Spinal cord injury (WP2432)
Mus musculus
This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.
Authors
Nathan Salomonis , Egon Willighagen , Deborah Micael , Chris Evelo , Linda Rieswijk , and Eric WeitzActivity
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Cited In
- Comparative Screening of the Liver Gene Expression Profiles from Type 1 and Type 2 Diabetes Rat Models (2024).
- Proteomic profiling of salivary gland after nonviral gene transfer mediated by conventional plasmids and minicircles (2014).
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Organisms
Mus musculusCommunities
Annotations
Disease Ontology
spinal cord disease post-traumatic stress disorderPathway Ontology
disease pathwayCell Type Ontology
astrocyte of the spinal cordReferences
- Role of cyclooxygenase 2 in acute spinal cord injury. Resnick DK, Graham SH, Dixon CE, Marion DW. J Neurotrauma. 1998 Dec;15(12):1005–13. PubMed Europe PMC Scholia
- Improved recovery after spinal cord trauma in ICAM-1 and P-selectin knockout mice. Farooque M, Isaksson J, Olsson Y. Neuroreport. 1999 Jan 18;10(1):131–4. PubMed Europe PMC Scholia
- Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Eng LF, Ghirnikar RS, Lee YL. Neurochem Res. 2000 Oct;25(9–10):1439–51. PubMed Europe PMC Scholia
- A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats. Tonai T, Shiba K, Taketani Y, Ohmoto Y, Murata K, Muraguchi M, et al. J Neurochem. 2001 Sep;78(5):1064–72. PubMed Europe PMC Scholia
- Gene profiling in spinal cord injury shows role of cell cycle in neuronal death. Di Giovanni S, Knoblach SM, Brandoli C, Aden SA, Hoffman EP, Faden AI. Ann Neurol. 2003 Apr;53(4):454–68. PubMed Europe PMC Scholia
- Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes. Menet V, Prieto M, Privat A, Giménez y Ribotta M. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8999–9004. PubMed Europe PMC Scholia
- Stimulation of production of glial cell line-derived neurotrophic factor and nitric oxide by lipopolysaccharide with different dose-responsiveness in cultured rat macrophages. Hashimoto M, Ito T, Fukumitsu H, Nomoto H, Furukawa Y, Furukawa S. Biomed Res. 2005 Oct;26(5):223–9. PubMed Europe PMC Scholia
- Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity. Woods AS, Kaminski R, Oz M, Wang Y, Hauser K, Goody R, et al. J Proteome Res. 2006 Apr;5(4):1017–23. PubMed Europe PMC Scholia
- Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion. Fabes J, Anderson P, Yáñez-Muñoz RJ, Thrasher A, Brennan C, Bolsover S. Eur J Neurosci. 2006 Apr;23(7):1721–30. PubMed Europe PMC Scholia
- Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model. Tian D shi, Dong Q, Pan D ji, He Y, Yu Z yuan, Xie M jie, et al. Brain Res. 2007 Jun 18;1154:206–14. PubMed Europe PMC Scholia
- Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury. Terayama R, Bando Y, Murakami K, Kato K, Kishibe M, Yoshida S. Neuroscience. 2007 Aug 10;148(1):175–87. PubMed Europe PMC Scholia
- Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons. Adjan VV, Hauser KF, Bakalkin G, Yakovleva T, Gharibyan A, Scheff SW, et al. Neuroscience. 2007 Sep 7;148(3):724–36. PubMed Europe PMC Scholia
- The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury. Chu GKT, Yu W, Fehlings MG. Neuroscience. 2007 Sep 7;148(3):668–82. PubMed Europe PMC Scholia
- Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury. Liu NK, Zhang YP, Han S, Pei J, Xu LY, Lu PH, et al. J Neuropathol Exp Neurol. 2007 Oct;66(10):932–43. PubMed Europe PMC Scholia
- Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. Brain. 2008 Apr;131(Pt 4):1087–98. PubMed Europe PMC Scholia
- Effects of long-term FK506 administration on functional and histopathological outcome after spinal cord injury in adult rat. Saganová K, Orendácová J, Sulla I Jr, Filipcík P, Cízková D, Vanický I. Cell Mol Neurobiol. 2009 Sep;29(6–7):1045–51. PubMed Europe PMC Scholia
- Pathogenic antibodies are active participants in spinal cord injury. Dekaban GA, Thawer S. J Clin Invest. 2009 Oct;119(10):2881–4. PubMed Europe PMC Scholia
- Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion. Pineau I, Sun L, Bastien D, Lacroix S. Brain Behav Immun. 2010 May;24(4):540–53. PubMed Europe PMC Scholia
- Eph receptor tyrosine kinases regulate astrocyte cytoskeletal rearrangement and focal adhesion formation. Puschmann TB, Turnley AM. J Neurochem. 2010 May;113(4):881–94. PubMed Europe PMC Scholia
- The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury. Saiwai H, Ohkawa Y, Yamada H, Kumamaru H, Harada A, Okano H, et al. Am J Pathol. 2010 May;176(5):2352–66. PubMed Europe PMC Scholia
- CD47 knockout mice exhibit improved recovery from spinal cord injury. Myers SA, DeVries WH, Andres KR, Gruenthal MJ, Benton RL, Hoying JB, et al. Neurobiol Dis. 2011 Apr;42(1):21–34. PubMed Europe PMC Scholia
- Current and future therapeutic strategies for functional repair of spinal cord injury. Tohda C, Kuboyama T. Pharmacol Ther. 2011 Oct;132(1):57–71. PubMed Europe PMC Scholia
- Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. J Neurotrauma. 2011 Sep;28(9):1893–907. PubMed Europe PMC Scholia
- Repertoire of microglial and macrophage responses after spinal cord injury. David S, Kroner A. Nat Rev Neurosci. 2011 Jun 15;12(7):388–99. PubMed Europe PMC Scholia
- Phospholipase A2 superfamily members play divergent roles after spinal cord injury. López-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayianni E, Antonopoulou G, et al. FASEB J. 2011 Dec;25(12):4240–52. PubMed Europe PMC Scholia
- Activated microglia inhibit axonal growth through RGMa. Kitayama M, Ueno M, Itakura T, Yamashita T. PLoS One. 2011;6(9):e25234. PubMed Europe PMC Scholia
- Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. Huang C, Han X, Li X, Lam E, Peng W, Lou N, et al. J Neurosci. 2012 Mar 7;32(10):3333–8. PubMed Europe PMC Scholia
- PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition. Shim SO, Cafferty WBJ, Schmidt EC, Kim BG, Fujisawa H, Strittmatter SM. Mol Cell Neurosci. 2012 Jun;50(2):193–200. PubMed Europe PMC Scholia
- Immunosuppressant FK506: focusing on neuroprotective effects following brain and spinal cord injury. Saganová K, Gálik J, Blaško J, Korimová A, Račeková E, Vanický I. Life Sci. 2012 Aug 21;91(3–4):77–82. PubMed Europe PMC Scholia
- p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury. Floriddia EM, Rathore KI, Tedeschi A, Quadrato G, Wuttke A, Lueckmann JM, et al. J Neurosci. 2012 Oct 3;32(40):13956–70. PubMed Europe PMC Scholia
- Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord. Im YB, Jee MK, Choi JI, Cho HT, Kwon OH, Kang SK. Cell Death Dis. 2012 Nov 15;3(11):e426. PubMed Europe PMC Scholia