Hras | GeneProduct | ensembl:ENSMUSG00000025499 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3265 |
| Map3k12 | GeneProduct | ensembl:ENSMUSG00000023050 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7786 |
| Mapk10 | GeneProduct | ensembl:ENSMUSG00000046709 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5602 |
| Map2k2 | GeneProduct | ensembl:ENSMUSG00000035027 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5605 |
| Mbp | GeneProduct | ensembl:ENSMUSG00000041607 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4155 |
| Mapk12 | GeneProduct | ensembl:ENSMUSG00000022610 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6300 |
| Map2k6 | GeneProduct | ensembl:ENSMUSG00000020623 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5608 |
| Sipa1 | GeneProduct | ensembl:ENSMUSG00000056917 | not confirmed SwissProt ID - mu: SPA1 MOUSEHomology Mapping from Homo sapiens to Mus musculus: Original ID = L:6494 |
| Mapk1 | GeneProduct | ensembl:ENSMUSG00000063358 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5594 |
| Rasa3 | GeneProduct | ensembl:ENSMUSG00000031453 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:22821 |
| Rras | GeneProduct | ensembl:ENSMUSG00000038387 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6237 |
| Araf | GeneProduct | ensembl:ENSMUSG00000001127 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:369 |
| Kras | GeneProduct | ensembl:ENSMUSG00000030265 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3845 |
| Map3k2 | GeneProduct | ensembl:ENSMUSG00000024383 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10746 |
| Braf | GeneProduct | ensembl:ENSMUSG00000002413 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:673 |
| Map2k1 | GeneProduct | ensembl:ENSMUSG00000004936 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5604 |
| Map2k3 | GeneProduct | ensembl:ENSMUSG00000018932 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5606 |
| Plcb3 | GeneProduct | ensembl:ENSMUSG00000024960 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5331 |
References
- Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR. IET Syst Biol. 2008 Jul;2(4):173–83. PubMed Europe PMC Scholia
- The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Plotnikov A, Zehorai E, Procaccia S, Seger R. Biochim Biophys Acta. 2011 Sep;1813(9):1619–33. PubMed Europe PMC Scholia